Effects of Hyperthermia on Bladder Cancer

Rr, Hall; Schade, R. O. K.; Swinney, John

doi:10.1136/bmj.2.5919.593

Cited by 85 publications

(19 citation statements)

References 11 publications

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“…4 C at k eff ¼ 10 W=K=m and 43. 6 C at k eff ¼ 50 W=K=m or above. Spatial temperature distribution along the anteriorposterior, inferior-superior, and left-right directions across the bladder are plotted in Fig.…”

Section: Iiia Determination Of K Effmentioning

confidence: 99%

“…2,4 The rationale behind this could be the increased rate of drug uptake due to increased permeability of the tumor cell membrane with heating. 5 Therapeutic heating of the anticancer agent can be accomplished by intracavitary irrigation with warmed saline (43-45 C) 6 or by delivering a properly focused power deposition pattern using ultrasound 7 or electromagnetic (EM) waves, which penetrates heat further into and around the bladder wall than heated saline irrigation. 1,5,8 Treatment planning based on both specific absorption rate (SAR) and temperature-based optimization has been used to provide better targeted heating in various sites.…”

Section: Introductionmentioning

confidence: 99%

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Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma

et al. 2012

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Purpose: A recently completed Phase I clinical trial combined concurrent Mitomycin-C chemotherapy with deep regional heating using BSD-2000 Sigma-Ellipse applicator (BSD Corporation, Salt Lake City, UT, U.S.A.) for the treatment of nonmuscle invasive bladder cancer. This work presents a new treatment planning approach, and demonstrates potential impact of this approach on improvement of treatment quality. Methods: This study retrospectively analyzes a subset of five patients on the trial. For each treatment, expert operators selected "clinical-optimal" settings based on simple model calculation on the BSD-2000 control console. Computed tomography (CT) scans acquired prior to treatment were segmented to create finite element patient models for retrospective simulations with SigmaHyperPlan (Dr. Sennewald Medizintechnik GmbH, Munchen, Germany). Since Sigma-HyperPlan does not account for the convective nature of heat transfer within a fluid filled bladder, an effective thermal conductivity for bladder was introduced. This effective thermal conductivity value was determined by comparing simulation results with clinical measurements of bladder and rectum temperatures. Regions of predicted high temperature in normal tissues were compared with patient complaints during treatment. Treatment results using "computed-optimal" settings from the planning system were compared with clinical results using clinical-optimal settings to evaluate potential of treatment improvement by reducing hot spot volume. Results: For all five patients, retrospective treatment planning indicated improved matches between simulated and measured bladder temperatures with increasing effective thermal conductivity. The differences were mostly within 1.3 C when using an effective thermal conductivity value above 10 W/K/m. Changes in effective bladder thermal conductivity affected surrounding normal tissues within a distance of $1.5 cm from the bladder wall. Rectal temperature differences between simulation and measurement were large due to sensitivity to the sampling locations in rectum. The predicted bladder T90 correlated well with single-point bladder temperature measurement. Hot spot locations predicted by the simulation agreed qualitatively with patient complaints during treatment. Furthermore, comparison between the temperature distributions with clinical and computedoptimal settings demonstrated that the computed-optimal settings resulted in substantially reduced hot spot volumes. Conclusions: Determination of an effective thermal conductivity value for fluid filled bladder was essential for matching simulation and treatment temperatures. Prospectively planning patients using the effective thermal conductivity determined in this work can potentially improve treatment efficacy (compared to manual operator adjustments) by potentially lower discomfort from reduced hot spots in normal tissue.

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Section: Iiia Determination Of K Effmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma

et al. 2012

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“…. Initial reports in the literature suggested that perfusion at temperatures up to 45°C were well tolerated by patients and caused no permanent bladder damage (Lunglmayr et al 1973, Hall et al 1974. This was surprising in view of the results of Moritz (1947) and the explanation may be that the whole bladder was not being exposed to the temperature stated.…”

Section: Discussionmentioning

confidence: 56%

Hyperthermic Irrigation of Bladder in Treatment of Transitional Cell Carcinoma: Its Effectiveness in Controlling Persistent Haematuria

1979

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“…Since synergism between many cytostatic drugs and local hyperthermia (HT) in tumor cell killing has been seen in both in vivo and in vitro tumor model sys tems [8][9][10][11], the idea of combining LHT with cytostatic agents was an exciting proposition in experimental on cology. From the beginning, STCCB seemed a suitable Since the investigation in 1974 by Hall et al [12], irrigation of the bladder using heated saline via a ure thral catheter has been almost exclusively employed to induce local bladder HT [13][14][15][16], Unfortunately this procedure has severe clinical limi tations with regard to the homogeneous and effective heating of the tumor, while sparing the normal structure. To overcome these limitations, and in order to devise a system which will efficiently heat the tissue directly, we developed a new system based on irradiating the bladder wall with microwaves (MWs).…”

Section: Introductionmentioning

confidence: 99%

Combined Intravesical Chemotherapy with Mitomycin C and Local Bladder Microwave-Induced Hyperthermia as a Preoperative Therapy for Superficial Bladder Tumors

Rigatti¹,

Lev

Colombo

1991

Eur Urol

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Effects of Hyperthermia on Bladder Cancer

Abstract: SummaryA study of the effect of bladder lavage with isotonic fluid at 450 C on proliferative transitional celi carcinoma has shown definite cancericidal changes. These early studies suggest that further investigation of hyperthermia on a larger scale would be worth while.

Cited by 85 publications

References 11 publications

Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma

Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma

Hyperthermic Irrigation of Bladder in Treatment of Transitional Cell Carcinoma: Its Effectiveness in Controlling Persistent Haematuria

Combined Intravesical Chemotherapy with Mitomycin C and Local Bladder Microwave-Induced Hyperthermia as a Preoperative Therapy for Superficial Bladder Tumors

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