Effects of hydroxychloroquine and favipiravir on clinical course in outpatients with COVID-19

Ömeroğlu, Şeyda Kayhan; Temel, Fehminaz; Altun, Dilek; Öztop, Mehmet Burak

doi:10.3906/sag-2101-146

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…(2021) из 1489 амбулаторных пациентов с разной степенью тяжести COVID-19 537 получали фавипиравир, 545 -гидроксихлорохин и 407 -фавипиравир плюс гидроксихлорохин. Частота госпитализаций была одинаковой у пациентов, получавших фавипиравир и гидроксихлорохин (p=0,144) [44].…”

Section: компьютерная томография (ктunclassified

Factors associated with adverse outcome among hospitalized patients with moderate to severe COVID-19

Mishinova

Gomon

Kolbin

et al. 2023

GCP

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Aims. To consider factors associated with adverse outcome among hospitalized patients with moderate and severe COVID-19.Materials and methods. Data from 345 case histories of adult patients hospitalized with moderate to severe COVID-19 were analyzed in a single-center retrospective study. Characteristics by sex, age, number of days from disease onset to admission to hospital, duration of hospitalization, duration of disease, population characteristics by medical history of comorbidities and self-medication, outcome of hospitalization and medical technologies used in hospital conditions were given for the whole cohort of patients. All parameters were analyzed using descriptive statistics methods. Qualitative variables are given in absolute (n) and relative (%) values with 95% confidence interval. Continuous variables were presented as median and quartiles. Risk factors for mortality were determined across groups using the χ2 criterion and odds ratio.Results. There was no demonstrated effect of gender, degree of pulmonary tissue lesions on computed tomography data, or time of initiation of respiratory support on disease outcome. At the same time, the age older than 65 years as well as neoplasms, type 2 diabetes mellitus, dementia, Stage 3 arterial hypertension, chronic heart failure, coronary heart disease, myocardial infarction and stroke history, chronic obstructive pulmonary disease, bronchiectatic disease, urogenital diseases were the predictors of unfavorable outcome in patients with moderate and severe COVID-19 form. Prehospital use of antiplatelet agents, direct and indirect oral anticoagulants, drugs affecting the renin-angiotensin system, systemic glucocorticosteroids, antibiotics, antiviral drugs, and analgesics was associated with a decrease in the mortality rate in patients with moderate-to-severe COVID-19, as well as timely use of pronposition and transfer to intensive care unit.Conclusions. Our findings are partially consistent with previous reports on the effect of risk factors on COVID-19 outcomes.

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Section: компьютерная томография (ктunclassified

Factors associated with adverse outcome among hospitalized patients with moderate to severe COVID-19

Mishinova

Gomon

Kolbin

et al. 2023

GCP

View full text Add to dashboard Cite

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Treatment adherence of COVID-19 patients getting medication at home

PORSUK¹,

Cerit²

2022

Sanamed

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Introduction: Turkey has adopted outpatient treatment of COVID-19 since the beginning of the pandemic. In the outpatient treatment of COVID-19 in Turkey, only hydroxychloroquine was initially used, favipiravir was added to the treatment, and finally, hydroxychloroquine was removed from the treatment and only favipiravir was used. Our study aims to examine the adherence to the recommended treatment of people diagnosed with COVID-19 who have received outpatient treatment without hospitalization and their attitudes and declared behaviors towards using the medications they were given free of charge. Methods: This follow-up study was conducted between February 15, 2021, and May 15, 2021, by telephone survey method in the Lüleburgaz District of Kırklareli City. The study participants were 4368 people who were diagnosed with COVID-19 with a positive PCR test in Lüleburgaz District between February 15 and May 15, 2021, and were given hydroxychloroquine and/or favipiravir drugs for home use after being deemed suitable for outpatient treatment according to the guidelines of the Republic of Turkey Ministry of Health. Results: 88.1% (n=3849) of the survey respondents reported using the given medications regularly, while 11.9% (n=519) did not use them regularly. The most important socio demographic factor affecting the regular use was age, and the patient-centered factor was the sense of trust. Conclusion: In the fight against COVID-19, measures to increase the sense of trust of patients who are expected to adhere to the treatments should be considered a priority.

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Effects of hydroxychloroquine and favipiravir on clinical course in outpatients with COVID-19

Cited by 2 publications

References 20 publications

Factors associated with adverse outcome among hospitalized patients with moderate to severe COVID-19

Factors associated with adverse outcome among hospitalized patients with moderate to severe COVID-19

Treatment adherence of COVID-19 patients getting medication at home

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