Effects of hydroalcoholic extract of Solidago chilensis Meyen on nociception and hypernociception in rodents

Abstract

BackgroundSolidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of the native medicinal herbal plants used in the Brazilian public health system. In addition to its anti-inflammatory properties, a recent clinical study has shown antinociceptive effects of S. chilensis, introducing a new potential medical use for this plant. The aim of the present study was to investigate the antinociceptive activity of the hydroalcoholic extract of Solidago chilensis (HESc) in rodent models of pain.MethodsThe dried plant extract was obtained from its aerial parts, maintained in ethanol (100 g/l) and filtered. Rats or mice were treated with intraperitoneal injections of HESc (3, 10 or 30 mg/kg) 30 min before being submitted to writhing, 0.2%-formaline or hot-plate tests or prostaglandin E2 (PGE2) administration in the hind paw. Mechanical hypernociception and motor impairment were evaluated by electronic von Frey and rota-rod, respectively.ResultsHESc dose-dependently inhibited abdominal contortions in the writhing test and attenuated phases I and II formalin-induced nociceptive behavior. Treatment with HESc also increased thermal threshold and decreased PGE2-induced hypernociception without promoting motor impairment.ConclusionsOur data suggest that, when systemically administered, HESc decreases nociception without inducing a sedative effect. Importantly, this effect was observed in both inflammatory and non-inflammatory models of pain and nociception, suggesting a specific non-inflammatory mechanism of HESc on pain. Our findings indicate that S. chilensis might be an important adjuvant in pain management.

A administração sistêmica de extratos de arnica é segura? Uma revisão sistemática de ensaios pré-clínicos

“…These articles were read in full and analyzed according to the eligibility criteria. Therefore, six articles were excluded due to following reasons: three articles included animals with comorbidity (Rodrigues et al, 2016;Schneider et al, 2015;Sharma et al, 2016); two article did not configure models of oral or intraperitoneal intoxication (Khuda-bukhsh & Chakrabart, 1998;Malpezzi-Marinho et al, 2019); and one research did not evaluate an arnica species (Mishra et al, 2011). Therefore, five studies (Bucciarelli et al, 2010;Facury Neto et al, 2004;Ferrari et al, 2012;Ferreira et al, 2014;Paula-Freire et al, 2014) were included in qualitative synthesis.…”

“…Therefore, though previous reports on the therapeutic benefits of several arnica preparations were carried out at lower doses following full concentration of the extracts (Assini et al, 2013;de Sá Müller et al, 2019;Facury Neto et al, 2004;Malpezzi-Marinho et al, 2019;Mercandeli et al, 2012;Sabir et al, 2012;Schneider et al, 2015), and this concentration does not occur in the real traditional therapeutic practice; it is still not conceivable to guarantee whether the folk claims for the systemic use of "Brazilian arnicas" in acute inflammatory ailments is safe or not.…”

“…As regards the treatment groups (TG), the ethanolic extracts of the aerial parts (EEAP), i.e., flowers, leaves and steams, were the most used arnica derivatives in the studies (Ferrari et al, 2012;Ferreira et al, 2014;Malpezzi-Marinho et al, 2019;Paula-Freire et al, 2014), thereby accounting for 60 % of the reports. Conversely, the aqueous extracts of aerial parts (AEAP) accounted for 40 % of the evaluated herbal medicines (Bucciarelli et al, 2010;Facury Neto et al, 2004).…”

Assessment of the In Vitro Antischistosomal Activities of the Extracts and Compounds from Solidago Microglossa DC (Asteraceae) and Aristolochia Cymbifera Mart. & Zucc. (Aristolochiaceae)

“…Solidago microglossa De Candolle (Asteraceae), synonymy S . chilensis Meyen, is a medicinal plant known as “arnica-do-campo” and “erva-lanceta” that possess a very widely popular therapeutic applications in South America, including as anti-inflammatory [ 10 , 11 ] and anthelmintic [ 12 , 13 ]. Due to its high medicinal importance in Brazil, since 2009, S .…”

“…Due to its high medicinal importance in Brazil, since 2009, S . microglossa is included in the National List of Medicinal Plants of Interest to the Brazilian Unified Health System (RENISUS) [ 10 , 11 , 13 ].…”