Effects of hydroethanolic extracts of Balanites aegyptiaca (L.) Delile (Balanitaceae) on some resistant pathogens bacteria isolated from wounds

Anani, Kokou; Adjrah, Yao; Ameyapoh, Yaovi; Karou, Simplice Damintoti; Agbonon, Amégnona; Souza, Comlan de; Gbéassor, Messanvi

doi:10.1016/j.jep.2015.01.051

Cited by 27 publications

(15 citation statements)

References 29 publications

(30 reference statements)

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“…The results obtained showed that the activities of the extracts increased with increasing concentration and showed antimicrobial activity to both gram positive and negative test organisms [55] , suggesting that they may have a broad spectrum activity. This trend was seen in other works where different extracts and parts of the plants, and in combination with other plants have shown activity against S. aureus and E. coli [56], S. aureus, E. coli, S. typhimurium and S. dysentriae [55], S. aureus, E. coli, S. typhimurium and S. dysentriae [55], S aureus [50], S. E. coli [57], S. typhimurium ATCC 23564 and E. coli [49] and others [22,28,50]. The plant extracts have also been reported to have antifungal activity against Aspergillus niger and C. albicans, with minimal fungicidal concentration, MFC of 250 mg/ml [25].…”

Section: Discussionsupporting

confidence: 70%

The Antibacterial Activity of Aqueous and Ethanolic Leaf Extracts of Balanites aegyptiaca (l.) Del Plant on Some Selected Clinical Human Pathogens

Ezemokwe

Aguiyi

Chollom

2020

JAMB

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The antibacterial activity of the leaf extract of Balanites aegyptiaca plant was investigated on five selected clinical common human pathogens: Staphylococcus aureus, Streptococcus pneumonia, Salmonella typhimurium, Shigella dysentriae and Escherichia coli, in vitro. The phytochemical screening, susceptibility testing and Minimal Inhibitory Concentrations were determined. Preliminary phytochemical screening of the leaf extracts indicated the presence of alkaloids, cardiac glycosides, flavonoids, glycosides, resins, saponins, steroids, tannins, and carbohydrates in varying concentrations. Ethanolic leaf extract was more effective. The extracts inhibited the growth of isolates with increasing concentrations, ranging from 8-12 mm zones of inhibitions, showing the susceptibility of the test organisms. S. dysentriae had the highest susceptibility for both extracts with 12 mm and 13 mm zones of inhibition for aqueous and ethanolic extracts respectively at the highest concentration of 400 mg/ml. S. aureus showed the least susceptibility with 8 mm for aqueous extract while S. typhimurium showed the least susceptibility for the ethanolic extract with 9mm zones of inhibition. The analysis of variance results on zones of inhibition revealed a significant difference for both extract treatments, concentrations, and interactions between the treatments and concentrations. The Minimal Inhibitory Concentrations determined from the corresponding concentration-response curves showed that S. dysentriae had the least value of 79.433 mg/ml while the aqueous extracts against S. aureus and S. typhimurium were the largest with 125.893 mg/ml value. The activity index and activity were also deduced to measure activity. The antimicrobial activity of leaf extracts of B. aegyptiaca on bacteria of the tested isolates have been established in this study and justify the claims by the traditional healers in its use to treat infectious diseases.

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Section: Discussionsupporting

confidence: 70%

The Antibacterial Activity of Aqueous and Ethanolic Leaf Extracts of Balanites aegyptiaca (l.) Del Plant on Some Selected Clinical Human Pathogens

Ezemokwe

Aguiyi

Chollom

2020

JAMB

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“…Traditional Chinese medicines are a valuable source for novel antibacterial agents [35–37]. The inhibitory effect of the water extract of H. patriniae against P. aeruginosa biofilms and biofilm-related phenotypes signifies that H. patriniae is a promising candidate for treatment of infections caused by P. aeruginosa biofilms.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae

