Effects of hydroxyapatite-coated porous titanium scaffolds functionalized by exosomes on the regeneration and repair of irregular bone

Shao, Hanyu; Zhang, Qiyue; Sun, Mingman; Wu, Ming; Sun, Xu; Wang, Qiang; Tong, Shuang

doi:10.3389/fbioe.2023.1283811

Cited by 4 publications

(2 citation statements)

References 61 publications

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“…Porous titanium alloy materials have an elastic modulus matching that of human bone tissue, effectively solving the elastic mismatch between implants and human bone [ 113 , 114 , 115 , 116 , 117 , 118 , 119 ]. Recently, additive manufacturing technology has been used to prepare porous titanium alloy materials [ 120 , 121 , 122 , 123 , 124 , 125 ].…”

Section: Tribocorrosion Behavior Of Titanium Alloymentioning

confidence: 99%

Tribocorrosion and Surface Protection Technology of Titanium Alloys: A Review

Li,

Zhou,

2023

Materials

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Titanium alloy has the advantages of high specific strength, good corrosion resistance, and biocompatibility and is widely used in marine equipment, biomedicine, aerospace, and other fields. However, the application of titanium alloy in special working conditions shows some shortcomings, such as low hardness and poor wear resistance, which seriously affect the long life and safe and reliable service of the structural parts. Tribocorrosion has been one of the research hotspots in the field of tribology in recent years, and it is one of the essential factors affecting the application of passivated metal in corrosive environments. In this work, the characteristics of the marine and human environments and their critical tribological problems are analyzed, and the research connotation of tribocorrosion of titanium alloy is expounded. The research status of surface protection technology for titanium alloy in marine and biological environments is reviewed, and the development direction and trends in surface engineering of titanium alloy are prospected.

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Section: Tribocorrosion Behavior Of Titanium Alloymentioning

confidence: 99%

Tribocorrosion and Surface Protection Technology of Titanium Alloys: A Review

Li,

Zhou,

2023

Materials

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“…Therefore, they need to have a good degradation ability, biological activity, cell response, and suitable mechanical properties [ 1 ]. At present, there are many different types of materials applied in bone scaffolds including polymers, ceramics, and metals; they each have their own advantages and disadvantages [ 2 , 3 , 4 ]. Synthetic polymers are currently the most widely studied scaffold materials, especially biodegradable polymer materials [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium Hydroxide as a Versatile Nanofiller for 3D-Printed PLA Bone Scaffolds

Guo,

Bu,

Mao

et al. 2024

Polymers

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Polylactic acid (PLA) has attracted much attention in bone tissue engineering due to its good biocompatibility and processability, but it still faces problems such as a slow degradation rate, acidic degradation product, weak biomineralization ability, and poor cell response, which limits its wider application in developing bone scaffolds. In this study, Mg(OH)2 nanoparticles were employed as a versatile nanofiller for developing PLA/Mg(OH)2 composite bone scaffolds using fused deposition modeling (FDM) 3D printing technology, and its mechanical, degradation, and biological properties were evaluated. The mechanical tests revealed that a 5 wt% addition of Mg(OH)2 improved the tensile and compressive strengths of the PLA scaffold by 20.50% and 63.97%, respectively. The soaking experiment in phosphate buffered solution (PBS) revealed that the alkaline degradation products of Mg(OH)2 neutralized the acidic degradation products of PLA, thus accelerating the degradation of PLA. The weight loss rate of the PLA/20Mg(OH)2 scaffold (15.40%) was significantly higher than that of PLA (0.15%) on day 28. Meanwhile, the composite scaffolds showed long-term Mg2+ release for more than 28 days. The simulated body fluid (SBF) immersion experiment indicated that Mg(OH)2 promoted the deposition of apatite and improved the biomineralization of PLA scaffolds. The cell culture of bone marrow mesenchymal stem cells (BMSCs) indicated that adding 5 wt% Mg(OH)2 effectively improved cell responses, including adhesion, proliferation, and osteogenic differentiation, due to the release of Mg2+. This study suggests that Mg(OH)2 can simultaneously address various issues related to polymer scaffolds, including degradation, mechanical properties, and cell interaction, having promising applications in tissue engineering.

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The Exosome‐Mediated Bone Regeneration: An Advanced Horizon Toward the Isolation, Engineering, Carrying Modalities, and Mechanisms

Zhu,

Wang,

Wang

et al. 2024

Adv Healthcare Materials

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Exosomes, nanoparticles secreted by various cells, composed of a bilayer lipid membrane, and containing bioactive substances such as proteins, nucleic acids, metabolites, etc., have been intensively investigated in tissue engineering owing to their high biocompatibility and versatile biofunction. However, there is still a lack of a high‐quality review on bone defect regeneration potentiated by exosomes. In this review, we will first introduce the biogenesis and isolation methods of exosomes, More importantly, the engineered exosomes of the current state of knowledge will be discussed intensively in this review. Afterward, the biomaterial carriers of exosomes and the mechanisms of bone repair elucidated by compelling evidence will be presented. Thus, future perspectives and concerns are revealed to help devise advanced modalities based on exosomes to overcome the challenges of bone regeneration. We totally believe this review will attract special attention from clinicians and provide promising ideas for their future works.This article is protected by copyright. All rights reserved

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Effects of hydroxyapatite-coated porous titanium scaffolds functionalized by exosomes on the regeneration and repair of irregular bone

Cited by 4 publications

References 61 publications

Tribocorrosion and Surface Protection Technology of Titanium Alloys: A Review

Tribocorrosion and Surface Protection Technology of Titanium Alloys: A Review

Magnesium Hydroxide as a Versatile Nanofiller for 3D-Printed PLA Bone Scaffolds

The Exosome‐Mediated Bone Regeneration: An Advanced Horizon Toward the Isolation, Engineering, Carrying Modalities, and Mechanisms

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