Effects of Talinum triangulare leaf flavonoid extract on streptozotocin‐induced hyperglycemia and associated complications in rats

Abstract

Talinum triangulare leaf flavonoid extract (TTFE) was evaluated for its effects on streptozotocin‐hyperglycemia and associated complications especially as it relates to dyslipidemia, lipid peroxidation, and renal dysfunction in rats. Two normoglycemic rat groups designated: control (administered distilled water) and control + TTFE (administered 10 mg/kg b.w. TTFE) and two streptozotocin‐induced (STZ) diabetic rat groups designated: STZ‐control (administered distilled water) and STZ + TTFE (administered 10 mg/kg TTFE). The treatment was given orally once daily for 21 consecutive days. Body weight and insulin concentration showed significant improvement while blood glucose, uric acid, creatinine, and total bilirubin concentrations were significantly reduced in diabetic rats administered TTFE compared to diabetic untreated rats. Furthermore, triglycerides, total cholesterol, LDL‐cholesterol, and malondialdehyde concentrations were significantly lowered in diabetic rats administered TTFE compared with diabetic untreated rats. Key enzymes involved in carbohydrate breakdown and cholesterol synthesis, α‐amylase and 3‐hydroxy‐3‐methylglutaryl‐CoA (HMG‐CoA) reductase, respectively, were significantly inhibited in TTFE‐treated diabetic rats compared to diabetic control. Results presented in this study suggest that administration of TTFE for 21 days normalized STZ‐induced hyperglycemia and its associated dyslipidemia by a mechanism involving inhibition of α‐amylase and HMG‐CoA reductase activities, respectively, in rats.

Therapeutic potentials and pharmacological properties of Talinum triangulare (Jacq.) Willd. in the treatment and management of diabetes mellitus and other conditions

“…It was also observed that treatment with extract of T. triangulare for 21 days significantly improved serum insulin level in STZ-induced diabetic rats compared to the untreated diabetic group. Authors equally observed improved kidney function, lipid profile and antioxidant status following the administration of flavonoid fraction from the extract of T. triangulare (27). Also, the inhibitory activity of T. triangulare flavonoids on alpha-amylase activity may have played a role in the reduction of carbohydrate hydrolysis and absorption in the intestine, culminating in the reduction of serum glucose levels in this study (27,61).…”

“…It is cultivated in Nigeria and Cameroon by seedling and cuttings. There are approximately 500 species of the genus Talinum globally (27). T. triangulare is sensitive to cold conditions and its roots will rot when water is logging in the soil.…”

“…Scientific reports tend to show that there are over 400 plant species with hypoglycaemic activity (27,61). Sadly, many of these plant species have not been scientifically validated.…”

“…Medicinal plants are known to elicit various biological and pharmacological reactions (4,27,48). Growing consumers' demand for traditional food supplements stimulated the interest of scientists to examine the possible effects of T. triangulare on cerebral functions in an animal model (63).…”

Attenuation of Alloxan-induced Low-grade Inflammation by Persea Americana Polyphenolic Peel Extract in Male Wistar Rats

“…Given its numerous health bene ts, avocado peel waste is considered a promising, low cost biomass for salvaging phenolic compounds from agro-wastes. Hence, the exploitation of avocado peel waste will go a long way in adding value to avocado processing industry as well served as a veritable strategy for reducing the environmental impacts of avocado wastes 12 . The potential inhibition of α-amylase by certain food and plant extracts was reported recently.…”