Effects of Hyperkalaemia Upon the General and Coronary Haemodynamics of the Dog

Maxwell, George M.

doi:10.1038/icb.1965.49

Aust J Exp Biol Med

1965

DOI: 10.1038/icb.1965.49

|View full text |Cite

Effects of Hyperkalaemia Upon the General and Coronary Haemodynamics of the Dog

George M. Maxwell¹

Abstract: Summary. Vascular pressures, cardiac output (Fick) and coronary flow (NjO Fick) were measured before and after the production of hyperkalaernia in intact dogs. Respiratory exchange and heart rate increased; vascular pressures and cardiac output did not vary. There was no significant change in coronary flow, but cardiac oxygen extraction and metabolism increased.INTRODUCTION.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1969

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A study of plasma potassium and electrocardiographic changes after a single dose of succinylcholine

Evers

Racz

Dobkin

1969

Can. Anaes. Soc. J.

View full text Add to dashboard Cite

THE CUBItENT CONTROVERSY regarding the role of succinylcholine in producing cardiovascular disturbances deserves the careful attention of every anaesthesiologist. These changes, which may be catastrophic in nature, can occur after a single intravenous dose 1-~ as well as following repeated administrations. 4-9 The disturbances range from mild, transient changes in rate or rhythm through severe bradycardia and serious arrhythmias to cardiac arrest.Several theories have been offered to explain the causes, but none of them seems adequate. One of the most recent concerns the increase of plasma potassium immediately following the intravenous administration of succinylcholine.The release of plasma potassium as a result of damage to myofibrillae has been described. The occurrence of haemoglobinuria or myoglobinaemia after vigorous muscular exercises like forced marches, karate, 1~ or football 11,12 has been well documented, and several authors have described myoglobinaemia or myoglobinuria after the administration of succinylcho]ine. 13-15 A case of acute renal failure following the use of succinylcholine in a patient with idiopathic myoglobinuria was described by Bennike. 14 These phenomena (myoglobinuria, myoglobinaemia) after succinylcholine indicate myofibrillar damage and presumably the release of intracellular potassium.This study was designed to determine the incidence, magnitude and timing of plasma potassium changes and their correlation with electrocardiographic abnormalities following the administration of succinylcholine. MATERIALS AND METI-IODSOne hundred anaesthetics were studied in patients undergoing surgical procedures requiring only a single, short period of muscular relaxation and no endotracheal intubation. The reason for avoiding patients in whom intubation or other forms of pharyngeal or laryngeal manipulation would become necessary was to eliminate the likelihood of electrocardiographic abnormalities that frequently accompany such events.Eighty-nine of the one hundred patients studied were females, most of whom were undergoing vaginal gynaecological procedures; ten male patients were operated on for relatively minor orthopedic or urological problems, and one for debridement of burns. From the point of view of anaesthetic risk, the patients seemed to represent a fair sample of the usual surgical material and age groups

show abstract

A study of plasma potassium and electrocardiographic changes after a single dose of succinylcholine

Evers

Racz

Dobkin

1969

Can. Anaes. Soc. J.

View full text Add to dashboard Cite

show abstract

Hyperkalemia, hypertension and systemic acidosis without renal failure associated with a tubular defect in potassium excretion

Arnold¹,

Healy²

1969

The American Journal of Medicine

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effects of Hyperkalaemia Upon the General and Coronary Haemodynamics of the Dog

Cited by 2 publications

References 8 publications

A study of plasma potassium and electrocardiographic changes after a single dose of succinylcholine

A study of plasma potassium and electrocardiographic changes after a single dose of succinylcholine

Hyperkalemia, hypertension and systemic acidosis without renal failure associated with a tubular defect in potassium excretion

Contact Info

Product

Resources

About