Effects of Hypoxia during Continuous and Intermittent Exercise on Glycaemic Control and Selected Markers of Vascular Function in Type 1 Diabetes

Hall, Barbara; Żebrowska, Aleksandra; Kamiński, Tomasz; Stanula, Arkadiusz; Robins, Anna

doi:10.1055/s-0043-110482

Cited by 8 publications

(11 citation statements)

References 68 publications

(117 reference statements)

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“…We also found similar increase in VD and %EF, 30 minutes and 24 hours after the sessions. Our results corroborate the findings of Hall et al 36 , in which an intermittent aerobic session can cause a vessel size relaxation over 100%. Physiologically, intermittent periods in a session with higher-intensity bouts could lead to an adrenalin release and improvements in vascular system reactivity in TD1M after exercise because of the vascular endothelial growth factor enhancement 36 .…”

Section: Comparison Between Avg and Runningsupporting

confidence: 93%

Cardiovascular and Enjoyment Comparisons after Active Videogame and Running in Type-1 Diabetics: A Randomized Crossover Trial

Gomes

Vancea

Araújo

et al. 2021

Games for Health Journal

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Comparison Between Avg and Runningsupporting

confidence: 93%

Cardiovascular and Enjoyment Comparisons after Active Videogame and Running in Type-1 Diabetics: A Randomized Crossover Trial

Gomes

Vancea

Araújo

et al. 2021

Games for Health Journal

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show abstract

“…They also include arachidonic acid, and other unsaturated non‐esterified fatty acids which influence β‐cell proliferation (Dixon, Nolan, McClenaghan, Flatt, & Newsholme, 2004). Vascular endothelial growth factor‐A (VEGF‐A), a growth factor imperative for the formation of β‐cell structure (Watada, 2010), also appears to increase following exercise in humans (Hall, Zebrowska, Kaminski, Stanula, & Robins, 2018).…”

Section: Effect Of Exercise On β‐Cell Massmentioning

confidence: 99%

The benefits of physical exercise for the health of the pancreatic β‐cell: a review of the evidence

Curran

Drayson

Zoppi

et al. 2020

Experimental Physiology

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Physical exercise is a core therapy for type 1 and type 2 diabetes. Whilst the benefits of exercise for different physiological systems are recognised, the effect of exercise specifically on the pancreatic -cell is not well described. Here we review the effects of physical exercise on -cell health.We show that exercise improves -cell mass and function. The improved function manifests primarily through the increased insulin content of the -cell and its increased ability to secrete insulin in response to a glucose stimulus. We review the evidence relating to glucose sensing, insulin signalling, -cell proliferation and -cell apoptosis in humans and animal models with acute exercise and following exercise training programmes. Some of the mechanisms through which these benefits manifest are discussed. K E Y W O R D S

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“…Furthermore, Brinkmann et al (2017) showed significant increases in the VEGF, induced by 40 minutes of cycling at sub-maximal intensities with intermittent periods of hypoxia and hyperoxia in Type 2 diabetic patients. In this study, however, it is likely that the observed changes in the VEGF were induced by hypoxia rather than hyperoxia, as was previously shown in patients with Type 1 diabetes (Hall et al, 2018).…”

Section: Introductionmentioning

confidence: 49%

“…This is because at least in rodents it was previously shown that cerebral VEGF release was triggered by activation of the lactate receptor HCAR1 ( Morland et al, 2017 ). Interestingly, in Type 2 diabetic patients a significantly larger increase in VEGF concentrations was observed already after sub-maximal endurance cycling when subjects were breathing intermittent hypoxic (14% O 2 ) and hyperoxic (30% O 2 ) air as compared to normoxic conditions ( Brinkmann et al, 2017 ), but it is likely that this was induced by hypoxia rather than hyperoxia ( Hall et al, 2018 ). Future research therefore needs to address our observed anomaly and discern whether our findings are real or an artifact.…”

Section: Discussionmentioning

confidence: 99%

Acute Hormonal Responses to High-Intensity Interval Training in Hyperoxia

Manferdelli

Freitag

Doma

et al. 2020

Journal of Human Kinetics

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This study aimed to compare selected hormonal responses to a single session of high intensity interval training performed with an increased fraction of inspired oxygen (hyperoxia) and under normoxic conditions. Twelve recreationally trained men (age 24 ± 3 years) performed two sessions of high intensity interval training on a cycle ergometer, in randomized order with hyperoxia (4 L·min-1 with a flowrate of 94% O2) and normoxia. Each session consisted of 5 intervals of 3 minutes at 85% of the maximal power output, interspersed by 2 min at 40% of the maximal power output. Serum cortisol, prolactin and vascular endothelial growth factor (VEGF) were assessed both before and immediately after each high intensity interval training session. Statistically significant differences in cortisol were found between hyperoxic and normoxic conditions (p = 0.011), with a significant increase in hyperoxia (61.4 ± 73.2%, p = 0.013, ES = -1.03), but not in normoxia (-1.3 ± 33.5%, p > 0.05, ES = 0.1). Prolactin increased similarly in both hyperoxia (118.1 ± 145.1%, p = 0.019, ES = -0.99) and normoxia (62.14 ± 75.43%, p = 0.005, ES = -0.5). VEGF was not statistically altered in either of the conditions. Our findings indicate that a single session of high intensity interval training in low-dose hyperoxia significantly increased cortisol concentrations in recreationally trained individuals compared to normoxia, while the difference was smaller in prolactin and diminished in VEGF concentrations.

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Effects of Hypoxia during Continuous and Intermittent Exercise on Glycaemic Control and Selected Markers of Vascular Function in Type 1 Diabetes

Abstract: Combining exercise with hypoxia may allow more effective short-term glycaemic control in T1D. Intermittent exercise with hypoxia could stabilize the secretion of selected proangiogenic factors and reduce inflammation, potentially leading to improved vascular function.

Cited by 8 publications

References 68 publications

Cardiovascular and Enjoyment Comparisons after Active Videogame and Running in Type-1 Diabetics: A Randomized Crossover Trial

Cardiovascular and Enjoyment Comparisons after Active Videogame and Running in Type-1 Diabetics: A Randomized Crossover Trial

The benefits of physical exercise for the health of the pancreatic β‐cell: a review of the evidence

Acute Hormonal Responses to High-Intensity Interval Training in Hyperoxia

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