Effects of hydrochemistry variables on the half-life of mancozeb and on the hazard index associated to the sum of mancozeb and ethylenethiourea

López‐Fernández, Olalla; Pose-Juan, Eva; Rial-Otero, R.; Simal‐Gándara, Jesús

doi:10.1016/j.envres.2017.01.016

Cited by 25 publications

(11 citation statements)

References 23 publications

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“…The body metabolizes the mancozeb quickly, and animal studies show low-acute toxicity. However, experiments on rodents presented that mancozeb and its metabolite, ethylene thiourea (ETU), can cross the placental barrier and disrupt reproductive performance, lead DNA damage, and also initiate fetal cell tumors 2,[7][8][9] . Mancozeb is a multipotent carcinogen with long-term exposure in laboratory animals 10 .…”

Section: Introductionmentioning

confidence: 99%

Histopathological, immunohistochemical and biochemical alterations in liver tissue after fungicide-mancozeb exposures in Wistar albino rats

Gök

Deveci

2022

Acta Cir. Bras.

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To evaluate the histopathological, immunohistochemical, and biochemical effects of liver changes after mancozeb administration.Methods: Rats were divided into groups-the control group (n=7) and the mancozeb group (n=7)-, given 500 mg/kg mancozeb dissolved in corn oil daily for four weeks by an orogastric tube. Caspase-3 and tumor necrosis factor-alpha (TNF-α) primary antibodies were used for immunohistochemical analysis. Results: Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values of the mancozeb group increased significantly than ones of the control group. Venous dilatation, inflammation, hepatocyte degeneration, TNF-α, and caspase-3 expression scores increased significantly in the mancozeb group. In the mancozeb group, intensive caspase-3 expression was observed in hepatocyte cells around the central vein in the center of the liver lobule, and there was an increase in TNF-α expression in the inflammatory cells around the enlarged central vein and Kupffer cells and apoptotic hepatocyte cells. Conclusion: Subacute mancozeb exposure in rats leads to elevated toxicity with impaired liver function, increased inflammation in tissue and increased apoptosis due to cellular damage in the liver, and decreased liver regeneration ability due to congestion and degeneration of blood vessels.

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Section: Introductionmentioning

confidence: 99%

Histopathological, immunohistochemical and biochemical alterations in liver tissue after fungicide-mancozeb exposures in Wistar albino rats

Gök

Deveci

2022

Acta Cir. Bras.

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“…Due to its high solubility in water, ETU is more toxic than MCZ and it can contaminate aquifers. Furthermore, ETU has been classified as probably carcinogenic in humans and has been associated with neurotoxic problems [10]. The degradation of some pesticides in water has been reported, but only a few studies have been found that investigate MCZ and ETU [11,12].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Characterization of Mancozeb Degradation for Wastewater Treatment Using a Sensor Based on Poly (3,4-ethylenedioxythiophene) (PEDOT) Modified with Carbon Nanotubes and Gold Nanoparticles

et al. 2019

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Mancozeb is a worldwide fungicide used on a large scale in agriculture. The active component and its main metabolite, ethylene thiourea, has been related to health issues. Robust, fast, and reliable methodologies to quantify its presence in water are of great importance for environmental and health reasons. The electrochemical evaluation of mancozeb using a low-cost electrochemical electrode modified with poly (3,4-ethylene dioxythiophene), multi-walled carbon nanotubes, and gold nanoparticles is a novel strategy to provide an in-situ response for water pollution from agriculture. Additionally, the thermal-, electrochemical-, and photo-degradation of mancozeb and the production of ethylene thiourea under controlled conditions were evaluated in this research. The mancozeb solutions were characterized by electrochemical oxidation and ultraviolet-visible spectrophotometry, and the ethylene thiourea concentration was measured using ultra-high-performance liquid chromatography high-resolution mass spectrometry. The degradation study of mancozeb may provide routes for treatment in wastewater treatment plants. Therefore, a low-cost electrochemical electrode was fabricated to detect mancozeb in water with a robust electrochemical response in the linear range as well as a quick response at a reduced volume. Hence, our novel modified electrode provides a potential technique to be used in environmental monitoring for pesticide detection.

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“…Moreover, it can be a source of surface and groundwater contamination and is considered extremely toxic to amphibians, slightly toxic to fish and mildly toxic to crustaceans (ROEDE et al, 2014). ETU is classified as an animal carcinogen, and a probable human carcinogen (group B2) based on carcinogenicity tests carried out in animals (HURLEY, 1998;LÓPEZ-FERNÁNDEZ et al, 2017). Also, chronic exposure to this product has been linked to negative effects on the digestive system, the thyroid gland and the nervous system (HAYAMA et al, 2008;LÓPEZ-FERNÁNDEZ et al, 2017).…”

Section: Establishment Of the Environmental Impact Quotient In The Fieldmentioning

confidence: 99%

Evaluation of proposed integrated diseases management strategies in blackberry cultivation according to its sustainability

Zapata-Narváez¹,

Beltrán-Acosta²

2019

Rev. Bras. Frutic.

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The production of blackberry in Colombia is a source of income and rural employment in 18 departments; however, the plant is affected by diseases such as gray mold, anthracnose and powdery mildew that can cause losses of up to 70%. The control of these diseases is mainly carried out with chemical fungicides such as benomyl, carbendazim and mancozeb applied every 7 or 15 days. Nevertheless, being a continuous fructification plant of weekly harvest, the proximity between the application of the pesticides, the harvest, and its consumption represents a health risk due to the residually of these molecules, condition that affects its innocuousness and sustainability. Accordingly, this work aimed to develop an integrated management strategy for these diseases. Two strategies were proposed integrating agricultural labors with applications of Tricotec®-Kendal® or Tricotec®-EcoSwing®, and three fungicides applied according to the incidence of each disease, compared with the diseases producer management. In 77 evaluation days the effectiveness of the strategies was assessed according diseases incidence reduction, on fruit production, environmental impact, using the environmental impact quotient in the field (EIQf), and the reduction of fruit pesticides residues. According to the results obtained, the strategy Tricotec®-Kendal® with applications of a fungicide based on azoxystrobin + difeconazole showed the lowest diseases incidence, averaging 3% for gray mold, 11% for anthracnose, and 21% for powdery mildew and the highest amount of fruit harvested averaging 5,668 g. The strategy showed the lowest EIQf (5.3) compared with a value of 81.50 obtained with the traditional producer management, as well as the least amount of pesticides residues, corresponding to azoxystrobin (0.10 mg/kg) and difeconazole (0.046 mg/kg); these, however, remained within the maximum residue limits for pesticides stated by the European Union for blackberry.

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Effects of hydrochemistry variables on the half-life of mancozeb and on the hazard index associated to the sum of mancozeb and ethylenethiourea

Cited by 25 publications

References 23 publications

Histopathological, immunohistochemical and biochemical alterations in liver tissue after fungicide-mancozeb exposures in Wistar albino rats

Histopathological, immunohistochemical and biochemical alterations in liver tissue after fungicide-mancozeb exposures in Wistar albino rats

Electrochemical Characterization of Mancozeb Degradation for Wastewater Treatment Using a Sensor Based on Poly (3,4-ethylenedioxythiophene) (PEDOT) Modified with Carbon Nanotubes and Gold Nanoparticles

Evaluation of proposed integrated diseases management strategies in blackberry cultivation according to its sustainability

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