effects of hypercapnia and hypoxia during hypothermia

Kilmore, Mearl A.; Chase, Harold F.

doi:10.1213/00000539-196207000-00009

Cited by 3 publications

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“…Kilmore and Chase (14) reported the response of arterial pressure to inhalation of 15% 02 was essentially the same under normothermic and hypothermic conditions in dogs. Systemic circulatory and respiratory responses of cats at 26 0 C to anoxia (produced by inhalation of 10% 02 in N 2 ) were reported as very feeble by Nashat and Nail (21).…”

Section: Effect Of Hypothermia On Reflex Activity In the Anesthetizedmentioning

confidence: 95%

Cardiopulmonary Responses to Hypothermia and Certain Other Environmental Stresses

Hall¹,

Salzano²

1963

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Respiratory regulation was studied at normal and sub-normal body temperatures. Hypoxia and body temperature were found to operate reciprocally in determining utilization of oxygen in a closed environment. Respiratory and circulatory responses to imposed tracheal obstruction were studied in normothermic and hypothermic anesthetized animals. These responses were found to be related to the degree of hypoxia which developed rather than to body temperature, per se. Changes in anatomical and physiological dead space were also measured during reduction of body temperature. There were only small changes in respiratory dead space. No significant impairment of gas transport occurred at body temperatures as low as 28 0 C.

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Section: Effect Of Hypothermia On Reflex Activity In the Anesthetizedmentioning

confidence: 95%

Cardiopulmonary Responses to Hypothermia and Certain Other Environmental Stresses

Hall¹,

Salzano²

1963

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Carbon dioxide response curves during hypothermia

Ruiz

1975

Pflugers Arch.

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The responsiveness of the medullary chemoreceptors, measured by the ventilatory response to hypercapnia given in an hyperoxic gas mixture in intact anesthetized dogs has been evaluated during normothermia and at two levels of hypothermia. The response was studied in: 1) 20 dogs during normothermia, 2) 10 of these dogs at a blood temperature of 32-33 degrees C, and 3) in the other 10 dogs during deeper hypothermia (28-29 degrees C). The ventilatory response to CO2 decreased while blood temperature was lowered until the response became absent during deep hypothermia. For normothermia and both levels of hypothermia a similar oxygen drive of ventilation was found which was equivalent to approximately one fourth of the spontaneous ventilation. It is suggested, that in the deeply hypothermic animal the normal respiratory drive is apparently of peripheral (arterial) chemoreceptor origin and when this drive is nullified or significantly decreased, gentle shivering could be responsible for stimulating the respiratory center.

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Respiratory response to hypoxia with hypocapnia or normocapnia and to CO2 in hypothermic dogs

Natsui

1969

Respiration Physiology

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effects of hypercapnia and hypoxia during hypothermia

Cited by 3 publications

References 0 publications

Cardiopulmonary Responses to Hypothermia and Certain Other Environmental Stresses

Cardiopulmonary Responses to Hypothermia and Certain Other Environmental Stresses

Carbon dioxide response curves during hypothermia

Respiratory response to hypoxia with hypocapnia or normocapnia and to CO2 in hypothermic dogs

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