Effects of<i>hsa_circRBM23</i>on Hepatocellular Carcinoma Cell Viability and Migration as Produced by Regulating miR-138 Expression

Wang, Baoyong; Chen, Hongwei; Zhang, Chunfen; Tian, Yue; Zhao, Qiaofei; Yan, Yifan; Xu, Feng

doi:10.1089/cbr.2017.2424

Cited by 20 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent circRNA profiling study showed that circRBM23 expression was upregulated, whereas miR-138 expression was decreased, in HCC tissues. Downregulation of circRBM23 decreased cell viability, proliferation, and migration and promoted the expression of miR-138 and its related target genes vimentin and CCND3 [103]. Thus, the circRNA-miRNA-vimentin regulatory axis in EMT is important for tumor invasion and metastasis.…”

Section: Regulation Of Cell Adhesion Molecules and Cytoskeletal Protementioning

confidence: 98%

Functional roles of circular RNAs during epithelial-to-mesenchymal transition

Shang¹,

Li²,

Quan³

et al. 2019

Mol Cancer

View full text Add to dashboard Cite

Cancer has become a major health issue worldwide, contributing to a high mortality rate. Tumor metastasis is attributed to the death of most patients. Epithelial-to-mesenchymal transition (EMT) plays a vital role in inducing metastasis. During EMT, epithelial cells lose their characteristics, such as cell-to-cell adhesion and cell polarity, and cells gain motility, migratory potential, and invasive properties to become mesenchymal stem cells. Circular RNAs (circRNAs) are closely associated with tumor metastasis and patient prognosis, as revealed by increasing lines of evidence. CircRNA is a type of single-stranded RNA that forms a covalently closed continuous loop. CircRNAs are insensitive to ribonucleases and are widespread in body fluids. This work is the first review on EMT-related circRNAs. In this review, we briefly discuss the characteristics and functions of circRNAs. The correlation of circRNAs with EMT has been reported, and we discuss the ways circRNAs can regulate EMT progression through EMT transcription factors, EMT-related signaling pathways, and other mechanisms. This work summarizes current studies on EMTrelated circRNAs in various cancers and provides a theoretical basis for the use of EMT-related circRNAs in targeted management and therapy.

show abstract

Section: Regulation Of Cell Adhesion Molecules and Cytoskeletal Protementioning

confidence: 98%

Functional roles of circular RNAs during epithelial-to-mesenchymal transition

Shang¹,

Li²,

Quan³

et al. 2019

Mol Cancer

View full text Add to dashboard Cite

show abstract

“…CircRBM23 was found to be abundantly expressed in HCC tissues [ 80 ]. CircRBM23 upregulation was able to increase cell viability and elevate the migratory capability of HCC cells.…”

Section: The Functional Roles Of Circrnas In Hccmentioning

confidence: 99%

Circular RNAs: Characteristics, Function and Clinical Significance in Hepatocellular Carcinoma

Wang

2018

Cancers

111

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. HCC patients are commonly diagnosed at an advanced stage, for which highly effective therapies are limited. Moreover, the five-year survival rate of HCC patients remains poor due to high frequency of tumor metastasis and recurrence. These challenges give rise to the emergent need to discover promising biomarkers for HCC diagnosis and identify novel targets for HCC therapy. Circular RNAs (circRNAs), a class of long-overlook non-coding RNA, have been revealed as multi-functional RNAs in recent years. Growing evidence indicates that circRNA expression alterations have a broad impact in biological characteristics of HCC. Most of these circRNAs regulate HCC progression by acting as miRNA sponges, suggesting that circRNAs may function as promising diagnostic biomarkers and ideal therapeutic targets for HCC. In this review, we summarize the current progress in studying the functional role of circRNAs in HCC pathogenesis and present their potential values as diagnostic biomarkers and therapeutic targets. In-depth investigations on the function and mechanism of circRNAs in HCC will enrich our knowledge of HCC pathogenesis and contribute to the development of effective diagnostic biomarkers and therapeutic targets for HCC.

show abstract

“…After re-analysis, we selected 8 markedly differential expressed circRNAs in all the three datasets (Fig.1A, S1A and Table S2-4). Due to 4 of these 8 circRNAs were deeply reported in HCC 15–18 , we then detected the expressions of the other 4 circRNAs by using 10 pairs of human tissues (HCC tissues vs. the correspondent non-tumor adjacent tissues). We found that circMRPS35 was the most significantly different expressed in HCC tissues (Fig.S1B).…”

Section: Resultsmentioning

confidence: 99%

circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer

Song

Liu

et al. 2021

Preprint

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC), a common malignant tumor, is one of the main causes of cancer-related deaths worldwide. Circular RNAs (circRNAs), a novel class of non-coding RNA, have been reported to be involved in the etiology of various malignancy. However, the functions of circRNAs in HCC remain unclear. In this study, through mining the RNA sequencing databases from GEO datasets and subsequent experimental verification, we identified that hsa_circ_0000384 (circMRPS35) was highly expressed in HCC. Knockdown of circMRPS35 suppressed the proliferation, migration, invasion, clone formation and cell cycle of HCC cell lines both in vitro and in a xenograft mouse model. Mechanically, circMRPS35 sponged microRNA-148a-3p (miR-148a), which in turn regulated STX3-PTEN axis. Surprisingly, we detected a peptide encoded by circMRPS35 (circMRPS35-168aa), which was significantly induced by chemotherapeutic drugs and promoted cisplatin resistance in HCC cells. These results demonstrated that circMRPS35 might be a novel factor in HCC progress, and has a great potential as a new diagnosis and therapeutic target for treatment of HCC.

show abstract

Effects ofhsa_circRBM23on Hepatocellular Carcinoma Cell Viability and Migration as Produced by Regulating miR-138 Expression

Cited by 20 publications

References 26 publications

Functional roles of circular RNAs during epithelial-to-mesenchymal transition

Functional roles of circular RNAs during epithelial-to-mesenchymal transition

Circular RNAs: Characteristics, Function and Clinical Significance in Hepatocellular Carcinoma

circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer

Contact Info

Product

Resources

About