Effects of Inbreeding on Morbidity: A Study Among Three South Indian Communities

Reddy, T.P.K.; Reddy, P. Govinda

doi:10.1080/09709274.1996.11907186

Cited by 5 publications

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“…In recent past, India experienced the large‐scale socioeconomic transformation. However, the existing research on consanguinity is already quite old by now; therefore, the results of these studies is not generalizable any more (Dronamraju and Meera Khan, 1963; Centerwall, 1965; Centerwall and Centerwall, 1966; John and Jayabal, 1971; Beck, 1972; Rao and Inbaraj, 1977, 1979, 1980; Rao et al , 1988; Rao, 1991; Bittles et al , 1985, 1987, 1992; Chakraborty and Chakravarti, 1977; Devi et al , 1981, 1987; Reddy, 1985; Kulkarni and Kurian, 1990; George et al , 1992; Babu et al , 1994; Sureender et al , 1998).…”

Section: Introductionmentioning

confidence: 98%

“…The latter category comprises of studies which focus at local or regional level evidences based on case studies, which examined the factors affecting the consanguineous marriages and their effects on pregnancy outcomes, are limited in scope and hence could not be considered representative of the general population (Nath et al, 2004). A large proportion of the existing research based on local and national surveys is not relevant to current conditions because India experienced a large scale socioeconomic transformation in the recent past (Dronamraju and Khan, 1963;Centerwall, 1965;Centerwall & Centrewall, 1966;Jhon & Jayabal 1971;Beck, 1972;Rao & Inbaraj, 1977, 1979, 1980Rao et al 19881;Rao, 1991;Bittles et al, 1985Bittles et al, , 1987Bittles et al, , 1992Chakraborty & Chakravarti 1977;Devi et al 1981Devi et al , 1987Reddy, 1985;Kulkarni & Kurian, 1990;George et al 1992;Babu et al, 1994;Sureender et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Consanguineous marriages and their effects on pregnancy outcomes in India

Kuntla

Goli

Sekher

et al. 2013

International Journal of Sociology and Social Policy

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Purpose-The purpose of this study is to investigate the association between the marriage among the blood relatives and adverse pregnancy outcomes. Data and Methods-This study uses data from India Human Development Survey (IHDS, 2005). The methods of analyses include bivariate, trivariate and Cox proportional hazard regression models. Results-The results reveal that the occurrence of consanguineous marriages is more predominant in the states of southern India and among the socioeconomically disadvantageous groups. Moreover, the women in consanguineous union are more likely to have adverse pregnancy outcomes including stillbirths (RR=1.59, p-value < 0.01), abortions (RR = 3.03, p-value < 0.01), miscarriages (RR=1.94, p-value < 0.01) and spontaneous miscarriages (RR=1.70, p-value < 0.01) than non-consanguineous marriage. The consanguineous marriages continue to be a critical predictor of adverse pregnancy outcomes in India. Implications-In order to avoid wastage of pregnancy and related reproductive health problems in India, it is imperative to initiate awareness creation measures regarding the adverse effect of consanguineous marriages, particularly in those regions where it is still dominantly prevalent. Originality-For the first time in India, this study comprehensively examined the occurrence of consanguineous marriages and their association with adverse pregnancy outcomes by using advanced statistical analyses and national-wide sample survey data.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Consanguineous marriages and their effects on pregnancy outcomes in India

Kuntla

Goli

Sekher

et al. 2013

International Journal of Sociology and Social Policy

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“…Consanguinity is an important factor in the appearance of recessively transmitted hereditary diseases and congenital defects [Vogel and Motulsky, 19861. It has been shown to contribute to other reproductive hazards such as sterility, infant mortality, child deaths, as well as spontaneous abortion and stillbirths [Rao et al, 1972;Scott-Emuakpor, 1974;Tanaka, 1977;Chakraborty and Chakravarti, 1977;Reddy, 1985;A1 Awadi et al, 1985;Khoury et al, 1987a;Guz et al, 19891. The risk for birth defects in the offspring of first cousin matings has been estimated to increase to 5-8% compared to 2-38 in nonconsanguineous marriages [Schull, 1958;F'raser and Biddle, 1976;Naderi, 1979;Magnus et al, 19851. In contrast to some populations such as those in Pakistan [Honeyman et al, 19871, South India [Reddy, 1985;Radha et al, 19871, some parts of Turkey [see Guz et al, 19891, Jordan [Khoury and Massad, 19921, and Israeli Arab villages [Jaber et al, 19921, a general decline in the frequency of consanguineous marriages was observed in this century [Vogel and Motulsky, 19861.…”

