Effects of hypertonic versus isotonic infusion therapy on regional cerebral blood flow after experimental cardiac arrest cardiopulmonary resuscitation in pigs

Hemodynamic, respiratory, and perfusion parameters during asphyxia, resuscitation, and post-resuscitation in a pediatric model of cardiac arrest

“…Several studies had indicated that after ROSC there is a sepsis-like syndrome with relative decrease of intravascular volume [25][26][27]. Our results support those findings and suggest that some fluid challenge could be needed after ROSC, even in the case of hypoxic CA and despite normal CI, MAP, and SVV data.…”

Part 8: Adult Advanced Cardiovascular Life Support

“…Most human and animal studies of fluid infusion during CPR did not have a control group, [332][333][334][335][336][337][338][339][340][341][342][343] and 2 animal studies showed that normothermic fluid infusion during CPR caused a decrease in CPP. 344 -346 In addition to normothermic fluid, hypertonic and chilled fluids have been studied in animal and small human studies without a survival benefit.…”

Post–Cardiac Arrest Syndrome

“…No evidence is available to indicate an advantage for any specific type of fluid (crystalloid or colloid) in the post-cardiac arrest phase. Some animal data are available indicating that hypertonic saline may improve myocardial and cerebral blood flow when given during CPR, 137,138 but no clinical data indicate an advantage for hypertonic saline in the post-cardiac arrest phase. The balance between systemic oxygen delivery and consumption can be monitored indirectly with mixed venous oxygen saturation (SvO 2 ) or ScvO 2 .…”