Effects of imidacloprid-contaminated feed exposure on spermatogenic cells and Leydig cells in testes of adult male rabbits (Oryctolagus cuniculus)

The adverse role of endocrine disrupting chemicals in the reproductive system

“…Furthermore, amitraz (AMZ), a formamidine pesticide widely used as an insecticide and acaricide, has been shown to induce alterations in bovine sperm, potentially affecting male fertility at concentrations found in the environment ( 307 ). Similarly, exposure to other pesticides such as diazinon (DZN) ( 308 ), pyridaben (PDB) ( 309 ), bifenthrin (BF) ( 310 ), flurochloridone (FLC) ( 311 ), fipronil (FPN) ( 312 ), etoxazole (ETX) ( 313 ), imidacloprid (IMI) ( 314 , 315 ), atrazine (ATR) ( 316 , 317 ), cypermethrin (CYP) ( 314 , 318 ), chlorpyrifos (CPF) ( 314 , 319 – 322 ), chlorpyrifos ( 323 , 324 ), simazine ( 325 ), endosulfan ( 191 ), and deltamethrin ( 318 ) could lead to a significant decrease in sperm count, motility, normality, vitality, and an increase in deformity rates. Moreover, a significant decrease in daily sperm production, epididymal sperm count, motile, viable, and hypo-osmotic swelling-tail swelled sperm was observed in mancozeb-treated rats ( 326 ).…”

Long Term Administration of <i>Lannea acida</i> Rich. (Anacardiaceae) Reverses the Imidacloprid-Induced Fertility Impairments in Adult Male Rat through Androgenic and Antioxidant Properties

“…Experimental studies have revealed the harmful impact of IMI in mammals and especially on the reproductive system. Testicular damage, sexual hormone imbalance, altered spermatogenesis and testicular DNA damage are the main impairments of IMI on the reproductive system and which may lead to infertility [12] [13] [14]. The mechanism underlining these effects remains unclear but, many reports suggest of a specific action through interaction with mammals nAChRs [15] [16] and a common nonspecific pathway through oxidative stress, resulting from the generation of reactive oxygen species [2] [6] [17].…”

Effects of exposure to imidacloprid contaminated feed on the visceral organs of adult male rabbits (Oryctolagus cuniculus)

“…In male mice, IMI has been demonstrated to cause oxidative stress ( El-Gendy et al, 2010 ); as well as being hepatotoxic and gonadotoxic ( Arfat et al, 2014 , Mohamed et al, 2009 ; Yang et al, 2020 ). The spermatogenic and interstitial or Leydig cell populations in adult male rabbits are toxicologically affected by IMI ( Kobir et al, 2022 ).…”