Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis

Bleul, Ulrich; Schwantag, S.; Kähn, W.

doi:10.2460/ajvr.68.8.850

Cited by 14 publications

(13 citation statements)

References 20 publications

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“…Being neonates, hypoglycemia may contribute to bradycardia when this sign is present. Buffer solutions containing sodium bicarbonate have safely been used recently to improve the acid-base status in acidotic perinatal calves (23). One way to treat metabolic acidosis and hyperkalemia is by IV infusions of 5% dextrose solution containing 150 mEq NaHCO 3 /L.…”

Section: Resultsmentioning

confidence: 99%

Terminal atrial standstill with ventricular escape rhythm in a neonatal calf with acute diarrhea

Basoglu

Aydoğdu²

2013

Turk J Vet Anim Sci

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Section: Resultsmentioning

confidence: 99%

Terminal atrial standstill with ventricular escape rhythm in a neonatal calf with acute diarrhea

Basoglu

Aydoğdu²

2013

Turk J Vet Anim Sci

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“…These results have already been envisaged in previous studies that decrease in plasma volume stimulates sympathetic nervous system which increases the heart rate through peripheral vasoconstriction. It also stimulates rennin-angiotensin-aldosterone system to maintain mean arterial pressure, heart balance and organ perfusion (Flores et al, 2006;Bleul et al, 2007). In calves with diarrhea, heart rate decreased toward baseline after administration of ISS and HSS to groups A and B, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In calves with diarrhea, heart rate decreased toward baseline after administration of ISS and HSS to groups A and B, respectively. An immediate expansion in plasma volume due to increased serum osmolarity is the contributing factor for activation of cardiovascular reflex mechanisms (Bertone et al, 1990;Constable et al, 1995;Bleul et al, 2007). These effects were, however, transient; lasting only for one h and then heart rate dropped and became normal rapidly.…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous administration of HSS causes an initial rapid influx of fluid into the vasculature due to the sudden hypertonic state of plasma in a relatively short time (Constable et al, 1991a;Walker et al, 1998;Bleul et al, 2007;Leal et al, 2012). Plasma volume expansion is, therefore, achieved with lesser free water administration than with isotonic solutions.…”

Section: Introductionmentioning

confidence: 99%

“…Plasma volume expansion is, therefore, achieved with lesser free water administration than with isotonic solutions. Since administration of a hypertonic should lead to recruitment of extravascular fluids into the vascular compartment, HSS seems likely to produce a more rapid response and marked hemodynamic effects than isotonic solutions (Bleul et al, 2007;Leal et al, 2012) with a small-volume @ 4 mL/kg BW.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Relative Resuscitative Effects of Hypertonic and Isotonic Saline Solutions as an Adjunct to Ceftiofur HCl in Bovine Neonatal Diarrhea Associated with Escherichia coli

Zafar¹,

Muhammad²,

Iqbal³

et al. 2015

IJAB

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To cite this paper: Zafar, M.A., G. AbstractThis study was conducted for evaluation of relative efficacy of hypertonic saline (HSS) and isotonic saline (ISS) solutions in neonatal diarrhea associated with Escherichia coli (E. coli) in buffalo calves. For this purpose, neonatal diarrhea was induced in 24 healthy male buffalo calves through oral administration of eneteropathogenic E. coli (K99). After 12 h of successful induction of diarrhea, the calves were randomly divided into two equal groups viz. A and B (n=12 each). Group A was treated with ISS @ 90 mL/kg body weight (BW), while calves of group B were administered HSS @ 4 mL/kg BW. Both groups were additionally treated with ceftiofur HCl and flunixin meglumine @ 6 and 2 mg/kg BW, IM, respectively. The relative efficacy of two treatments was evaluated on the basis of clinical parameters, hematological analyses, hemodynamic parameters, blood gas analyses and serum electrolytes. All parameters were recorded at baseline (before induction of diarrhea), during diarrhea, t=1, t=3, t=6, t=12, t=24 and t=36 h after treatment. The calves treated with HSS (group B) resuscitated from neonatal diarrhea more rapidly (within 24 h) and effectively than ISS (group A) and showed significant (P < 0.05) improvement. At t=24 h, values for mean arterial pressure, central venous pressure and arterial oxygen delivery were 108.6±9.8 and 116.3±14.2, 12±1.4 and 15.5±1.5 and 69.3±3.3 and 85.5±3.7 in groups A and B, respectively. Calves of group B also experienced decrease in hematocrit and hemoglobin concentration as well as increases in blood pH, bicarbonate concentration and serum electrolytes. On the basis of findings of this study, it was concluded that HSS offsets deleterious hemodynamic effects of hypovolemia, improves oxygenation, corrects metabolic acidosis and increases survival in E. coli associated neonatal diarrhea of buffalo calves which makes it more practical and economical alternative to the use of large volumes of isotonic saline solution for use in field settings.

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Biodegradable β‐Tri‐Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model

et al. 2009

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Bone gluing is an attractive surgical technique; however, its use in patients is hampered by a variety of side effects. Therefore, it was the aim of this ethically approved study to evaluate a novel biodegradable beta-Tri-Calciumphosphate (beta-TCP, Cerasorb)-enhanced bone adhesive regarding its toxicity and biocompatibility in a rabbit model. Fifty healthy New Zealand White rabbits were assigned in the study (n = 21) and sham-operated control group (n = 29). In the study group, a cylindrical part (4.6 x 10.0 mm) of the proximal tibia and distal femur was removed, reimplanted, and bone adhesive was applied. Blinded physical examination and sampling for hematology, clinical chemistry, and acute phase proteins (haptoglobin, C-reactive protein (CRP)) was performed before surgery and after 12, 24, 48, 72, 240, and 504 h. Significant findings of the physical examination included a slightly higher grading of warmth (p = 0.0019) and pain (p < 0.0001) of the wound 240 h after surgery in the study group. No significant differences between albumin, haptoglobin, CRP, and urea concentrations in both groups were evident, whereas the study group demonstrated significantly lower leukocyte count, total protein, and globulin concentrations (p < 0.0001). As expected, both groups showed a marked transient increase in muscle enzymes (Creatine Kinase and Aspartate Aminotransferase) following the surgery (p < 0.0001). Twelve to 24 h after surgery, a significant decrease in ionized calcium from 1.38 +/- 0.12 mmol/L to 1.06 +/- 0.13 mmol/L was noted in the study group (p < 0.0001). The results clearly indicated that the novel beta-TCP-enhanced bone adhesive showed good biocompatibility without significant evidence of acute or subacute local or systemic toxicity.

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Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis

Cited by 14 publications

References 20 publications

Terminal atrial standstill with ventricular escape rhythm in a neonatal calf with acute diarrhea

Terminal atrial standstill with ventricular escape rhythm in a neonatal calf with acute diarrhea

Evaluation of Relative Resuscitative Effects of Hypertonic and Isotonic Saline Solutions as an Adjunct to Ceftiofur HCl in Bovine Neonatal Diarrhea Associated with Escherichia coli

Biodegradable β‐Tri‐Calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model

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