Effects of implant surface mechanical instrumentation methods on peri-implantitis: An in vitro study using a circumferential bone defect model

Munakata, Motohiro; Suzuki, Akihiro; Yamaguchi, Kikue; Kataoka, Yasufumi; Sanda, Minoru

doi:10.1016/j.jds.2021.08.018

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Clauser et al [127] conducted a systematic evaluation and meta-analysis, which found a significant association between bone enlargement procedures and early implant failure. Munakata et al [128] summarized the factors related to early implant failure and concluded that various surgical choices of graft materials and appropriate surgical techniques can help prevent it. Late failure is mainly caused by bacterial infection.…”

Section: Postoperative Evaluation and Patient Expectations Of Implantsmentioning

confidence: 99%

Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications

Gao,

Pan,

Gao

et al. 2024

Coatings

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Additive manufacturing, commonly known as 3D printing technology, has become a prominent topic of research globally in recent years and is playing an increasingly important role in various industries. Particularly within the healthcare sector, the use of 3D printing technology is gaining prominence, with a special focus on the manufacturing and application of dental implants. As research in this field progresses, the preparation methods, material selection, and technological innovations for dental implants are evolving, promising a future where the manufacturing process of dental implants becomes even more refined and efficient. Through thorough research in materials science, it is possible to develop dental implant materials that have better biocompatibility with the human body and improved mechanical properties. Additionally, advancements in surface modification technology can further enhance the strength and stability of the bond between dental implants and bone tissue. These advancements not only expand treatment options for patients but also greatly improve the long-term success rate of dental implants. In the field of dental implants, the success of the implant depends on the interactions between the materials used, the cells involved, and the bone tissue. Therefore, there is an urgent need to explore the molecular mechanisms of such interactions in depth. In this study, we provide a comprehensive review of the application of 3D printing technology in the fabrication of dental implants. This includes an examination of the process methods, surface coating technology, and a comparison of the shapes and structures of different dental implants, along with their advantages and disadvantages. Furthermore, this paper analyzes the intrinsic mechanisms of successful dental implant placement in clinical practice, and it highlights the latest progress in the clinical application of 3D-printed dental implants. Undeniably, the use of 3D-printed dental implants not only offers patients more precise and personalized treatment plans but also brings revolutionary changes to the development of the medical industry.

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Section: Postoperative Evaluation and Patient Expectations Of Implantsmentioning

confidence: 99%

Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications

Gao,

Pan,

Gao

et al. 2024

Coatings

View full text Add to dashboard Cite

show abstract

“…The mainstream clinical treatments rely on mechanical debridement and antibiotic therapy (Mahato et al 2016). Although the above methods have achieved positive therapeutic effects, mechanical debridement may cause scratches on the implant surface (Munakata et al 2022), and abuse of antibiotics may induce bacterial drug resistance (Wang et al 2020). Therefore, construction of an antibacterial dental implant surface is of crucial significance in preventing implant infection (Chen, Wang, et al 2021).…”

Section: Introductionmentioning

confidence: 99%

UiO-66/AgNPs Coating for Dental Implants in Preventing Bacterial Infections

Yu,

et al. 2024

J Dent Res

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Titanium (Ti)–based biomaterials lack inherent antimicrobial activities, and the dental plaque formed on the implant surface is one of the main risk factors for implant infections. Construction of an antibacterial surface can effectively prevent implant infections and enhance implant success. Silver nanoparticles (AgNPs) exhibit broad antibacterial activity and a low tendency to induce drug resistance, but AgNPs easily self-aggregate in the aqueous environment, which significantly impairs their antibacterial activity. In this study, UiO-66/AgNP (U/A) nanocomposite was prepared, where zirconium metal–organic frameworks (UiO-66) were employed as the confinement matrix to control the particle size and prevent aggregation of AgNPs. The bactericidal activity of U/A against methicillin-resistant Staphylococcus aureus and Escherichia coli increased nearly 75.51 and 484.50 times compared with individually synthesized Ag. The antibacterial mechanism can be attributed to the enhanced membrane rupture caused by the ultrafine AgNPs on UiO-66, leading to protein leakage and generation of intracellular reactive oxygen species. Then, U/A was loaded onto Ti substrates (Ti-U/A) by using self-assembly deposition methods to construct an antibacterial surface coating. Ti-U/A exhibited excellent antibacterial activities and desired biocompatibility both in vitro and in vivo. The U/A nanocomposite coating technique is thus expected to be used as a promising surface modification strategy for Ti-based dental implants for preventing dental implant infections.

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“…Nonsurgical methods for peri-implantitis mainly involve mechanical debridement (scaling and sandblasting) and adjunctive therapy (chlorhexidine) with the aim to remove dental plaque; surgical treatment of peri-implantitis commonly uses periodontal flap surgery and guided bone regeneration to restore the bone defect [ 11 – 15 ]. Although the above methods have achieved positive therapeutic effects, mechanical debridement may cause damage to the surface properties of the dental implants, and the use of antibiotics may cause bacterial resistance [ 11 , 16 , 17 ]. Besides, the elimination of biofilm only removed inflammatory stimuli in the surrounding microenvironment but did not completely improve the local inflammation in the jaw caused by bacterial infection [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Biomaterials science and surface engineering strategies for dental peri-implantitis management

Yu,

Lu,

Zhang

et al. 2024

Military Med Res

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Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antibacterial properties, and bacterial colonization and biofilm formation on the dental implants are major causes of peri-implantitis. Treatment strategies such as mechanical debridement and antibiotic therapy have been used to remove dental plaque. However, it is particularly important to prevent the occurrence of peri-implantitis rather than treatment. Therefore, the current research spot has focused on improving the antibacterial properties of dental implants, such as the construction of specific micro-nano surface texture, the introduction of diverse functional coatings, or the application of materials with intrinsic antibacterial properties. The aforementioned antibacterial surfaces can be incorporated with bioactive molecules, metallic nanoparticles, or other functional components to further enhance the osteogenic properties and accelerate the healing process. In this review, we summarize the recent developments in biomaterial science and the modification strategies applied to dental implants to inhibit biofilm formation and facilitate bone-implant integration. Furthermore, we summarized the obstacles existing in the process of laboratory research to reach the clinic products, and propose corresponding directions for future developments and research perspectives, so that to provide insights into the rational design and construction of dental implants with the aim to balance antibacterial efficacy, biological safety, and osteogenic property.

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Effects of implant surface mechanical instrumentation methods on peri-implantitis: An in vitro study using a circumferential bone defect model

Cited by 6 publications

References 31 publications

Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications

Research Progress on the Preparation Process and Material Structure of 3D-Printed Dental Implants and Their Clinical Applications

UiO-66/AgNPs Coating for Dental Implants in Preventing Bacterial Infections

Biomaterials science and surface engineering strategies for dental peri-implantitis management

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