Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model

Wu, Chia-Ta; Chen, Peng-Jung; Lee, Yu-Tzu; Ko, Jiunn‐Liang; Lue, Ko-Haung

doi:10.1016/j.jmii.2014.08.001

Cited by 91 publications

(76 citation statements)

References 57 publications

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“…The specific mechanism of action of NCC 2287 during allergy treatment is not known. In general, probiotic effects on allergic inflammation are mainly attributed to their capacity to increase the CD4 + CD25 + Foxp3 + regulatory T‐cell pool in peripheral lymph nodes , to decrease sensitization efficacy and/or to modulate cytokine expression . While T regulatory cells have been associated with decreased esophageal eosinophilia in another EoE model , it has recently been shown that other regulatory mechanisms may be involved.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of Lactococcus lactis NCC 2287 in a murine model of eosinophilic esophagitis

Holvoet

Doucet‐Ladevèze

Perrot

et al. 2016

Allergy

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Section: Discussionmentioning

confidence: 99%

Beneficial effect of Lactococcus lactis NCC 2287 in a murine model of eosinophilic esophagitis

Holvoet

Doucet‐Ladevèze

Perrot

et al. 2016

Allergy

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“…Treatment with LGG has been shown to decrease MMP9 expression in lung tissue and to inhibit inflammatory cell infiltration. In addition, in OVA-sensitized mice, LGG reduced OVA-specific IgE levels in serum, suppressed the airway hyper-responsiveness to methacholine and decreased the number of infiltrating inflammatory cells and Th2 cytokines in bronchoalveolar lavage fluid and serum (31). Similar results have been reported with other probiotics (32).…”

Section: Probiotics For Prevention Of Asthma and Eczemamentioning

confidence: 99%

Probiotics in Asthma and Allergy Prevention

et al. 2017

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Interest in probiotic research and its potential benefits in infant foods are relatively recent but significantly increasing. The evolution of the knowledge in the last 20 years demonstrated that alterations in the microbiome may be a consequence of events occurring during infancy or childhood, including prematurity, cesarean section, and nosocomial infections. Several pieces of evidence prove that a “healthy” intestinal microbiota facilitates the development of immune tolerance. Interventional studies suggest that probiotics could be protective against the development of many diseases. Nevertheless, many factors complicate the analysis of dysbiosis in subjects with food allergy. Comparison in-between studies are difficult, because of considerable heterogeneity in study design, sample size, age at fecal collection, methods of analysis of gut microbiome, and geographic location. Currently, there is no positive recommendation from scientific societies to use pre- or probiotics for treatment of food allergy or other allergic manifestations, while their use in prevention is being custom-cleared. However, the recommendation is still based on little evidence. Although there is valid scientific evidence in vitro, there is no sufficient information to suggest the use of specific probiotics in allergy and asthma prevention.

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“…113 Oral administrations of Lactobacillus rhamnosus attenuates OVA-induced airway inflammation. 114 Also, L. casei and L. acidophilus diminish arthritic symptoms in the collagen-induced arthritis model by inhibiting proinflammatory cytokines and inducing anti-inflammatory cytokines. 115 …”

Section: Microbiota-target Treatmentmentioning

confidence: 99%

The interplay between host immune cells and gut microbiota in chronic inflammatory diseases

2017

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Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bacteria modulates host metabolic and immune functions, summarize studies that examined the roles of gut dysbiosis in chronic inflammatory diseases, and finally discuss measures to correct gut dysbiosis as potential therapeutics for chronic inflammatory diseases.

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Effects of immunomodulatory supplementation with Lactobacillus rhamnosus on airway inflammation in a mouse asthma model

Abstract: LGG had an anti-inflammatory effect on OVA-induced airway inflammation and might be an additional or supplementary therapy for allergic airway diseases.

Cited by 91 publications

References 57 publications

Beneficial effect of Lactococcus lactis NCC 2287 in a murine model of eosinophilic esophagitis

Beneficial effect of Lactococcus lactis NCC 2287 in a murine model of eosinophilic esophagitis

Probiotics in Asthma and Allergy Prevention

The interplay between host immune cells and gut microbiota in chronic inflammatory diseases

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