Effects of Hyperthermia on Intracranial Pressure and Cerebral Autoregulation in Patients with an Acute Brain Injury

Ошоров, А В; Баранич, А И; Полупан, А. А.; Сычев, А А; Савин, И А; Потапов, А. А.

doi:10.1007/978-3-030-59436-7_15

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“…This suggests that hyperthermia exerts an inhibitory impact on the glymphatic influx. The ICP was elevated in hyperthermia animals, 33 potentially leading to a decrease in the influx of nanoprobe into the cranial cavity. We performed a 1 mm diameter craniotomy on one mouse in the Hyper Iso/Dex group to alleviate ICP (Figure 4j).…”

Section: Resultsmentioning

confidence: 99%

Near-Infrared-II Imaging Revealed Hypothermia Regulates Neuroinflammation Following Brain Injury by Increasing the Glymphatic Influx

Li,

Sun,

Zhang

et al. 2024

ACS Nano

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Advanced in vivo imaging techniques have facilitated the comprehensive visual exploration of animal biological processes, leading to groundbreaking discoveries such as the glymphatic system. However, current limitations of macroscopic imaging techniques impede the precise investigation of physiological parameters regulating this specialized lymphatic transport system. While NIR-II fluorescence imaging has demonstrated advantages in peripheral lymphatic imaging, there are few reports regarding its utilization in the glymphatic system. To address this, a noninvasive transcranial macroscopic NIR-II fluorescence imaging model is developed using a cyanine dye-protein coupled nanoprobe. NIR-II imaging with high temporal and spatial resolution reveals that hypothermia can increase the glymphatic influx by reducing the flow rate of cerebrospinal fluid. In addition, respiratory rate, respiratory amplitude, and heart rate all play a role in regulating the glymphatic influx. Thus, targeting the glymphatic influx may alter the trajectory of immune inflammation following brain injury, providing therapeutic prospects for treating brain injury with mild hypothermia.

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Section: Resultsmentioning

confidence: 99%