Effects of IGN-2098, a new histamine H2-receptor antagonist, on gastric secretion and gastric and duodenal lesions induced in rats. Comparison with roxatidine.

Okabe, Susumu; Narita, Mitsuhiro; Nakaji, Shigeru; Takinami, Yusuke; Kawano, Osamu; Misaki, Noriyuki

doi:10.1254/fpj.99.167

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…However, this apparent curative effect of famotidine was not observed histopathologically even at 100 mg/kg. Okabe and Nobuhara (21) reported that oral administration of famotidine at 60 mg/kg twice daily for 14 days did not accelerate the healing of gastric ulcers induced by 40 ,u 1 of 20% acetic acid but that at 200 mg/kg twice daily, the ulcer size was reduced by 22%. The results as to the curative effect of cimetidine are not consistent.…”

Section: Discussionmentioning

confidence: 98%

Effects of a Proton Pump Inhibitor, AG-1749 (Lansoprazole), on Reflux Esophagitis and Experimental Ulcers in Rats.

et al. 1991

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ABSTRACT-The effects of (±)-2- [[[3-methyl-4-(2,2,2-trifluoroethoxy-2-pyridyljmethyl]-sulfinyl]-1H-benzimidazole (lansoprazole, AG-1749) and famotidine on various experimental ulcers in rats were compared. AG-1749 inhibited reflux esophagitis; gastric lesions induced by water-immersion stress, aspirin or ethanol; and duodenal ulcers induced by cysteamine or mepirizole in a dose-dependent manner: the ID50 values were 0.7, 2.4, 0.7, 8.5, 1.1 and 0.3 mg/kg, p.o. or i.d., respectively. Famotidine inhibited reflux esophagitis with an ID50 value of 12.9 mg/kg, but did not cause 50% inhibition of ethanol-induced gastric lesions even at 100 mg/kg, although it showed almost the same or a little stronger potency on other experimental ulcers: ID50 values were 0.3 -1.4 mg/kg. Significant aggravation of ethanol-or water-immersion stress-induced lesions was observed in rats given famotidine at 30 mg/kg twice daily for 4 days, but not in rats given AG-1749 at 10 mg/kg twice daily. Administration of AG-1749 for 14 consecutive days markedly accelerated the healing of acetic acid-induced gastric and duodenal ulcers, and the healing effect was significant at 10 and 30 mg/kg/day, p.o. Famotidine also accelerated the healing of ulcers, but its potency was less than that of AG-1749. The results of this study indicate that although AG-1749 is slightly less potent than famotidine in inhibiting acutely induced gastroduodenal lesions, this agent is superior to famotidine in promoting the healing of ulcers and in inhibiting reflux esophagitis and ethanol-induced gastric lesions.

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Section: Discussionmentioning

confidence: 98%

Effects of a Proton Pump Inhibitor, AG-1749 (Lansoprazole), on Reflux Esophagitis and Experimental Ulcers in Rats.

et al. 1991

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“…The experiment was performed according to the method of Okabe et al [13]. Seven-week-old male Wistar ST rats were fasted for 18 h. A test drug was given, and then histamine (400 mg/ kg) was given intraperitoneally 30 min later.…”

Section: Histamine-induced Gastric Ulcersmentioning

confidence: 99%

Gastric Antisecretory and Anti-ulcer Effect of ME3407, a New Benzimidazole Derivative, in Rats

Tanaka¹,

Iida²,

Abe³

et al. 2011

Arzneimittelforschung

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The effects of a new benzimidazole derivative, ME3407 (n-butyl-2-(thiazolo-[5,4-b]pyrid-2-yl) sulfinylacetate, CAS 133903-90-9), on gastric acid secretion and gastric and duodenal ulcers in rats were examined. ME3407, given orally, inhibited dose-dependently (0.3-30 mg/kg) the incidence of gastric lesions such as Shay ulcers, and water-immersion stress-, acetylsalicylic acid (ASA)- and histamine-induced erosions. In addition, ME3407 showed marked therapeutic effect on HCl- and ASA-induced lesions. In the lumen-perfused rats, oral administration of ME3407 inhibited dose-dependently (1-100 mg/kg) gastric acid secretion induced by histamine and tetragastrin with ED50 values of 3.02 and 3.37 mg/kg, respectively. Oral administration of ME3407 at a dose of 30 mg/kg also inhibited the elevation of serum gastrin level. The development of duodenal ulcers caused by mepirizole and systeamine was also potently inhibited by ME3407 at an oral dose of 0.1-30 mg/kg. However, when given at 30 mg/kg intraduodenally, subcutaneously or intravenously, ME3407 did not inhibit these acutely induced gastric elosion and acid output. ME3407 was not detected in the serum upon oral administration. These results indicated that ME3407 was active only by oral administration, and exerts direct action on the ulcers and acid secretion from the gastric membrane.

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Role of Nitric Oxide and Prostaglandin in the Protective Effect of Pibutidine Hydrochloride, a Novel Histamine H2-Receptor Antagonist, on the Gastric Mucosal Lesions in Rats

Kiuchi¹,

Isobe²,

Kijima³

et al. 1998

General Pharmacology: The Vascular System

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Effects of IGN-2098, a new histamine H2-receptor antagonist, on gastric secretion and gastric and duodenal lesions induced in rats. Comparison with roxatidine.

Cited by 3 publications

References 7 publications

Effects of a Proton Pump Inhibitor, AG-1749 (Lansoprazole), on Reflux Esophagitis and Experimental Ulcers in Rats.

Effects of a Proton Pump Inhibitor, AG-1749 (Lansoprazole), on Reflux Esophagitis and Experimental Ulcers in Rats.

Gastric Antisecretory and Anti-ulcer Effect of ME3407, a New Benzimidazole Derivative, in Rats

Role of Nitric Oxide and Prostaglandin in the Protective Effect of Pibutidine Hydrochloride, a Novel Histamine H2-Receptor Antagonist, on the Gastric Mucosal Lesions in Rats

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