Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction open-label study

Hanon, Olivier; Berrou, Jean-Pascal; Nègre‐Pagès, Laurence; Goch, Jan Henryk; Nádházi, Zoltán; Petrella, Robert J.; Sedefdjian, A.; Sévenier, F; Shlyakhto, Е. V.; Pathak, Atul

doi:10.1097/hjh.0b013e328301a280

Cited by 70 publications

(55 citation statements)

References 39 publications

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“…[16][17][18][19][20][21] In addition, as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and potassium sparing diuretics have an advantage in preventing CI, activation of the renin-angiotensin system or low potassium concentration has been suggested to be involved in CI through possible contributors to CI pathogenesis, including oxidative stress, inflammation, platelet aggregation and vasoconstriction. [22][23][24][25][26][27][28][29] Aldosterone, a crucial factor downstream of the renin-angiotensinaldosterone system, has also been shown to cause target organ damage independent of its effects on blood pressure and to be a potent cerebrovascular risk factor.…”

Section: Discussionmentioning

confidence: 99%

High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension

et al. 2010

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Cognitive impairment leading to dementia is associated with high prevalence of hypertension, decreased quality of life and poor prognosis. Aldosterone is known as a risk factor for cardiovascular and cerebrovascular diseases. In addition, mineral corticoid receptors are abundantly expressed in the hippocampus, which plays a pivotal role in cognitive function; however, it has not been determined whether plasma aldosterone level is associated with cognitive impairment in patients with hypertension. We enrolled 68 patients with essential hypertension and assessed their cardiovascular risk factors, including blood pressure, hyperlipidemia, diabetes mellitus, obesity, smoking, history of cerebral infarction, renal function, parameters of inflammation, oxidative stress and nitric oxide bioavailability, a parameter of cerebral blood flow and carotid plaque by ultrasound examination, plasma renin activity and plasma aldosterone concentration (PAC). The mini-mental state examination (MMSE) was used to evaluate cognitive function. The relevance of cardiovascular risk factors and MMSE score was statistically evaluated. Multiple regression analysis showed that age (Po0.01), PAC (Po0.01) and history of cerebral infarction (Po0.05) were inversely and independently associated with MMSE score. Mineral corticoid receptor antagonists, including spironolactone and eplerenone, increased MMSE score in seven patients with hypertension, but not in the controls. In conclusion, increased PAC is associated with impaired cognitive function and mineral corticoid receptor blockade may protect against not only cardiovascular mortality, but also cognitive impairment in patients with hypertension.

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Section: Discussionmentioning

confidence: 99%

High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension

et al. 2010

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“…Metformin may even enhance survival in older humans (Bannister et al 2014). Several of these agents also appear to delay cancers, cognitive decline, cardiac dysfunction, and other agerelated diseases and disabilities in several species, including humans (Chiasson et al 2002;Zeymer et al 2004;Basso et al 2005;Dykens et al 2005;Johnson et al 2005;Crandall et al 2006;Hanon et al 2008;Seibel et al 2008;Libby et al 2009;Anfossi et al 2010;Landman et al 2010;Li et al 2010;Tosca et al 2010;Davies et al 2011;Huang et al 2011;Lamanna et al 2011;Lee et al 2011;Liu et al 2011;Monami et al 2011;Pasternak et al 2011;Majumder et al 2012;Roumie et al 2012;Salani et al 2012;Tseng 2012;Anisimov and Bartke 2013;Goldfine et al 2013;Hong et al 2013;Karnevi et al 2013;Martin-Montalvo et al 2013;Quinn et al 2013;Whittington et al 2013;Kennedy and Pennypacker 2014;Mannick et al 2014;Richardson et al 2014). A pipeline of even more interventions is developing that seem to enhance life span in experimental animals.…”

Section: Are There Translatable Interventions?mentioning

confidence: 99%

Translating the Science of Aging into Therapeutic Interventions

Kirkland

2016

Cold Spring Harb Perspect Med

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“…Importantly, the early cognitive deficit of young hypertensive individuals can be reversed with an appropriate antihypertensive therapy, as suggested by previous findings. 24,[57][58][59] The association between high BP and anxiety is supported by a large number of case-control studies, which compared either psychological symptoms in hypertensive and control subjects, or BP in patients with a variety of psychiatric disorders and controls. 60 When examining anxiety disorder, Vetere et al 61 found a higher prevalence in hypertensive individuals compared with controls.…”

Section: Discussionmentioning

confidence: 95%

Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function

Kovács

Bajkó²,

Szekeres³

et al. 2014

Journal of the American Society of Hypertension

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Hypertension and dyslipidemia belong to the most prevalent modifiable risk factors for cerebrovascular and cardiovascular diseases. Hereby, we aimed to examine the combined effects of newly diagnosed hypertension and hyperlipidemia on the characteristics of the arterial wall and on cognitive function. We examined 72 hypertensive and 85 apparently healthy individuals. Based on serum lipid levels, four subgroups were created ranging from normotensive-normolipidemic to hypertensivehyperlipidemic subjects. Carotid intima-media thickness (IMT), arterial stiffness, and cognitive function were assessed. IMT of controls was the lowest, whereas that of patients with both risk factors the highest. Stiffness parameters increased when both risk factors were present, whereas subjects with only one risk factor exhibited intermediate values. Hypertensive patients performed worse when memory, attention, reaction time, and trait anxiety were assessed. Significant worsening of IMT, arterial stiffness, and sum of neuropsychological scores was observed along with increasing mean arterial pressure. Generally, hyperlipidemia combining with hypertension resulted in further worsening of all examined parameters. Subclinical changes of the vascular wall and cognitive performance are already present in recently diagnosed hypertensive patients. Combination of hyperlipidemia and hypertension results in more severe impairments, therefore, early and intensive treatment may be crucial to prevent further deterioration. J Am Soc Hypertens 2014;-(-):1-11.

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Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction open-label study

Abstract: The results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction are supportive of the proposition that antihypertensive therapy based on drugs that target the renin-angiotensin system is associated with preservation of cognitive function.

Cited by 70 publications

References 39 publications

High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension

High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension

Translating the Science of Aging into Therapeutic Interventions

Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function

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