Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis

Bleul, Ulrich; Schwantag, S.; Kähn, W.

doi:10.2460/javma.231.4.576

Cited by 2 publications

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“…As the bone glue contained 9.6% sodium hydrogen carbonate for pore formation, it can be hypothesized that solubilization of sodium hydrogen carbonate resulted in a transient complex formation with calcium ions in the blood plasma. In calves, a decrease in total calcium plasma concentration was observed after administration of hypertonic sodium bicarbonate solution46 and a similar effect was demonstrated in people 47. Generally, calcium plasma concentration in rabbits is depending on the amount of calcium in the food42; however, the rabbits reported here were always fed with the same commercial pellets.…”

Section: Discussionsupporting

confidence: 74%

Biodegradable β‐Tri‐Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model

et al. 2009

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Bone gluing is an attractive surgical technique; however, its use in patients is hampered by a variety of side effects. Therefore, it was the aim of this ethically approved study to evaluate a novel biodegradable beta-Tri-Calciumphosphate (beta-TCP, Cerasorb)-enhanced bone adhesive regarding its toxicity and biocompatibility in a rabbit model. Fifty healthy New Zealand White rabbits were assigned in the study (n = 21) and sham-operated control group (n = 29). In the study group, a cylindrical part (4.6 x 10.0 mm) of the proximal tibia and distal femur was removed, reimplanted, and bone adhesive was applied. Blinded physical examination and sampling for hematology, clinical chemistry, and acute phase proteins (haptoglobin, C-reactive protein (CRP)) was performed before surgery and after 12, 24, 48, 72, 240, and 504 h. Significant findings of the physical examination included a slightly higher grading of warmth (p = 0.0019) and pain (p < 0.0001) of the wound 240 h after surgery in the study group. No significant differences between albumin, haptoglobin, CRP, and urea concentrations in both groups were evident, whereas the study group demonstrated significantly lower leukocyte count, total protein, and globulin concentrations (p < 0.0001). As expected, both groups showed a marked transient increase in muscle enzymes (Creatine Kinase and Aspartate Aminotransferase) following the surgery (p < 0.0001). Twelve to 24 h after surgery, a significant decrease in ionized calcium from 1.38 +/- 0.12 mmol/L to 1.06 +/- 0.13 mmol/L was noted in the study group (p < 0.0001). The results clearly indicated that the novel beta-TCP-enhanced bone adhesive showed good biocompatibility without significant evidence of acute or subacute local or systemic toxicity.

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Section: Discussionsupporting

confidence: 74%

Biodegradable β‐Tri‐Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model

et al. 2009

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“…There have been a series of studies documenting respiratory acidosis in neonatal calves both experimentally and in naturally occurring cases of dystocia, and severity of acidosis has been correlated with nonsurvival and reduced absorption of colostral IgG . While these calves could have experienced a hypoxic cerebral injury, there has been little description of the clinical signs, treatment, and survival of such calves in the neonatal period beyond immediate resuscitation and survival.…”

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confidence: 99%

Neonatal Encephalopathy in Calves Presented to a University Hospital

Bianco

Moore

Taylor

2017

Veterinary Internal Medicne

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BackgroundWhile studies have examined bovine dystocia in relation to calf survival, little has been published regarding perinatal morbidity and treatment of newborn calves beyond failure of transfer of passive immunity (FTPI). Neonatal encephalopathy (NE) is a clinical syndrome commonly diagnosed in infants and foals but is poorly described in calves.Hypothesis/ObjectivesTo identify risk factors for development of NE in calves and factors predictive of survival.AnimalsNeonatal calves presented to a University hospital over a 10‐year period.MethodsRetrospective cohort study (2005–2015). Medical records of all neonatal calves presented to the hospital were examined, and cases of NE were identified. Data pertaining to demographics, dam parity, labor, treatment, and outcome were collected and analyzed with univariate and multivariate statistics.ResultsOf 200 calves in the final analysis, 58 (29%; 95% CI: 22.8–35.8%) were classified as NE and 142 calves as non‐NE. In univariate analysis, factors significantly associated with diagnosis of NE included male sex, presence of dystocia, abnormal position in the birth canal, and prolonged labor. In the multivariate model, only orientation of the calf in the birth canal remained significant (OR 2.14; 95% CI: 1.02–4.49; P = 0.044). Overall survival of calves with NE was good (45/58; 77.6%; 95% CI: 64.7–87.5); dam parity and being a twin was significantly associated with nonsurvival.ConclusionsCalves born after dystocia, especially if malpresented, should be closely monitored for nursing behavior within the first 24 hours of life. Prognosis for survival is good, but supportive care might be required for several days.

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Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis

Cited by 2 publications

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Biodegradable β‐Tri‐Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model

Biodegradable β‐Tri‐Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model

Neonatal Encephalopathy in Calves Presented to a University Hospital

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