Effects of in-vitro cultured calculus bovis on learning and memory impairments of hyperlipemia vascular dementia rats

Zhang, Xiaoming; Ren, Xuecong; Lou, Ye-Liang; Chen, Meng-Jing; Li, Guanze; Xueyuan, Gong; Huang, Zhen

doi:10.1016/j.jep.2016.09.014

Cited by 16 publications

(13 citation statements)

References 6 publications

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“…Moreover, a combination of TM and western medicine can greatly improve clinical efficacy and is accepted by various countries, such as China, Japan, India, and South Korea [ 5 , 27 ]. Previous pharmacological studies have shown that CBS was beneficial in treating neurological diseases, including hyperlipemia vascular dementia [ 43 ]. Recently, a clinical study demonstrated that a combination of CBS and haloperidol significantly reduced the dosage of haloperidol in treating schizophrenia compared with haloperidol treatment alone.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the synergistic effects of haloperidol combined with <i>Calculus Bovis Sativus</i> in treating MK-801-induced schizophrenia in rats

Lou

Zhang

et al. 2018

Exp. Anim.

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Clinical studies that focused on treating schizophrenia showed that Calculus Bovis Sativus (CBS), a substitute of Calculus Bovis, when used in combination with haloperidol could significantly lower the dosage of haloperidol compared with treatment with haloperidol alone, whereas efficacy was maintained. The aim of this study was to investigate the synergetic anti-schizophrenia effects in rats using CBS in combination with haloperidol. An open field test was conducted to verify the pharmacodynamic effects of a combination treatment of CBS and haloperidol on MK-801-induced schizophrenic rats. Rat plasma concentrations of intragastric haloperidol and intravenous haloperidol were determined after oral administration of a single dose or 1-week of pretreatment with CBS (50 mg/kg). The pharmacodynamic data showed a significant decrease in locomotor activity and an increase in the percentage of the central distance when haloperidol was concomitantly administered with CBS compared with haloperidol administration alone. The AUC0-∞ and Cmax of haloperidol in the orally coadministered groups were significantly higher compared with the oral treatment with haloperidol alone. In conclusion, oral coadministration of CBS with haloperidol resulted in a synergistic effect in rats. The enhanced oral bioavailability of haloperidol when combined with CBS might be attributed to the interaction between them.

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Section: Introductionmentioning

confidence: 99%

Investigation of the synergistic effects of haloperidol combined with <i>Calculus Bovis Sativus</i> in treating MK-801-induced schizophrenia in rats

Lou

Zhang

et al. 2018

Exp. Anim.

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“…The anti-oxidative activity of CBS has been previously confirmed in other diseases, including intrahepatic cholestasis and hyperlipemia vascular dementia. 27 , 28 In addition, the oxidation-resistance effect may be closely related to its material basis. Bilirubin (over 35.0%) or bile acids, which are the main pharmaceutical ingredients of CBS, have been found to have the ability of scavenging free radicals.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes

He¹,

Yan²,

Zhang³

et al. 2017

DDDT

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Calculus bovis (CB, niu-huang) is a high-class therapeutic drug that is often used in traditional Chinese medicine. CB helps to eliminate heat and toxic components, and prevents the accumulation of phlegm and blood stasis in the liver. In Asian countries, CB Sativus (CBS), an ideal substitute for natural CB, is presently extensively used for long-term treatment of chronic liver diseases. The present study aimed to evaluate the effects and potential mechanism(s) of action of CBS on mice with fructose-induced nonalcoholic fatty liver disease (NAFLD). The NAFLD model was established in C57BL/6 mice by exclusively feeding fluids containing 30% fructose for 8 consecutive weeks. After these 8 weeks, mice were given CBS (50 mg/kg/day or 100 mg/kg/day) for 2 consecutive weeks. Treatment with CBS reversed the fructose-induced impaired glucose tolerance. Compared with the model group, in which mice received 8 weeks of high-fructose diet and 2 weeks of 0.5% sodium carboxymethyl cellulose, CBS treatment significantly decreased the levels of fasting serum glucose, fasting insulin, triglyceride, and total cholesterol, and increased levels of high-density lipoprotein-cholesterol. CBS treatment also significantly decreased the levels of triglyceride, total cholesterol, and free fatty acid in the liver. The activity of superoxide dismutase in the liver was increased after treatment with CBS, however, levels of malondialdehyde and reactive oxygen species decreased. Histopathological examination showed that liver steatosis and injury were significantly reduced in CBS-treated mice. The expression of fatty acid synthase, nuclear factor kappa-light-chain-enhancer of activated B cells, Cysteinyl aspartate-specific proteinase-3, and synonyms B-cell leukemia/lymphoma-2 gene-associated X protein were downregulated after treatment with CBS, whereas the expression of nuclear factor erythroid-2-related factor 2 was upregulated. In conclusion, CBS treatment exerted therapeutic effects in the liver of mice with NAFLD, which may be associated with amelioration of metabolic disorders, enhanced antioxidant effects, and alleviation of apoptosis.

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“…Natural drugs with active ingredients also hold great promise in the treatment of VaD. Administrations of the Sailuotong (SLT) formula [42], Jiji decoction [43], alphanaphthoflavone (ANF) [44], and in-vitro cultured calculus bovis (ICCB) [45], inhibit oxidative stress by increasing SOD and GSH activity in the hippocampus of VaD rats, markedly rescueing the cognitive deficits. SLT, a threeherb formula composed of Panax ginseng, Ginkgo biloba, and Crocus sativus, has been used to treat VaD [46].…”

Section: Promotion Of Free Radical Scavengingmentioning

confidence: 99%

“…Immunohistochemical results demonstrate that Bax expression is remarkably increased, and Bcl-2 expression is decreased, in VaD rats, resulting in a high Bax/Bcl-2 ratio [45,126]. The administration of ICCB [45], osthole [128], PNC [61], Panax ginseng [132], total harmaline alkaloid extract [133], and SLT [42] reduces the Bax/Bcl-2 ratio and exerts anti-apoptotic properties in the brain of VaD rats, alleviating the cognitive deficits. Based on the above research, the Chinese medicinal formula, SLT, can improve VaD symptoms via multiple mechanisms, including oxidative stress, neuroinflammation, and neuronal apoptosis.…”

Section: Suppression Of Bax/bcl-2 Ratiomentioning

confidence: 99%

Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective

Kuang¹,

Zhou²,

Zhu³

et al. 2021

Aging and disease

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Effects of in-vitro cultured calculus bovis on learning and memory impairments of hyperlipemia vascular dementia rats

Cited by 16 publications

References 6 publications

Investigation of the synergistic effects of haloperidol combined with <i>Calculus Bovis Sativus</i> in treating MK-801-induced schizophrenia in rats

Investigation of the synergistic effects of haloperidol combined with <i>Calculus Bovis Sativus</i> in treating MK-801-induced schizophrenia in rats

Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes

Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective

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