Effects ofH pyloritherapy on erythrocytic and iron parameters in iron deficiency anemia patients withH pylori-positive chronic gastristis

Abstract

AIM: To elucidate the influences of H pylori infection on oral iron treatment for iron deficiency anemia (IDA). METHODS:A total of 86 patients were divided into two groups: group A, receiving ferrous succinate combined with triple therapy for H pylori eradication, and group B (control), treated with ferrous succinate only. During treatment of IDA, dynamic changes in hemoglobin (Hb) level, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), serum iron (SI), and serum ferritin (SF) were compared between the groups. RESULTS:Hb was slightly higher in group A at d 14 after the start of triple therapy for H pylori eradication (P > 0.05). After the therapy, the increase of Hb in group A became significantly faster than that in group B (P < 0.05). At d 56, the mean Hb in group A returned to the normal level, however, in group B, it was lower than that in group A (P < 0.05) although it had also increased compared with that before oral iron treatment. The MCV and MCH in group A recovered to the normal level, and were much higher than those in group B (P < 0.05) at d 21. In Group B, the MCV and MCH remained at lower than normal levels until d 42 after the start of therapy. And then, they reached a plateau in both groups and the differences disappeared (P > 0.05). The SF in group A was higher than that in group B (P < 0.05) 28 d after the treatment and its improvement was quicker in group A (P < 0.05) , and the difference between the two groups was even more significant (P < 0.01) at d 56. The SI in group A was higher than that in group B (P < 0.05) at d 14 and this persisted until d 56 when the follow-up of this research was finished. CONCLUSION:

The correlation between helicobacter pylori Infection, hyperemesis gravidarum, and anemia among pregnant females … Effect of treatment

“…[8] . Also Chen and Lue, 2007 reached the same result although the study was in non-pregnant females [16] .…”

Awareness of Iron Deficiency Anemia among Women of Reproductive Age in Hubei Province, China

“…3 In certain geographic areas, intestinal parasites, particularly hookworm, worsen the iron deficiency because of blood loss from the gastrointestinal tract. 4,5 It is important economically, because IDA diminishes the capability of individuals in peripheral countryside living areas of rapidly developing countries like China, India and Pakistan to perform physical labor as their source of income, and it diminishes both growth and learning in children.…”

A Systematic Review on Drugs Absorption Modifications after Eradication in Helicobacter pylori Positive Patients undergoing Replacement Therapy

“…A total of seven studies were selected for review of the full paper and data extraction [7][8][9][10][11][12][13]. The high clinical heterogeneity detected in primary studies due to different types of intervention administered, different outcomes described and the low number of identified studies did not allow us to pool data together to produce a summary measure and to perform statistical evaluation.…”

“…All studies that explored the effect of H. pylori eradication on iron absorption concluded that H. pylori infection is associated with a poorer response to oral iron therapy, that its treatment can enhance the efficacy of oral iron replacement therapy and that the screening for this infection should be considered in patients with unexplained or refractory iron deficiency anemia [4,8,16]. Results of the case series performed by Kotb et al (2012) [13] showed a statistically significant increase in haematological indices such as haemoglobin (Hb), serum ferritin (SF) and transferrin saturation (TF) achieved after H. pylori eradication compared to baseline at 6 and 12 weeks post therapy.…”