Dang

et al. 2017

BioMed Research International

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New antimicrobial agents are urgently needed to treat infections caused by drug-resistant pathogens and by pathogens capable of persisting in biofilms. The aim of this study was to identify traditional Chinese herbs that could inhibit biofilm formation of Pseudomonas aeruginosa, an important human pathogen that causes serious and difficult-to-treat infections in humans. A luxCDABE-based reporter system was constructed to monitor the expression of six key biofilm-associated genes in P. aeruginosa. The reporters were used to screen a library of 36 herb extracts for inhibitory properties against these genes. The results obtained indicated that the extract of Herba patriniae displayed significant inhibitory effect on almost all of these biofilm-associated genes. Quantitative analysis showed that H. patriniae extract was able to significantly reduce the biofilm formation and dramatically altered the structure of the mature biofilms of P. aeruginosa. Further studies showed H. patriniae extract decreased exopolysaccharide production by P. aeruginosa and promoted its swarming motility, two features disparately associated with biofilm formation. These results provided a potential mechanism for the use of H. patriniae to treat bacterial infections by traditional Chinese medicines and revealed a promising candidate for exploration of new drugs against P. aeruginosa biofilm-associated infections.

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“…It may lead to the negative influence of antibiotics on natural microflora of the skin and lead to resistance of many bacterial strains [ 110 ]. Thus the activity of polyphenols has special significance in the case of strains resistant to antibiotics, e.g., Staphylococcus aureus resistant to methicillin, enterococci resistant to glycopeptide antibiotics and vancomycin, pneumococci resistant to β-lactam and macrolides, and Pseudomonas aeruginosa with its defense mechanism against phagocytic activity of polymorphonuclear leucocytes [ 109 , 111 , 112 ]. Bacteria of the genera Staphylococcus , Pseudomonas and Enterococcus are the most frequent causes of hospital infections of skin wounds such as ulcers, bedsores or burns that result in many healing problems [ 113 , 114 ].…”

Section: Health-promoting Activity Of Phenolic Compounds Based On mentioning

confidence: 99%

“…The developing pharmacological market provides a variety of products supporting the healing process. Unfortunately, the side effects of these products, lack of radical treatment for some chronic wounds, the high cost of conventional medicines and microbiological resistance of strains inhabiting the wound environment lead to the increasing use of plants in medicine [ 112 ]. Phenolic compounds found in some medicinal plants in high concentrations make plants an important resource to search for new therapeutic agents.…”

Section: The Effect Of Phenolic Compounds On Healing Of Incised Anmentioning

confidence: 99%

“…The health-promoting character of the plant was the background of research that proved the antioxidant and antibacterial properties of water-ethanol extract from the soap berry tree’s bark. It was revealed that this extract has antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa strains isolated from hospitalized patients’ wounds [ 112 ]. It is also known that, e.g., sophoraflavanone G exhibits antibacterial activity, reducing the fluidity of bacterial cells, and galangin causes significant loss of potassium content in Staphylococcus aureus cells, which may contribute to the direct damage of the cytoplasmic membrane or indirect disturbance leading to weakening of the cell membrane and consequently to osmotic lysis [ 115 ].…”

Section: The Effect Of Phenolic Compounds On Healing Of Incised Anmentioning

confidence: 99%

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The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

Działo

Mierziak

Korzun

et al. 2016

IJMS

537

327

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Phenolic compounds constitute a group of secondary metabolites which have important functions in plants. Besides the beneficial effects on the plant host, phenolic metabolites (polyphenols) exhibit a series of biological properties that influence the human in a health-promoting manner. Evidence suggests that people can benefit from plant phenolics obtained either by the diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. Due to their natural origin and low toxicity, phenolic compounds are a promising tool in eliminating the causes and effects of skin aging, skin diseases, and skin damage, including wounds and burns. Polyphenols also act protectively and help prevent or attenuate the progression of certain skin disorders, both embarrassing minor problems (e.g., wrinkles, acne) or serious, potentially life-threatening diseases such as cancer. This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.

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Effects of hydroethanolic extracts of Balanites aegyptiaca (L.) Delile (Balanitaceae) on some resistant pathogens bacteria isolated from wounds

Cited by 27 publications

References 29 publications

The Antibacterial Activity of Aqueous and Ethanolic Leaf Extracts of Balanites aegyptiaca (l.) Del Plant on Some Selected Clinical Human Pathogens

The Antibacterial Activity of Aqueous and Ethanolic Leaf Extracts of Balanites aegyptiaca (l.) Del Plant on Some Selected Clinical Human Pathogens

Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae

The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders

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