Effects of hyperglycemia and mechanical stimulations on differentiation fate of mesenchymal stem cells

Control of hydrostatic pressure and osmotic stress in 3D cell culture for mechanobiological studies

“…Early studies in the design of bioreactors focused on applications of tissue regeneration [145][146][147][148][149][150][151], combining knowledge on the chemical and biological performance of different constructive materials, patterns of mechanical stimulation, and cell characterization tools [8,[152][153][154][155][156][157][158]. Integrating this basis with recent breakthroughs in tissue fabrication, biophysics, and biomaterials, should enable bottom-up strategies for the design of bioreactors that are well-suited to investigate the mechanobiology of HP and OS.…”