Effects of hypothermia and hypoxia on cytochrome P450‐mediated drug metabolism in neonatal Göttingen minipigs
Marina‐Stefania Stroe,
Laura De Clerck,
Maarten Dhaenens
et al.
Abstract:Asphyxiated neonates often undergo therapeutic hypothermia (TH) to reduce morbidity and mortality. As perinatal asphyxia and TH impact neonatal physiology, this could also influence enzyme functionality. Therefore, this study aimed to unravel the impact of age, hypothermia and hypoxia on porcine hepatic cytochrome P450 (CYP) gene expression, protein abundance and activity. Hepatic CYP expression, protein abundance and activity were assessed in naive adult and neonatal Göttingen minipigs, alongside those from a… Show more
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