Effects of in Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure on Responsiveness of the Male Rat Reproductive System to Testosterone Stimulation in Adulthood

Bjerke, Donald L.; Sommer, Rebecca J.; Moore, Robert W.; Peterson, Richard E.

doi:10.1006/taap.1994.1159

Cited by 69 publications

(28 citation statements)

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“…Another series of studies reported different effects for in utero versus lactational exposure (201), a decrease in the responsiveness of ventral prostate after in utero and lactational exposure (202), and partial demasculinization and feminization of male sex behavior with in utero and lactational exposure (203). Gray et al (204) showed that prenatal exposure to TCDD permanently reduced sperm number and sex accessory weights but did not alter testosterone levels.…”

Section: Reduced Male Fertilitymentioning

confidence: 99%

Understanding the human health effects of chemical mixtures.

Carpenter

Arcaro

Spink

2002

Environ Health Perspect

323

198

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Most research on the effects of chemicals on biologic systems is conducted on one chemical at a time. However, in the real world people are exposed to mixtures, not single chemicals. Although various substances may have totally independent actions, in many cases two substances may act at the same site in ways that can be either additive or nonadditive. Many even more complex interactions may occur if two chemicals act at different but related targets. In the extreme case there may be synergistic effects, in which case the effects of two substances together are greater than the sum of either effect alone. In reality, most persons are exposed to many chemicals, not just one or two, and therefore the effects of a chemical mixture are extremely complex and may differ for each mixture depending on the chemical composition. This complexity is a major reason why mixtures have not been well studied. In this review we attempt to illustrate some of the principles and approaches that can be used to study effects of mixtures. By the nature of the state of the science, this discussion is more a presentation of what we do not know than of what we do know about mixtures. We approach the study of mixtures at three levels, using specific examples. First, we discuss several human diseases in relation to a variety of environmental agents believed to influence the development and progression of the disease. We present results of selected cellular and animal studies in which simple mixtures have been investigated. Finally, we discuss some of the effects of mixtures at a molecular level.

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Section: Reduced Male Fertilitymentioning

confidence: 99%

Understanding the human health effects of chemical mixtures.

Carpenter

Arcaro

Spink

2002

Environ Health Perspect

323

198

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“…3) In female rats, TCDD is known to result in endometriosis, 4) fewer pregnancies, 2) and teratogenicity 5) of offspring exposed via the maternal body. A decrease in plasma testosterone has been reported in many studies, 1,6) but no change 2,7,8) and even an increase 9) has been mentioned in some reports. The effects and outcomes vary widely according to TCDD dose, development status of the animals, exposure process, and animal strain.…”

Section: Introductionmentioning

confidence: 94%

Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Testosterone Production in Isolated Murine Testicular Cells.

Uchida

Yoshida

Inui

et al. 2002

JOURNAL OF HEALTH SCIENCE

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)is an endocrine disruptor that is known to have widespread effects on the reproductive system. We examined the effects of TCDD on testosterone production of primary cultured murine testicular cells. The cells, derived from the testes of ICR mice at age 65 days, were exposed to 10 -2 -10 4 pM TCDD for 3, 24, or 48 hr and treated with human chorionic gonadotropin for 6 hr to induce production of testosterone. At these concentrations of TCDD, the viability of testicular cells was not affected. No significant time-or TCDD concentration-dependent effects were observed on the secretion of testosterone. The data suggest that TCDD does not have a direct influence on testosterone production in the ICR mouse.

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“…Most (24), and growth retardation in primates and rats (19,25). In the endocrine system, the effects included reduced T4 levels in the prefrontal cortex of rats (25), reduced testosterone levels in rats (22,23), and altered dopamine levels in the forebrain of primates and rats (14,26,27). Neurobehavioral effects included spatial learning/memory deficits in primates and rats (27)(28)(29)(30).…”

Section: Biomarkers Of Exposurementioning

confidence: 99%

Workshop on Perinatal Exposure to Dioxin-Like Compounds. VI. Role of Biomarkers

Hooper¹,

Clark²

1995

Environmental Health Perspectives

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Studies of perinatal exposures to dioxin-like compounds (DLCs), coplanar polycyclic halogenated aromatics whose prototype is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), have employed a variety of outcome measures to investigate effects on the reproductive/developmental, endocrine, immune, and neurobehavioral systems. The effects include infertility, growth retardation, fetal loss, changed sexual differentiation, reduced cognitive/motor function, dermatologic and other ectodermal effects, and decreased immune response. Significant biomarkers have included sperm count; CD4/CD8 ratio; and levels of testosterone, T4, and dopamine. Using specific dioxin or PCB congeners, these and other markers were used to investigate the mechanisms of the observed effects. The DLCs, which include some PCB congeners, are characterized by high-affinity binding to the Ah receptor; most biological effects are thought to be mediated by the ligand-Ah receptor complex. Other PCB congeners have low affinity for the Ah receptor, and operate by non-Ah receptor mechanisms. The biologic activity of a PCB mixture is the sum of the agonist and antagonist activities of the different constituents in the mixture. Animal studies with specific PCB congeners can help to clarify these activities. With similar approaches, biologic markers of effect can be developed and applied in epidemiologic studies to monitor for, and predict, adverse effects in humans. -Environ Health Perspect 103(Suppl 2): 161-167 (1995)

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Effects of in Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure on Responsiveness of the Male Rat Reproductive System to Testosterone Stimulation in Adulthood

Cited by 69 publications

References 0 publications

Understanding the human health effects of chemical mixtures.

Understanding the human health effects of chemical mixtures.

Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Testosterone Production in Isolated Murine Testicular Cells.

Workshop on Perinatal Exposure to Dioxin-Like Compounds. VI. Role of Biomarkers

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