Effects of Lactobacillus acidophilus and inulin on faecal viral shedding and immunization against H₉ N₂ Avian influenza virus

Abstract

Aims: The aims of this investigation were to compare the effects of Lactobacillus acidophilus addition as simple or microencapsulated (ME) probiotic and inulin as prebiotic to the broiler diet on the faecal viral shedding and immunization against avian influenza virus (AIV) with or without H 9 N 2 vaccination. Methods and Results: Simple or ME forms of Lact. acidophilus, inulin and combination of them as synbiotic were analysed for their ability to enhance immunity against H 9 N 2 AIV and to decrease faecal viral shedding in Cobb-500 broiler chicks. Our results indicated that probiotic as ME form can decrease haemagglutination inhibition (HI) titre significantly on days 34 in vaccinated trial (P < 0Á05). Also, the effects of ME form of probiotic are more remarkable on reduction of viral faecal shedding detected by RT-PCR. Conclusions: The study shows the significant role of microencapsulation on probiotic effects against H 9 N 2 AIV. Significance and Impact of the Study: The application of probiotics especially in the ME form could have the potential for stimulating the immune system, preventing influenza infection and consequently reduce faecal viral shedding of H 9 N 2 AIV.

The immunomodulatory effects of probiotics on respiratory viral infections: A hint for COVID-19 treatment?

“…Regarding other animal models, Poorbaghi et al showed that microencapsulated Lactobacillus acidophilus probiotic and its symbiotic form with inulin decreased faecal shedding of H9N2 avian influenza virus (AIV) in both non-vaccinated and vaccinated broiler chicks [ 62 ]. In another study, Enterococcus faecalis-1 has been proved to improve the body weight and feed conversion ratio of treated broilers, and also significantly elevated the total IgY serum level, resulting in efficient modulation of the cecal microbiota and decrease in the mortality percentage of broilers [ 63 ].…”

Synbiotics and Immunization Against H9N2 Avian Influenza Virus

“…Also, the effects of ME form of probiotic are more remarkable in the reduction of viral fecal shedding detected by RT-PCR (Poorbaghi et al, 2014). In this study, simple or ME forms of L. acidophilus, inulin, and a combination of them as synbiotic were analyzed for their ability to enhance immunity against H 9 N 2 AIV and to decrease fecal viral shedding in Cobb-500 broiler chicks.…”

Probiotic Potential of Five Lactobacillus Strains Isolated from Traditional Persian Yoghurt in Fars province, Iran: Viewing Through the Window of Phylogenetics

“…These bacteria are considered as generally recognized as safe (GRAS) microorganisms and can be safely used for medical and veterinary applications (Fuller, 1989). Lactobacilli are important organisms recognized for their fermentative ability as well as their health and nutritional benefits (Poorbaghi et al, 2014). They produce various compounds such as organic acids, diacetyl, hydrogen peroxide, bacteriocin and other bactericidal proteins during lactic fermentations (Ravi et al, 2011).…”