Effects of<i>Ecballium elatrium</i>Juice on Serum Bilirubin Concentration in Male Rats

Elayan, Hamzeh; Gharaibeh, Munir; Zmeili, S; Salhab, Abdulazim S.

doi:10.3109/13880208909116908

Cited by 13 publications

(7 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rich. (Cucurbitaceae, the squirting cucumber), a Mediterranean medicinal plant that has been investigated for its several pharmacological properties (Basaran et al, 1993;Elayan et al, 1989;Favel et al, 1989;Yesilada et al, 1988), contains a group of compounds collectively termed cucurbitacins. One particular cucurbitacin that has been studied for its cytotoxic activity is cucurbitacin E (CuE), a tetracyclic triterpenoid with a high cytotoxic potential.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Cucurbitacin E on Two Lymphocyte Models

Attard

Cuschieri

Scicluna-Spiteri

et al. 2004

Pharmaceutical Biology

View full text Add to dashboard Cite

Cucurbitacin E (CuE), like other cucurbitacins, is a potential anti-neoplastic agent. The aim of the present study was to investigate the in vitro effects of CuE on phytohaemagglutinin (PHA)-activated and unstimulated lymphocytes. CuE did not produce any significant cytotoxic effects on the two models. On the contrary, it had a stimulatory effect, and was capable of inducing and maintaining high proliferation rates in lymphocytes. The stimulatory effect of CuE was concentration-dependent with a median stimulatory concentration (SC 50 ) of 1.166 mM and reaching maximal effect at a concentration of 10-20 mM. The stimulatory effect of CuE was about 25% lower than that of PHA, but a combination of CuE and PHA had an additive effect producing a greater response than that induced by the two substances used separately. Agarose gel electrophoresis for DNA fragmentation failed to show any significant apoptotic activity in the cells after 48 h exposure to CuE.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effects of Cucurbitacin E on Two Lymphocyte Models

Attard

Cuschieri

Scicluna-Spiteri

et al. 2004

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…However, in our previous investigation using four different animal species models [27], we reported, that EE juice resulted a significant marked decrease in bilirubin presented in the serum in a dose related manor. Therefore, the exact mechanism(s) of the juice has to be clarified in future researches.…”

Section: Discussionmentioning

confidence: 77%

Human Exposure to <i>Ecballium elaterium</i> Fruit Juice: Fatal Toxicity and Possible Remedy

Salhab¹

2013

View full text Add to dashboard Cite

The human serious adverse reactions of the folkloric plant, Ecballium elaterium (EE), are well documented in the literature. This report is presenting the medical literature of 74 cases, which experienced severe adverse reactions or deaths that resulted from the administration of the plant juice. The survey of these human cases exhibits several adverse effects such as: acute rhinitis, uvular edema, soft palate, upper airway edema. In conclusion, the use of EE juice in folk medicine can cause severe adverse reactions that should not be ignored but it should be medically treated.

show abstract

“…Elayan et al (1989) have shown that the administration of Ecballium elaterium juice to male rats with surgically induced jaundice produced a decrease in serum bilirubin concentration. However the mechanism by which the juice affects this parameter was unclear.…”

Section: Discussionmentioning

confidence: 98%