Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial

Naumann, Johannes; Grebe, Julian; Kaifel, Sonja; Weinert, Tomas; Sadaghiani, Catharina; Huber, Roman

doi:10.1186/s12906-017-1676-5

Cited by 42 publications

(37 citation statements)

References 37 publications

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“…[33] This pilot study suggests that hyperthermic baths do have generalized efficacy in depressed patients. In another study the spa therapy shows a potential approach for breast cancer rehabilitation.…”

Section: Known As Balneotherapymentioning

confidence: 85%

Integration of Unani Medicine in Cancer Management

Naaz¹

2017

WJPR

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Unani medicine is the traditional art of healing recognized worldwide.Unani medicine has got answers to every disease and ailment which makes it parallel to modern medicine in providing healthcare services to mankind. Cancer is one of the fastest growing diseases, with an estimated worldwide incidence of 10 million new cases per year. The goal of cancer treatment is first to eradicate the cancer. If this primary goal cannot be accomplished, the therapeutic goal shifts to palliation, the amelioration of symptoms, and preservation of the patient's quality of life (QOL). Current conventional anticancer therapies are associated with adverse effects, drug resistance, and cancer recurrence. Therefore, there is still an urgent need for new therapeutic options for cancer.Current evidence, based on modern studies suggests that Unani system of medicine may provide alternative means to cancer treatment. This review offers an evidence-based perspective of integration of Unani medicine in cancer management. An effort has been made to understand the role Unani medicine can play in cancer management as adjuvant therapy as well as a substitute to conventional chemotherapeutic agents.

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Section: Known As Balneotherapymentioning

confidence: 85%

Integration of Unani Medicine in Cancer Management

Naaz¹

2017

WJPR

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“…Fever, respectively hyperthermia, has been used as a medical treatment since ancient times, and beneficial effects of fever on mental illness were already described in antiquity (10). Based on recent findings, there is growing scientific evidence that hyperthermic baths (HTB) and whole body hyperthermia (WBH) might be efficacious for treatment of depressive disorders (11)(12)(13)(14). The results of a non-controlled HTB study with 20 depressive patients showed an improvement in the 21-item Hamilton Depression Rating Scale (15) after five baths (11).…”

Section: Introductionmentioning

confidence: 99%

Effects and Feasibility of Hyperthermic Baths for Patients with Depressive Disorder: A Randomized Controlled Clinical Pilot Trial

Naumann

Sadaghiani

Kruza

et al. 2018

Preprint

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Background: Evaluation of efficacy, safety and feasibility of hyperthermic baths (HTB;head-out-of-water-immersion in 40°C), twice a week, compared to a physical exercise program (PEP; moderate intensity aerobic exercises) in moderate to severe depression. Method: Single-site, open-label randomized controlled 8-week parallel-group pilot study at an university outpatient clinic as part of usual depression care. Medically stable outpatients with depressive disorder (ICD-10: F32/F33) as determined by the 17-item Hamilton Depression Rating Scale (HAM-D) score ≥18 and a score ≥2 on item 1 (Depressed Mood) were randomly assigned to receive either two sessions of HTB or PEP per week (40-45 min) provided by two trained doctoral students. An independent biometric center used computer-generated tables to allocate treatments. Primary outcome measure was the change in HAM-D total score from baseline (T0) to the 2week time point (T1). Linear regression analyses, adjusted for baseline values, were performed to estimate intervention effects on an intention-to-treat (ITT) principle.Findings: 45 patients (HTB n = 22; PEP n = 23) were randomized and analyzed according to ITT (mean age = 48.4 years, SD = 11.3, mean HAM-D score = 21.7, SD = 3.2). Baseline-adjusted mean difference was 4.3 points in the HAM-D score in favor of HTB (p<0.001). This improvement was achieved after two weeks. Compliance with the intervention and follow-up was far better in the HTB group (2 vs 13 dropouts). There were no treatment-related serious adverse events. Main limitation: the number of dropouts in the PEP group (13 of 23) was far higher than in other trials investigating exercise in depression (18.1 % dropouts).Conclusions: HTB seems to be a fast-acting, safe and easy accessible method leading to clinically relevant improvement in depressive disorder after two weeks; it is also suitable for persons who have problems performing exercise training. Trial registration: German Clinical Trials Register (DRKS) with the registration number DRKS00011013 (registration date 2016-09-19) before onset of the study.

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“…Coordination among different specific treatment registries that already exist (e.g., the vagal nerve stimulation registry that the FDA requires(Aaronson et al, 2017;Naumann et al, 2017) and the transcranial magnetic stimulation registry recently launched by Neurostar (NeuroStar Advanced Therapy, 2017) and that have been suggested (e.g., a ketamine registry; Singh, Singh, Kar, & Pahuja, 2017) would be a necessary step. Documenting all steps in such investigations, reporting on all planned outcomes, and otherwise ensuring complete transparency for this study are critical actions in adding to the professional literature.…”

mentioning

confidence: 99%

“…For instance, a treatment registry using common data elements could substantially help clarify the criteria that best define TRD, what the course of illness is, and how interventions might affect that course. Coordination among different specific treatment registries that already exist (e.g., the vagal nerve stimulation registry that the FDA requires(Aaronson et al, 2017;Naumann et al, 2017) and the transcranial magnetic stimulation registry recently launched by Neurostar (NeuroStar Advanced Therapy, 2017) and that have been suggested (e.g., a ketamine registry;Singh, Singh, Kar, & Pahuja, 2017) would be a necessary step. Data quality is a key challenge for such an enterprise.…”

mentioning

confidence: 99%

Defining treatment‐resistant depression

et al. 2019

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Background: Varying conceptualizations of treatment-resistant depression (TRD) have made translating research findings or systematic reviews into clinical practice guidelines challenging and inconsistent. Methods: We conducted a review for the Centers for Medicare & Medicaid Services and the Agency for Healthcare Research and Quality to clarify how experts and investigators have defined TRD and to review systematically how well this definition comports with TRD definitions in clinical trials through July 5, 2019. Results: We found that no consensus definition existed for TRD. The most common TRD definition for major depressive disorder required a minimum of two prior treatment failures and confirmation of prior adequate dose and duration. The most common TRD definition for bipolar disorder required one prior treatment failure. No clear consensus emerged on defining adequacy of either dose or duration. Our systematic review found that only 17% of intervention studies enrolled samples meeting the most frequently specified criteria for TRD. Depressive outcomes and clinical global impressions were commonly measured; functional impairment and quality-of-life tools were rarely used. Conclusions:Two key steps are critical to advancing TRD research: (a) Developing a consensus definition of TRD that addresses how best to specify the number of prior treatment failures and the adequacy of dose and duration; and (b) identifying a core package of outcome measures that can be applied in a standardized manner. Our recommendations about stronger approaches to designing and conducting TRD research will foster better evidence to translate into clearer guidelines for treating patients with this serious condition.

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Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial

Cited by 42 publications

References 37 publications

Integration of Unani Medicine in Cancer Management

Integration of Unani Medicine in Cancer Management

Effects and Feasibility of Hyperthermic Baths for Patients with Depressive Disorder: A Randomized Controlled Clinical Pilot Trial

Defining treatment‐resistant depression

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