Effects of<i>Radix Puerariae</i>flavones on liver lipid metabolism in ovariectomized rats

Wang, Jifeng; Guo, Yanxia; Niu, Jan-Zhao; Liu, Juan; Wang, Ling-Qiao; Li, Peiheng

doi:10.3748/wjg.v10.i13.1967

Cited by 42 publications

(31 citation statements)

References 30 publications

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“…In agreement with our study, OVX mice fed a diet containing Pueraria lobata (20% of diet or equivalent to 7.2 mg isoflavone) for 4 weeks did not show changes in uterine weight (Wang et al, 2003), but it could increase the trabecular bone volume. However, although slightly, the consumption of 100 mg/kg BW of Pueraria lobata for 5 weeks has been proved to significantly (P < 0.05) increase the uterus weight in OVX rats (Wang et al, 2004).…”

Section: Discussionmentioning

confidence: 98%

“…The Pueraria lobata (Leguminosae), also known as Kadzu, is a leguminous plant and possesses a high content of isoflavonoids such as daidzein and genistein (Wang et 2003). As regards to the isoflavonoids contents, Pueraria lobata slightly increased the uterus weight in ovariectomized (OVX) rats (Wang et al, 2003(Wang et al, , 2004 and remarkably increased the bone mineral density in OVX mice (Wang et al, 2003). However, it had neither proliferation nor anti-proliferation effect on growth of MCF-7 in vitro .…”

Section: Introductionmentioning

confidence: 96%

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Using vaginal cytology to assess the estrogenic activity of phytoestrogen-rich herb

Malaivijitnond

Chansri

Kijkuokul

et al. 2006

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 96%

Using vaginal cytology to assess the estrogenic activity of phytoestrogen-rich herb

Malaivijitnond

Chansri

Kijkuokul

et al. 2006

Journal of Ethnopharmacology

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“…10) However, the impact of PFE on body fat is not known. This clinical study was preliminary conducted on eighty mildly obese subjects to view the body fat reducing action of PFE.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Research for the Anti-obesity Effect of Puerariae Flos Extract in Humans

Kamiya

Matsuzuka

Kusaba

et al. 2011

JOURNAL OF HEALTH SCIENCE

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This research is preliminary study to examine whether puerariae flos extract (PFE) makes any action to body fat of man or not. We conducted the double-blind placebo controlled study on eighty mildly obese subjects for 8 weeks. The subjects were randomly divided into 4 groups: I, II, III, and IV. Subjects in groups I, II, and III consumed test food containing 100, 200, and 300 mg PFE, respectively, while those in group IV were given placebo food for 8 weeks. All subjects were instructed to restrict their total-energy intake to within 2650 kcal/day in the case of males and 2300 kcal/day in the case of females during the test period. Haematological and biochemical markers of blood, urinary markers, and physical markers were examined at 0, 4, and 8 weeks during the test period. As a result, no adverse effects were noted in any of the groups. For physical examinations, we analysed only males whose initial body mass index (BMI) values were over 24. BMI value and body weights of the subjects in group III were significantly reduced, and total fat area and subcutaneous fat area of the subjects in groups II and III were significantly reduced over the 8-week test period. Moreover, as a result of comparison among groups by unpaired t-test, significant difference appeared between group III and group IV in BMI. Total fat area in group III tend to decrease compared with group IV. By these results, the reduction of BMI in group III may reflect fat area reduction. To confirm the anti-obesity effect of PFE, we need to research particularly by extensive studies hereafter.

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“…These findings supported the favorable hepatoprotective activity of PCS. Since the liver is the main target organ of HMG-CoA reductase (45,72), hypertrophy and fatty change in hepatocytes are accompanied by increased AST and ALT activities (73,74), which are related to estrogen deficiency-mediated obese and hyperlipidemia (45,74,75). Estrogen deficiency is associated with an atherogenic lipid profile characterized by HDL-cholesterol, LDL-cholesterol, triglyceride levels (11), central adiposity (12), increased diastolic pressure (13), and increased insulin resistance (14).…”

Section: Discussionmentioning

confidence: 99%

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

Kang¹,

Choi²,

Kim³

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. In the present study, the complex anti-climacterium potential of standardized pomegranate concentrated solution (PCS) was investigated using bilateral ovariectomy (OVX) female ddY mice. Changes in body weight and gain during experimental periods, food consumption, serum estradiol levels, total body and abdominal fat densities, abdominal fat pads, and uterus weights were observed, along with the histopathology of abdominal fat pads and uterus for anti-obesity and estrogenic effects. In addition, liver weights, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and histopathological inspections were performed to explore the hepato-protective effects. Serum total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein, and triglyceride (TG) levels were monitored for hypolipidemic effects with total body and femur mean bone mineral density (BMD), right femur wet, dry and ash weights, strength, serum osteocalcin, bone-specific alkaline phosphatase (bALP) contents, and histological and histomorphometrical analyses for anti-osteoporosis activity. As a result of OVX, notable increases in body weight and gains, food consumption, abdominal fat mass densities, weights of abdominal fat pads deposited in the abdominal cavity, and serum AST, ALT, TC, LDL, TG, and osteocalcin levels were observed, along with decreases in the uterus, liver, and femur weights, mean total body and femur BMD, femur strength, serum bALP, and estradiol levels. In addition, marked hypertrophic alterations in adipocytes located in the deposited abdominal fat pads, liver steatosis, uterine disused atrophic changes, and decreases in bone mass and structures of the femur were also observed in OVX control mice with significant increases in bone resorption markers based on histopathological and histomorphometrical analysis. However, these estrogen-deficient climacterium symptoms were significantly (P<0.05 or P<0.01) inhibited after 84 days of continuous treatment with estradiol and PCS (1, 2 and 4 ml/kg), respectively. The present results suggested that PCS was able to effectively inhibit or refine the climacterium symptoms, including obesity, hyperlipidemia, hepatic steatosis, and osteoporosis, induced by OVX in ddY mice.

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Effects ofRadix Puerariaeflavones on liver lipid metabolism in ovariectomized rats

Abstract: RPF has estrogen-like effect on lipid metabolism in liver and adipose tissue.

Cited by 42 publications

References 30 publications

Using vaginal cytology to assess the estrogenic activity of phytoestrogen-rich herb

Using vaginal cytology to assess the estrogenic activity of phytoestrogen-rich herb

Preliminary Research for the Anti-obesity Effect of Puerariae Flos Extract in Humans

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

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