Effects ofPueraria lobataon Obesity Related Hormones in Rats with Estrogen Deficiency

Abstract

Objectives: This study was conducted to evaluate the effects of Pueraria lobata (PL) extract on obesity related hormones in rats with estrogen deficiency. Methods: The experiments were performed with the use of ovariectomized rats as estrogen-deficient obesity rat model. They were grouped Normal (sham operation group), Control (ovariectomy group), 50 mg/kg PL (ovariectomy group＋50 mg/kg of PL), 100 mg/kg PL (ovariectomy group＋100 mg/kg of PL), 200 mg/kg PL (ovariectomy group＋200 mg/kg of PL). PL extract was orally administered for 8 weeks once a day. Body weights and serum levels of hormones, such as leptin, estradiol, cholecystokinin (CCK), ghrelin, and adiponectin were estimated by ELISA. Results: PL extract significantly decreased body weight, the serum levels of leptin in estrogen-deficient obesity rats. PL extract significantly increased the serum levels of estradiol and CCK. However, PL extract did not directly effect on the levels of ghrelin and adiponectin in estrogen-deficient obesity rats. Conclusions: It is concluded that PL extract reduced body weight, and regulate the hormones related to energy metabolism. PL extract decreased the serum levels of leptin. PL extract increased the serum levels of estradiol and CCK. These results indicate that PL might have potentials for treatment of obesity and complications during the menopause caused by estrogen-deficiency.

Effects of Herbal Prescription on Obesity Related Hormones in Rats with Estrogen Deficiency

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Analysis of Research Trends in Papers Published in the Journal of Korean Medicine for Obesity Research: Focused on 2010-2019

“…(1) 동물연구(animal study) 54,55,57,58,61,62,65,66,69,72,73) , 당뇨유도모델을 활 용한 경우가 3편 60,64,68) 이었으며 이상지질혈증을 유도한 경 우는 2편 56,63) , 기타 질환을 유도한 경우는 5편 59,70,71,75,76) 이었 다. 비만관련 지표를 확인한 연구가 총 10편 54,55,57,58,61,62,65,66,69,73) 이었으며 지질대사와 관련한 연구가 6편 56,58,63,73,75,76) , 당대 사의 변화를 확인한 연구가 5편 [64][65][66]68,69) , 경구독성연구가 3편 55,67,74) , 호르몬 관련 연구가 2편 59,70) , 위장관 운동 관련 연구가 2편 60,68) 54,67,…”