Effects of imatinib on breast cancer cell biology in vitro

Mundhenke, Christoph; Weigel, Marion T.; Schmidt, S. R.; Meinhold‐Heerlein, Ivo; Schem, Christian; Bauerschlag, DO; Jonat, W.; Maass, Nicolaì

doi:10.1200/jco.2005.23.16_suppl.3210

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2019

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“…For example, imatinib has been shown to have anti-proliferative, cytostatic and apoptotic effect due to its ability to block the platelet derived growth factor receptor (PDGF-Rβ). [53][54][55][56][57] Additionally, tamoxifen has been shown to induce apoptosis mediated by an oestrogen-independent pathway in triple negative breast cancer cell lines (MDA-MB-231, MDA-MB-468, MDA-MB-453 and SK-BR-3). 58,59 Doxorubicin is a DNA alkylator which is used in the treatment of triple negative breast cancer and its activity against MDA MB 231 is well documented.…”

Section: Resultsmentioning

confidence: 99%