Effects of Ibuprofen on Pulmonary Edema in an Animal Shoke Inhalation Model

Stewart, RJ; Yamaguchi, Kent T.; Knost, PM; Samadani, S.

doi:10.1097/00005373-198807000-00076

The Journal of Trauma: Injury, Infection, and Critical Care

1988

DOI: 10.1097/00005373-198807000-00076

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Effects of Ibuprofen on Pulmonary Edema in an Animal Shoke Inhalation Model

RJ Stewart

Kent T. Yamaguchi

PM Knost

et al.

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“…The anti-inflammatory effects of ibuprofen have been extensively studied in vitro and in animal models. [5][6][7] The pharmacokinetics of ibuprofen have been studied in the pediatric population and in preterm infants. 8 -10 Ibuprofen has been used for the closure of PDA without altering cerebral hemodynamics and oxygenation in preterm infants.…”

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Ibuprofen Use to Reduce the Incidence and Severity of Bronchopulmonary Dysplasia: A Pilot Study

et al. 2000

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Although a trend toward less ventilator and hospital days in the ibuprofen group was observed in this pilot study, the differences were not statistically significant. The incidence of BPD was similar in both groups. In the study group, two infants developed gastrointestinal complications and a third infant experienced reversible renal failure. The plasma ibuprofen levels were low. Further studies are needed to assess the use of ibuprofen for the prevention and/or treatment of BPD in preterm infants.

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Ibuprofen Use to Reduce the Incidence and Severity of Bronchopulmonary Dysplasia: A Pilot Study

et al. 2000

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Effects of Ibuprofen on Pulmonary Edema in an Animal Shoke Inhalation Model

Cited by 1 publication

References 0 publications

Ibuprofen Use to Reduce the Incidence and Severity of Bronchopulmonary Dysplasia: A Pilot Study

Ibuprofen Use to Reduce the Incidence and Severity of Bronchopulmonary Dysplasia: A Pilot Study

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