1990
DOI: 10.1152/ajpregu.1990.258.2.r309
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Effects of hyperosmolality and diuretics on heat-induced limb vasodilation in baboons

Abstract: Dehydration attenuates the increase in limb skin blood flow elicited by environmental heating (EH). This study sought to determine which of the two primary effects of dehydration, increased body fluid osmolality or decreased body fluid volume, was primarily responsible for this cutaneous vasoconstrictor bias in baboons. Unanesthetized chronically instrumented baboons were exposed to EH while in euhydrated state, after 65-69 h of water deprivation (dehydration), after infusion of a small volume of hypertonic (2… Show more

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Cited by 10 publications
(11 citation statements)
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“…In baboons, the magnitude of the diuretic-induced attenuation of the increase in leg blood flow during heating was virtually identical to that produced by 64-68 h of dehydration ( Fig. 11.10) (199). Since reductions in plasma volume produced by diuretics and by dehydration were very similar in that study (199), reduced body fluid volume may be the sole mediator of the attenuated increase in SkBF in the heated baboon.…”
Section: )mentioning
confidence: 55%
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“…In baboons, the magnitude of the diuretic-induced attenuation of the increase in leg blood flow during heating was virtually identical to that produced by 64-68 h of dehydration ( Fig. 11.10) (199). Since reductions in plasma volume produced by diuretics and by dehydration were very similar in that study (199), reduced body fluid volume may be the sole mediator of the attenuated increase in SkBF in the heated baboon.…”
Section: )mentioning
confidence: 55%
“…11.10) (199). Since reductions in plasma volume produced by diuretics and by dehydration were very similar in that study (199), reduced body fluid volume may be the sole mediator of the attenuated increase in SkBF in the heated baboon. In support, the increase in leg blood flow during heating of dehydrated baboons is restored to normal after either oral ingestion (222) or intravenous infusion (223) of a sodium chloride solution that maintained the dehydration-produced hyperosmolality but reversed the hypovolemia.…”
Section: )mentioning
confidence: 67%
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“…The phenomenon of hyperthermia‐induced vasoconstriction (cancelling peripheral vasodilation despite the continuing IPH and high T h ) is likely to reflect the animal's inability to maintain cardiac output and blood pressure without shutting off blood flow in peripheral tissues. Occurring at the onset of heat exposure, water‐consuming heat‐defense responses (in our animals, polypnea) and thermoregulatory redistribution of blood toward the skin lead to dehydration and/or hypovolemia, both shown to increase the threshold T b for cutaneous vasodilation 8,9 . Our results demonstrate that hyperthermia‐induced vasoconstriction is opioid‐dependent because NTX, an opioid antagonist, prevents its occurrence.…”
Section: Discussionmentioning
confidence: 58%
“…The redistribution of blood flow from the visceral to the cutaneous circulations is strongly influenced by nonthermal inputs such as hydration status (14,29,31,36). Anatomic and in vitro evidence suggest that thermal and nonthermal information may be integrated within the AV3V (15,34,50).…”
Section: Discussionmentioning
confidence: 99%