Effects of in vitro heat shock on immune cells in diet-induced obese mice

Hypertension and obesity are usually associated with systemic and tissular inflammation. The progressive affection of target-organs involves multiple mediators of inflammation, most of them redundant, which make anti-inflammatory strategies ineffective. Melatonin reduces blood pressure, body weight, and inflammation. The mechanisms of action of this ancient molecule of protection involve multiple levels of action, from subcellular to intercellular. Mitochondria is a key inflammatory element in vascular and adipose tissue and a potential pharmacological target. Melatonin protects against mitochondrial dysfunction. Melatonin reduces blood pressure and adipose tissue dysfunction by multiple anti-inflammatory/antioxidant actions and provides potent protection against mitochondria-mediated injury in hypertension and obesity. This inexpensive and multitarget molecule has great therapeutic potential against both epidemic diseases.

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Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension

Prado

Ferder

Manucha

et al. 2018

Curr Hypertens Rep

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Effects of in vitro heat shock on immune cells in diet-induced obese mice

Cited by 1 publication

References 39 publications

Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension

Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension

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