Effects of hydrodynamic conditions (diffusion vs. convection) and solution chemistry on effective molecular weight cut-off of negatively charged nanofiltration membranes

Kang, Eunyoung; Lee, Yunho; Chon, Kangmin; Cho, Jaeweon

doi:10.1016/j.desal.2014.08.016

Cited by 15 publications

(8 citation statements)

References 32 publications

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“…Methods based on rejection data of solutes are proven to be more indicative methods for characterization of membrane separation performance [20]. In this work, the solute transport method was applied to estimate the mean pore size of the UF membranes, while the log normal distribution curves were used to describe the pore size distribution, more detailed description of the procedure was given by [16].…”

Section: Solute Transport Methodsmentioning

confidence: 99%

Investigation of UF membranes fouling and potentials as pre-treatment step in desalination and surface water applications

2018

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Section: Solute Transport Methodsmentioning

confidence: 99%

Investigation of UF membranes fouling and potentials as pre-treatment step in desalination and surface water applications

2018

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“…Membrane-based separation processes have been routinely used for the separation and purification of bioactive peptides obtained from different protein sources. In pressure-driven separation processes, the separation capacity of a filtration membrane (FM) is greatly affected by its pore size and pore size distribution (PSD) as they control either passage or rejection of a molecule through FM [1]. The pore size and PSD of commercially available ultrafiltration (UF) and nanofiltration (NF) membranes, the major types of membranes used for peptides separation/concentration in pressure-driven processes, are measured in terms of nominal molecular weight cut-offs (MWCO) by using solute rejection method [2].…”

Section: Introductionmentioning

confidence: 99%

How Molecular Weight Cut-Offs and Physicochemical Properties of Polyether Sulfone Membranes Affect Peptide Migration and Selectivity during Electrodialysis with Filtration Membranes

et al. 2019

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Filtration membranes (FMs) are an integral part of electrodialysis with filtration membranes (EDFM), a green and promising technology for bioactive peptide fractionation. Therefore, it is paramount to understand how physicochemical properties of FMs impact global and selective peptide migration to anionic (A−RC) and cationic (C+RC) peptide recovery compartments during their simultaneous separation by EDFM. In this context, six polyether sulfone (PES) membranes with molecular weight cut-offs (MWCO) of 5, 10, 20, 50, 100 and 300 kDa were characterized and used during EDFM to separate peptides from a complex whey protein hydrolysate. Surface charge, roughness, thickness and surface/pores nature of studied PES membranes were similar with small differences in conductivity, porosity and pore size distribution. Interestingly, global peptides migration to both recovery compartments increased linearly as a function of MWCO. However, peptide selectivity changed according to the recovery compartments and/or the peptide’s charge and MW with an increase in MWCO of FMs. Indeed, in A−RC, the relative abundance (RA) of peptides having low negative charge and MW (IDALNENK and VLVLDTDYK) decreased (45% to 19%) with an increase in MWCO, while the opposite for peptides having high negative charge and MW (TPEVDDEALEK, TPEVDDEALEKFDK & VYVEELKPTPEGDLEILLQK) (increased from 16% to 43%). Concurrently, in C+RC, regardless of MWCO used, the highest RA was observed for peptides having low positive charge and MW (IPAVFK & ALPMHIR). It was the first time that the significant impact of charge, MWCO and pore size distribution of PES membranes on a wide range of MWCO was demonstrated on EDFM performances.

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“…However, the method used to determine the MWCO have utilized a high-end equipment of HPLC coupled with ELSD detector though using PEGs as the solutes. Other work has also used gas chromatography (GC) with specific column to determine the styrene derivatives [10], alkanes detected in HPLC [30]. Based on this comparison study, the newly modified method is confirmed can accurately determine the MWCO in the range of 500 to 20,000 g/mol, which indicates the reliability of this method to substitute the method currently referred to [16].…”

Section: Commercial Membranes Solute Filtration Testmentioning

confidence: 73%

“…Each of these methods has its own advantages and limitations. Some of the techniques outlined might not be useful in the determination of pore size of membranes in term of their molecular weight cut-off (MWCO) since they cannot predict the membranes' sieving effects based on the removal of particles and solutes through the membranes under actual operating conditions and transport mechanism [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Among the outlined methods, the solute rejection method is an effective technique to investigate the separation characteristics of various solutes by membranes because it measures solute rejection using actual filtration experiments with non-ionic solutes of a known molecular weight (MW) such as polyethylene glycol (PEG), oligostyrenes, alkanes and dextrans [10]. A membrane's MWCO is a representation of membrane selectivity for solute molecules of different MW, where the MW value is obtained from the solute molecule that gives a 90% rejection when a range of different MW solutes are filtered in the targeted solvent [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Molecular Weight Cut-Off Determination of Pressure Filtration Membranes via Colorimetric Detection Method

Yusoff

Rohani²,

Mohammad³

2017

MJAS

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Molecular weight cutoff (MWCO) of commercial and in-house fabricated membranes is obtained at 90% rejection of various types of solutes with different molecular weights (MWs). PEG quantification methods have been favorably employed to determine membranes' MWCO. Most of the quantification methods utilizing high-end equipment using high performance liquid chromatography (HPLC) and low-end colorimetric method. HPLC method requires an established chromatographic technique using specific diluents, columns and detectors while the most referred colorimetric method requires a few processing steps with concentration up to 7.5 ppm by using UV spectrophotometer. In this work, a newly modified colorimetric method was established to conduct a simple measurement for a membrane's MWCO. The newly modified method has an excellent linearity for the calibration curves which R 2 values are closed to 1 with concentration of up to 150 ppm. A MWCO determination test conducted using different commercial membranes for confirming this newly modified method found that similar MWCO values were obtained as given by the membrane' manufacturers. In conclusion, this newly modified method is simpler than the formerly used colorimetric method, reliable and applicable for determining the MWCO of membranes ranging from UF to NF at a higher range of PEG concentrations (>150 ppm).

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Effects of hydrodynamic conditions (diffusion vs. convection) and solution chemistry on effective molecular weight cut-off of negatively charged nanofiltration membranes

Cited by 15 publications

References 32 publications

Investigation of UF membranes fouling and potentials as pre-treatment step in desalination and surface water applications

Investigation of UF membranes fouling and potentials as pre-treatment step in desalination and surface water applications

How Molecular Weight Cut-Offs and Physicochemical Properties of Polyether Sulfone Membranes Affect Peptide Migration and Selectivity during Electrodialysis with Filtration Membranes

Molecular Weight Cut-Off Determination of Pressure Filtration Membranes via Colorimetric Detection Method

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