Effects of
            <i>IGF2BP2, KCNQ1</i>
            and
            <i>GCKR</i>
            Polymorphisms on Clinical Outcome in Metastatic Gastric Cancer Treated with EOF Regimen

Liu, Xin; Chen, Zhiyu; Zhao, Xiaoying; Huang, Mingzhu; Wang, Chenchen; Peng, Wei; Yin, Jun; Li, Jin; He, Guang; Li, Xin; Zhu, Xiaoyan

doi:10.2217/pgs.15.49

Cited by 34 publications

(21 citation statements)

References 36 publications

(38 reference statements)

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“…Its amplification and overexpression in many cancers correlate with cancer progression and predict poor prognosis. Secondly, IGF2BP2 promotes cancer cell survival, proliferation, and migration although the underlying mechanisms remain poorly defined [ 28 , 29 , 39 ]. Thirdly, in vitro and in vivo studies have provided solid evidence that IGF2BP2 is a dominant factor in the self-renewal of CSCs [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Alterations in the IGF2BP2 gene may have potential prognostic value in gastrointestinal cancer. In gastric cancer patients treated by first-line combinational therapy with epirubicin, oxaliplatin, and 5-fluorouracil, IGF2BP2 polymorphisms rs4402960 and rs6769511 are less common in patients with disease progression than in those with controlled disease [ 28 ]. Whether these nucleotide changes improve the response of gastric cancer patients to chemotherapies remains to be confirmed in future studies.…”

Section: Association Of Igf2bp2 With Cancermentioning

confidence: 99%

“…However, an inverse correlation between this polymorphism and prostate cancer was reported [ 145 ]. In gastric cancer, IGF2BP2 rs4402960 and rs6769511 are more often detected in patients responsive to a combinational chemotherapy of epirubicin, oxaliplatin, and 5-fluorouracil [ 28 ]. These findings highlight the importance of these polymorphisms of IGF2BP2 in diabetes and cancer development; however, how the genetic variations affect the expression of IGF2BP2 and IGF2 is uncertain, and their functional consequences in diabetes and cancer progression require further characterization.…”

Section: Igf2bp2 Diabetes and Cancermentioning

confidence: 99%

“…Indeed, overexpression of IGF2BP2 in basal-like breast cancer and esophageal adenocarcinoma predicts short survival of the patients [ 25 – 27 ]. At the cellular level, IGF2BP2 enhances genomic instability [ 27 ] and stimulates cancer cell proliferation and migration [ 28 , 29 ]. Furthermore, studies from independent laboratories suggest that IGF2BP2 participates in the maintenance of cancer stem cells (CSCs) [ 17 , 27 , 30 ], implicating that IGF2BP2 may be important for the chemoresistance and recurrence of the diseases.…”

Section: Introductionmentioning

confidence: 99%

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The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Cao

Huang

2018

Stem Cells International

124

128

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RNA-binding proteins (RBPs) mediate the localization, stability, and translation of the target transcripts and fine-tune the physiological functions of the proteins encoded. The insulin-like growth factor (IGF) 2 mRNA-binding protein (IGF2BP, IMP) family comprises three RBPs, IGF2BP1, IGF2BP2, and IGF2BP3, capable of associating with IGF2 and other transcripts and mediating their processing. IGF2BP2 represents the least understood member of this family of RBPs; however, it has been reported to participate in a wide range of physiological processes, such as embryonic development, neuronal differentiation, and metabolism. Its dysregulation is associated with insulin resistance, diabetes, and carcinogenesis and may potentially be a powerful biomarker and candidate target for relevant diseases. This review summarizes the structural features, regulation, and functions of IGF2BP2 and their association with cancer and cancer stem cells.

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Section: Discussionmentioning

confidence: 99%

Section: Association Of Igf2bp2 With Cancermentioning

confidence: 99%

Section: Igf2bp2 Diabetes and Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Cao

Huang

2018

Stem Cells International

124

128

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“…Gastric carcinoma is one of the common types of malignant tumor that threaten human life and health ( 1 ). Gastric carcinoma has low eradication rates during surgery, with high recurrence and metastasis rates following surgery ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Lily extracts inhibit the proliferation of gastric carcinoma SGC‑7901 cells by affecting cell cycle progression and apoptosis via the upregulation of caspase‑3 and Fas proteins, and the downregulation of FasL protein

Wang

Pang

et al. 2018

Oncol Lett

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The present study aimed to investigate the effect of alkaloids and carbinol extracts from lily on the proliferation of SGC-7901 cells, as well as the underlying mechanism. SGC-7901 cells were incubated with different concentrations of alkaloid or carbinol extracts for 24, 48 or 72 h. MTT assays were used to measure the inhibition rate of SGC-7901 cell proliferation. Inverted phase contrast and fluorescence microscopy was used to observe morphological changes of SGC-7901 cells. Flow cytometry was employed to detect cell cycle progression and apoptosis rates of SGC-7901 cells. Western blotting was performed to measure the expression of caspase-3, Fas and Fas ligand (FasL) proteins in SGC-7901 cells. The inhibition rate of SGC-7901 cell proliferation was significantly enhanced with increasing drug concentrations and time elapsed. Treatment with alkaloid or carbinol extracts deteriorated the morphology of SGC-7901 cells in a dose-dependent manner. Alkaloid and carbinol extracts arrested SGC-7901 cells in the G2/M phase, and induced apoptosis in a dose-dependent manner. Alkaloid and carbinol extracts enhanced caspase-3, and Fas expression, but reduced FasL expression in SGC-7901 cells. The present study demonstrated that alkaloids and carbinol extracts from lily inhibited the proliferation of gastric carcinoma SGC-7901 cells by arresting cells in the G2/M phase. The upregulation of caspase-3 and Fas proteins, and the downregulation of FasL protein may be an important mechanism for the induction of SGC-7901 cell apoptosis.

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IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF‐1 degradation by miR‐195

Song

Song²,

et al. 2016

FEBS Letters

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Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is a post-transcriptional regulatory factor implicated in mRNA localization, stability, and translational control. However, the role of IGF2BP2 regulation in colorectal cancer (CRC) and its underlying mechanism remain elusive. In this study, we found that IGF2BP2 expression is markedly increased in CRC tissues. Notably, IGF2BP2 overexpression strikingly enhanced the proliferation and survival of CRC cells in vitro, whereas its shRNA-mediated silencing resulted in the opposite. Molecular function analyses revealed that IGF2BP2 regulates RAF1 expression through blocking its degradation by miR-195. These results identify IGF2BP2 as a post-transcriptional regulatory mRNAbinding factor that contributes to CRC carcinogenesis.

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Effects of IGF2BP2, KCNQ1 and GCKR Polymorphisms on Clinical Outcome in Metastatic Gastric Cancer Treated with EOF Regimen

Cited by 34 publications

References 36 publications

The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

Lily extracts inhibit the proliferation of gastric carcinoma SGC‑7901 cells by affecting cell cycle progression and apoptosis via the upregulation of caspase‑3 and Fas proteins, and the downregulation of FasL protein

IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering with RAF‐1 degradation by miR‐195

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