Effects ofBangkibokryeong-tang(Fangjifuling-tang) on the Reduction of Blood Glucose and Body Fat in High Fat Diet Induced Obese Mice

Abstract

Objectives This study aimed to investigate the effect of Bangkibokryeong-tang (BBT, Fangjifuling-tang) on blood glucose and body fat in high-fat diet-induced obese mice.Methods The experimental animals were divided into five groups-normal diet-fed control (ND), high-fat diet-fed control (HFD), HFD+BBT 75, HFD+BBT 150, and HFD+olistat as a positive drug control group. Markers of obesity, such as body weight, organ weight, diet efficiency, and serum levels of total cholesterol, triglycerides, lipid content, leptin, adiponectin, glutamic oxaloacetic transaminase (GOT)/glutamic pyruvic transferase (GPT)/lactate dehydrogenase (LDH), blood glucose, and insulin, were measured. Furthermore, results of the oral glucose tolerance test and α-glucosidase inhibition activity were examined in obese mice. Results Mice treated with BBT demonstrate lower body and organ weight, and reduced weight gain and food efficiency than that in the HFD-only control group. In addition, BBT decreased lipid accumulation in the liver and the levels of enzymes such as GOT, GPT, and LDH in the serum. Furthermore, the levels of triglycerides, total cholesterol, low density lipoprotein (LDL), and leptin were decreased in the serum but the levels of high density lipoprotein (HDL) and adiponectin were increased in the BBT-treated group compared with the control group. The BBT-treated group also demonstrated decreased blood glucose and insulin concentrations induced by feeding on a high-fat diet and improved glucose tolerance. Conclusions Based on the results above, BBT may reduce body fat and hyperglycemia in HFD-induced obesity. This suggests that BBT may be clinically useful in the treatment of obesity. (J Korean Med Rehabil 2017;27(1):1-17)

Research Trends of Animal Experiment on the Herbal Medicine for Obesity: During the Recent 5 Years

“…각 연구에서는 실험동물을 2~6군으로 나누어 군별로 다른 중재를 적용하였다. 선정된 논문 중 3편 15,28,37) 을 제외한 대 부분의 논문에서 비만을 유발하지 않은 정상 대조군을 설정 하였고, 27편 11,[16][17][18]23,24,27,[29][30][31]33,34,37,38,[40][41][42]44,45,48,51,52,[55][56][57][58][59] 에서 양성 대조군을 설정하였다. 또한 실험군에서 2~3군별로 용량을 다르 게 투여해 비교한 논문이 34편 14,[16][17][18][19][20][21][22][23][25][26][27][30][31][32][33][34][35]37,38,41,42,…”

“…복합처방은 모두 25가지가 사용되었고, 강지환 21,28) , 백출과 사인 혼합물 43,52) 하였다. 양성 대조군에는 Orlistat이 9편 23,24,30,31,41,42,45,55,57) 에서 사용되어 가장 많았고, metformin [16][17][18]27,51,58) 과 garcinia cambogia 29,33,34,40,53,56) 가 각각 6편, 마황 37.55) 과 simvastatin 38,48) 이 각각 2편에서 사용되었다. 그 외 milk thistle 11) .…”

“…중재기간은 짧게는 2주 13) 에서 길게는 16주 22) 까지였으 며, 동일한 중재에 대해 6, 8, 16주씩 기간을 다르게 설정 하여 비교한 논문이 1편 50) 있었다(Tables 1, 2). 26,30,32,39,60) , 3가지 범주의 평가방법을 사용한 논문이 20 11,12,14,18,[20][21][22][23]28,31,33,37,[43][44][45]51,52,54,58,59) 이었고, 4가지 범주의 평가방 법을 모두 사용한 논문이 24편 13,[15][16][17]19,24,25,27,29,35,36,38,[40][41][42][46][47][48][49][50]53,[55][56][57] 으로 가장 많았다. 13,15,…”

“…현미경적 분석은 35편 11,[13][14][15][16][17][18][19][20][21][22][23][24][25]27,29,33,35,36,38,[40][41][42][46][47][48][49][50][51][53][54][55][56][57][58] 에서 이루 어졌고, 간조직, 지방조직, 골격근조직, 췌장조직 등을 대 상으로 하였다. 31편 11,13,[15][16][17][18][19][20][21][22][23][24]27,29,33,35,36,38,…”