Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice

Abstract

RationaleImperatorin, a naturally occurring furanocoumarin, inactivates gamma-aminobutyric acid transaminase and inhibits acetylcholinesterase activity.ObjectivesThe purpose of our experiment was to examine the influence of imperatorin on cognitive impairment and oxidative stress in the brain induced by scopolamine in male Swiss mice.MethodsIn the present studies, we used scopolamine-invoke memory deficit measured in passive avoidance (PA) paradigm as an animal model of Alzheimer disease (AD).ResultsOur finding revealed that imperatorin administered acutely at the doses of 5 and 10 mg/kg prior to the injection of scopolamine (1 mg/kg) improved memory acquisition and consolidation impaired by scopolamine. Furthermore, repeatable (7 days, twice daily) administration of the highest dose of imperatorin (10 mg/kg) significantly attenuated the effects of scopolamine on memory acquisition, whereas the doses of 5 and 10 mg/kg of this furanocoumarin were effective when memory consolidation was measured. Imperatorin, administered with scopolamine, increased antioxidant enzymes activity and decreased concentration of malondiamide, an indicator of lipid peroxidation level.ConclusionsThese results demonstrate that imperatorin may offer protection against scopolamine-induced memory impairments and possesses antioxidant properties, thus after further preclinical and clinical studies this compound may provide an interesting approach in pharmacotherapy, as well as prophylactics of AD.

Imperatorin inhibits allergic airway inflammatory reaction and mucin secretion in ovalbumin-induced asthmatic rats

“…Imperatorin (IPT, Figure 1) is a natural constituent commonly existing in plants of the Umbelliferae family, such as Peucedanum praeruptorum and Angelica dahurica [8]. IPT shows a broad pharmacological activities including anti-seizure, vasodilatation, antitumor, antimicrobial, anti-inflammatory, and analgesic effects [8][9][10]. However, to the best of our knowledge, there is no information on the effects of IPT on allergic asthma.…”

Oxidative Stress in Neurodegenerative Diseases

“…MDA, HNE, or TBARS were enhanced in all of those models in the cerebral cortex or/and hippocampus or/and the whole brain [237][238][239][240][241][247][248][249][250][251][252][253][254][255]. Oxidative modification of proteins has also been demonstrated in the cortex and whole brain homogenate of transgenic AD mice [253,255] and in the cerebral cortex and hippocampus of an Aβ 1-42 mouse model [247].…”

“…Furthermore, the activities of enzymes connected with GSH metabolism, such as GPx and GR, and the enzymes involved in antioxidant defense (SOD and CAT) were reduced in the hippocampus and cerebral cortex in pharmacological and genetic models [237,238,241,248,249,[254][255][256]. It should be noted that some studies demonstrated no change in CAT and SOD activity in whole brain lysates in Wistar rats in the streptozotocin model [240], while enhanced SOD, GPx, and GR were observed in the mouse cerebral cortex and hippocampus following i.c.v.…”

The Optimum Extraction Process for Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook with Orthogonal Design

“…Therefore, the representative extract of liquiritin and imperatorin lays an anti-inflammatory medicinal material foundation for development of the Fengshiding dropping pill. In addition, several methods, including organic solvent extraction, microwave-assisted extraction, 5 and ultrasonicassisted extraction (UAE), 6 have been widely employed for the extraction of single herb. However, few reports have focused on combination extraction process of Radix glycyrrhizae and Angelica dahurica (Fisch.)…”