Effects ofHimatanthus lancifoliuson Human Leukocyte Chemotaxis and their Adhesion to Integrins

Abstract

The aim of this work was to investigate the anti-inflammatory activities of the uleine-rich fraction extracted from the barks of Himatanthus lancifolius (Muell. Arg.) Woodson (Apocynaceae). To achieve this, we focused on its in vitro effects on some steps of the inflammatory response using peripheral human leukocytes. The results presented herein show that the uleine-rich fraction significantly inhibits the migration of casein-induced granulocytes and their adhesion to fibronectin and vitronectin, along with mononuclear cells, by down-regulating the expression of alpha 4beta1 and alpha5beta1 integrins. The data suggest that H. LANCIFOLIUS has the potential of interferring with leukocyte trafficking through its uleine-rich fraction, emphasizing its usefulness in inflammatory conditions. DEXA:dexamethasone disodium phosphate FN:fibronectin PMN:polymorphonuclear URF:uleine-rich fraction VN:vitronectin.

Plant-derived acetylcholinesterase inhibitory alkaloids for the treatment of Alzheimer's disease

“…[27][28][29][30] Furthermore, this alkaloid and its related derivatives were also studied for their anticancer properties, 30 and, more recently, alkaloids-enriched fractions were also studied for their in vitro anti-inflammatory properties. 31 It was reported recently that uleine has significant AChE-I activity with an IC 50 of 0.45 µM. 26 For this reason, uleine is considered as a new possible candidate for the future development of new anti-AD drugs, but no reports about safety, efficacy, and human studies specific to cognition have been reported to date.…”

Himatanthus lancifolius (Müll. Arg.) Woodson, Apocynaceae: estudo farmacobotânico de uma planta medicinal da Farmacopeia brasileira 1ª edição

“…As cascas do caule de H. lancifolius caracterizamse pela presença de alcaloides indólicos, tais como uleína, ioimbina, epiuleína e demetoxiaspidospermina (França et al, 2000;Souza, 2007;Lopes, 2008). As frações ricas em alcaloides indólicos das cascas, assim como os compostos isolados, mostraram-se significativamente ativos, apresentando atividades antimicrobiana (Souza et al, 2004), antiespasmódica (Rattmann et al, 2005, gastroprotetora (Baggio et al, 2005) e antiinflamatória (Nardin et al, 2009). O látex extraído do caule é considerado anti-helmíntico e febrífugo, enquanto que as folhas são popularmente indicadas por sua propriedade galactagoga (Côrrea, 1926) e a raiz é utilizada para o tratamento de afecções do útero e dos ovários (Plumel, 1991).…”

Aspidosperma subincanum II. Usefulness of uleine and ribonucleic fragments in the treatment of AIDS patients

“…Yet, PP80 given alone to them in addition to tri-therapy improved considerably their health. An explanation for this remarkable effect may be found in the fact that uleine also interferes with the inflammatory response (Nardin et al, 2008) and regulates the immune system (Nardin et al, 2010). The substance possesses thus properties shared by the two other regimen proposed.…”