Effects of hydrogen-rich water on aging periodontal tissues in rats

Tomofuji, Takaaki; Kawabata, Yuya; Kasuyama, Kenta; Endo, Yoshikatsu; Yoneda, Toshiki; Yamane, Mayu; Azuma, Tetsuji; Ekuni, Daisuke; Morita, Manabu

doi:10.1038/srep05534

Cited by 28 publications

(28 citation statements)

References 31 publications

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“…In contrast, serum levels of ROM were concentration-dependently lower in the 0.62% and 1.36% coffee groups than in the control group, but the differences did not reach statistical significance. A previous study identified a significant reduction in serum ROM in rats after continuous intake of hydrogen-rich water for >10 months (26). Our model involved continuous coffee intake for 12 weeks, which might have been insufficient to reduce systemic oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue

Kobayashi

Maruyama

Yoneda

et al. 2020

In Vivo

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Background/Aim: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss. Materials and Methods: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks. Results: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group. Conclusion: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue

Kobayashi

Maruyama

Yoneda

et al. 2020

In Vivo

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“…10 Drinking hydrogen-rich water had anti-oxidative effect on aging periodontal tissues. 11 These observations lead us to speculate that hydrogen-rich saline may play a protective role in the pathogenesis of COPD.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats

Liu

Geng

Jiang

et al. 2017

Exp Biol Med (Maywood)

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This study was designed to evaluate protective effect of hydrogen-rich saline, a novel antioxidant, on tobacco smoke (TS)-induced chronic obstructive pulmonary disease (COPD) in rats and explore the underlying mechanism. Our results suggest that administration of hydrogen-rich saline improves lung function and alleviates morphological impairments of lung through alleviating inflammation, reducing oxidative stress and lessening mucus hypersecretion in TS-induced COPD rats. AbstractChronic obstructive pulmonary disease induced by tobacco smoke has been regarded as a great health problem worldwide. The purpose of this study is to evaluate the protective effect of hydrogen-rich saline, a novel antioxidant, on chronic obstructive pulmonary disease and explore the underlying mechanism. Sprague-Dawley rats were made chronic obstructive pulmonary disease models via tobacco smoke exposure for 12 weeks and the rats were treated with 10 ml/kg hydrogen-rich saline intraperitoneally during the last 4 weeks. Lung function testing indicated hydrogen-rich saline decreased lung airway resistance and increased lung compliance and the ratio of forced expiratory volume in 0.1 s/forced vital capacity in chronic obstructive pulmonary disease rats. Histological analysis revealed that hydrogen-rich saline alleviated morphological impairments of lung in tobacco smoke-induced chronic obstructive pulmonary disease rats. ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum of chronic obstructive pulmonary disease rats. The content of malondialdehyde in lung tissue and serum was also determined and the data indicated hydrogen-rich saline suppressed oxidative stress reaction. The protein expressions of mucin MUC5C and aquaporin 5 involved in mucus hypersecretion were analyzed by Western blot and ELISA and the data revealed that hydrogen-rich saline down-regulated MUC5AC level in bronchoalveolar lavage fluid and lung tissue and up-regulated aquaporin 5 level in lung tissue of chronic obstructive pulmonary disease rats. In conclusion, these results suggest that administration of hydrogen-rich saline exhibits significant protective effect on chronic obstructive pulmonary disease through alleviating inflammation, reducing oxidative stress and lessening mucus hypersecretion in tobacco smoke-induced chronic obstructive pulmonary disease rats.

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“…For example, rats were fed H 2 -water (0.19 mM hydrogen) or degassed water ad libitum for one year, and there were no reported changes in morbidity or mortality between the H 2 and control group of animals. There was, however, reduced periodontal damage in the H 2 group [53]. In clinical studies there were no reported toxic effects of ingesting H 2 [54].…”

Section: Safety Of Hydrogenmentioning

confidence: 80%

“…Another approach has been to drink H 2 -water. Using healthy four month-old rats fed H 2 -enriched or control water the effects of H 2 -water have been examined in aging periodontal tissues [236]. The animals fed H 2 -water and control water were examined after 16 months.…”

Section: Hydrogen In Skin and Agingmentioning

confidence: 99%

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

Nicolson¹,

Ferreira²,

Settineri³

et al. 2016

IJCM

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Here we review the literature on the effects of molecular hydrogen (H2) on normal human subjects and patients with a variety of diagnoses, such as metabolic, rheumatic, cardiovascular and neurodegenerative and other diseases, infections and physical and radiation damage as well as effects on aging and exercise. Although the effects of H2 have been studied in multiple animal models of human disease, such studies will not be reviewed in depth here. H2 can be administered as a gas, in saline implants or infusions, as topical solutions or baths or by drinking H2-enriched water. This latter method is the easiest and least costly method of administration. There are no safety issues with hydrogen; it has been used for years in gas mixtures for deep diving and in numerous clinical trials without adverse events, and there are no warnings in the literature of its toxicity or longterm exposure effects. Molecular hydrogen has proven useful and convenient as a novel antioxidant and modifier of gene expression in many conditions where oxidative stress and changes in gene expression result in cellular damage.

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Effects of hydrogen-rich water on aging periodontal tissues in rats

Cited by 28 publications

References 31 publications

Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue

Effects of Coffee Intake on Oxidative Stress During Aging-related Alterations in Periodontal Tissue

Hydrogen-rich saline inhibits tobacco smoke-induced chronic obstructive pulmonary disease by alleviating airway inflammation and mucus hypersecretion in rats

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

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