Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size

Miyashita, Chihiro; Sasaki, Seiko; Ikeno, Taketo; Araki, Atsuko; Ito, Sachiko; Kajiwara, Jumboku; Todaka, Takashi; Hachiya, Noriyuki; Yasutake, Akira; Murata, Katsuyuki; Nakajima, Tamie; Kishi, Reiko

doi:10.1016/j.scitotenv.2015.06.108

Cited by 29 publications

(15 citation statements)

References 72 publications

(123 reference statements)

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“…The results are shown in Table 7 . We observed that PCDD/PCDFs and PFASs were associated with decreased birth weight [ 33 , 34 ]; however, DEHP, PCBs, and total Hg were not associated with birth weight [ 35 , 36 ]. Our investigation not only was on conventional birth weight but also included cord adipokines considered to be biomarkers of metabolic function [ 35 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

Kishi

Araki

Minatoya

et al. 2017

Environ Health Prev Med

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The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking. The purpose of this report is to update the progress of the Hokkaido Study, to summarize the recent results, and to suggest future directions. In particular, this report provides the basic characteristics of the cohort populations, discusses the population remaining in the cohorts and those who were lost to follow-up at birth, and introduces the newly added follow-up studies and case-cohort study design. In the Sapporo cohort of 514 enrolled pregnant women, various specimens, including maternal and cord blood, maternal hair, and breast milk, were collected for the assessment of exposures to dioxins, polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances, phthalates, bisphenol A, and methylmercury. As follow-ups, face-to-face neurobehavioral developmental tests were conducted at several different ages. In the Hokkaido cohort of 20,926 enrolled pregnant women, the prevalence of complicated pregnancies and birth outcomes, such as miscarriage, stillbirth, low birth weight, preterm birth, and small for gestational age were examined. The levels of exposure to environmental chemicals were relatively low in these study populations compared to those reported previously. We also studied environmental chemical exposure in association with health outcomes, including birth size, neonatal hormone levels, neurobehavioral development, asthma, allergies, and infectious diseases. In addition, genetic and epigenetic analyses were conducted. The results of this study demonstrate the effects of environmental chemical exposures on genetically susceptible populations and on DNA methylation. Further study and continuous follow-up are necessary to elucidate the combined effects of chemical exposure on health outcomes.

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Section: Resultsmentioning

confidence: 99%

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

Kishi

Araki

Minatoya

et al. 2017

Environ Health Prev Med

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“…Although n -3 PUFAs are essential for normal brain development, we could not determine the levels because of the limited amount of cord blood available. Instead of n -3 PUFAs, we used fish/seafood intake in the data analysis, whereas it is thought to indicate the exposure levels of both beneficial nutrients and toxic substances such as methylmercury and dioxin-like PCBs [ 27 , 49 ]. Other persistent organic pollutants such as dioxin-like PCBs, polychlorinated dibenzo-p-dioxines, and polychlorinated dibenzofurans, were not analyzed in this study but a significant correlation between dioxin-like PCBs and ΣPCB ( r = 0.91) was observed in 49 samples of our participants [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this case, use of concurrent exposure model will be desirable for considering the interactive effect of potential substances other than the concerned one, even though the exposure levels were not so high. In fact, essential nutrients such as n -3 polyunsaturated fatty acids (PUFAs) masked the effects of methylmercury [ 26 , 27 ]. Also, two previous studies demonstrated the association between maternal PCB concentrations and low birth weight only in male newborns [ 28 , 29 ], hypothesizing that male fetuses may be more vulnerable to such toxicants than female ones.…”

Section: Introductionmentioning

confidence: 99%

Effects of intrauterine exposures to polychlorinated biphenyls, methylmercury, and lead on birth weight in Japanese male and female newborns

Tatsuta

Kurokawa

Nakai

et al. 2017

Environ Health Prev Med

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BackgroundThe effects of prenatal exposures to polychlorinated biphenyls (PCBs), methylmercury, and lead on birth weight remain disputable. The aim of this study was to investigate whether these chemicals affect birth weight of Japanese newborns, with special emphasis on determining whether these effects differ between males and females.MethodsThe subjects from Tohoku Study of Child Development, which was designed to examine the developmental effects of prenatal exposures to such hazardous chemicals, were 489 mother-newborn pairs with complete data including smoking habit during pregnancy.ResultsThe mean birth weight of all newborns was 3083 (range, 2412–4240) g. The median values of biomarkers in cord blood were 46.0 (5th and 95th percentiles, 18.6–113.8) ng/g–lipid for total PCBs, 10.1 (4.3–22.4) ng/g for total mercury (THg), and 1.0 (0.6-1.7) μg/dL for lead. The birth weight was significantly heavier in the 252 male newborns than in the 237 female ones. A negative association between total PCBs and birth weight was observed in both male and female newborns, even after adjusting for possible confounders. However, a negative association of THg with birth weight was found only in the male newborns. There was no significant relationship between lead and birth weight in both groups.ConclusionBirth weight appears to be affected by prenatal PCB exposure in Japanese male and female newborns, and the effect of methylmercury exposure on male fetal growth may be stronger than that for females. This implication is that the effects on fetal growth should be assessed in males and females separately.

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“…Furthermore, maternal fish intake is associated with DLCs and mercury exposure during pregnancy (Miyashita et al, 2015a(Miyashita et al, , 2015bGrandjean et al, 1997). In our cohort study, the mercury level of mothers' hair (median 1.33 ppm [minimum-maximum 0.46-7.55 ppm) and the fatty acid level of maternal blood were examined (Kishi et al, 2013(Kishi et al, , 2015Miyashita et al, 2015a).…”

Section: Other Factors Associated With Dlc Exposurementioning

confidence: 99%

“…We have also examined the association between in utero exposure to PCBs, MeHg, and polyunsaturated fatty acids and the birth size, and consequently observed positive association with MeHg. The beneficial effect of essential nutrition may mask the adverse effects of MeHg on the birth size (Miyashita et al, 2015b). Other potential factors increasing the AS scores are maternal seafood intake, which might affect the neurodevelopment (Suzuki.et al, 2010).…”

Section: Other Factors Associated With Dlc Exposurementioning

confidence: 99%

Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months

Ikeno

Miyashita

Nakajima

et al. 2018

Science of The Total Environment

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Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size

Cited by 29 publications

References 72 publications

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

The Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017

Effects of intrauterine exposures to polychlorinated biphenyls, methylmercury, and lead on birth weight in Japanese male and female newborns

Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months

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