Section: Introductionmentioning

confidence: 99%

Parental consanguinity as a cause of increased incidence of birth defects in a study of 131, 760 consecutive birthsxs

et al. 1994

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The risk for birth defects in the offspring of first cousin parents is substantially higher than in the offspring of non-consanguineous parents. As a general decline in the frequency of consanguineous marriages was observed in this century, one wonders whether consanguinity is still a factor in the appearance of birth defects in developed countries. Based on our registry of congenital anomalies, we think that the answer to this question is "yes." In the population studied in Northeastern France, consanguineous matings were known in 1.08% of the cases with congenital anomalies, vs. 0.28% in controls ( P < 0.001). The frequency of lbe malformations recorded paralleled the degree of consanguinity: out of 38 malformed children, 24 were seen in first cousin matings (10.5 times more frequent than in offspring of nonconsanguineous couples), 8 in second cousin marriages, and 6 in more distantly consanguineous matings.Consanguineous mothers were more often pregnant than nonconsanguineous mothers ( P < 0.01) and they had more stillbirths than nonconsanguineous mothers. These results must be taken into account when counseling consanguineous couples. Q 1994 Wiley-Liss, Inc.

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“…Many papers can be found in the bibliography, in which diverse factors regulating infant risk of death are analyzed, such as sex (Harpending and Pennington, 1991), parental consanguinity (Reddy and Rao, 1978;Reddy, 1985), twining (Bulmer, 1970), parity (Swenson et al, 1993), birth interval (Brittain, 1992;Hobcraft et al, 1985), or maternal age (Reddy, 1985;Swenson, 1981). The ecological characteristics of a geographical area can also influence the infant mortality pattern.…”

mentioning

confidence: 99%

Child age influence on the seasonal death risk during the first year of life (Spain, 1975–1989)

Luna

Alonso-Ferreira

Fuster

et al. 2008

American J Hum Biol

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Infant mortality rate reflects a population's health status, which depends on several factors, such as diseases, environment, child development, and other population characteristics that can show seasonal change throughout the year. This article deals with the relevance of child age on the probability of death in the different seasons throughout the first year of life, taking into account the illnesses causing death. The study was carried out using a file from the Spanish National Institute of Statistics. To eliminate bias related to health improvement, only the 49,761 urban deaths corresponding to capital of provinces, taking place between 1975 and 1989, were considered. The variables analyzed were: the month in which death took place, disease causing death, and the child age at death. Since many causes of death are very infrequent, the analysis was limited to a selection of the most common 45,155 death cases. The causes of death analyzed were: digestive, nervous and sensory, circulatory, and respiratory diseases, delivery difficulties, congenital anomalies, and signs and syndromes (WHO, ICD-9). The infant mortality rates are associated with the child age at death. Moreover, a general ontogenetic change of the death risk can be observed, with some particularities depending on the disease analyzed. In general, regarding all infant deaths, the obtained results suggest a higher risk of dying in winter for children surviving the first month of life, whereas a summer pattern, with a maximum mortality in June, July, and August, appeared when newborns younger than 1 week were considered.

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Effects of Inbreeding on Morbidity: A Study Among Three South Indian Communities

Cited by 5 publications

References 0 publications

Consanguineous marriages and their effects on pregnancy outcomes in India

Consanguineous marriages and their effects on pregnancy outcomes in India

Parental consanguinity as a cause of increased incidence of birth defects in a study of 131, 760 consecutive birthsxs

Child age influence on the seasonal death risk during the first year of life (Spain, 1975–1989)

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