Effects of hydro-ethanolic extract of leaves of Maesa lanceolata (Mursinaceae) on acetic acid-induced ulcerative colitis in rats

Tagne, Michel Archange Fokam; Tchoffo, Anatole; Noubissi, Paul Aimé; Mazo, Aimée Gisolène; Kom, Blaise; Mukam, Joseph Ngakou; Dongmo, Sélestin Sokeng; Kamgang, René

doi:10.1007/s10787-021-00825-8

Cited by 10 publications

(15 citation statements)

References 39 publications

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“…In this model, the reactive oxygen species, vasoactive amines and eicosanoids are involved in the destruction of the colon structure and the mucous barrier by chemical stimulation, increased vessel permeability, increased inflammatory mediators, and promotion of fibrin hydrolysis (Thippeswamy et al 2011). Bloody and mucous diarrhea, weight loss, relative and linear colon weight, and inflamed colon ulcerations are considered reliable and sensitive indicators of the severity of ulcerative colitis (Fokam Tagne et al 2021b;Fokam Tagne et al 2021a). In the present study, treatment of acetic acid-induced colitis in rats with hydroethanolic extract of Bixa orellana significantly reduced the frequency of diarrhea, relative and linear colon weight, number of gross lesions, and limited body weight loss compared to colitis control, indicating its effectiveness against ulcerative colitis.…”

Section: Discussionmentioning

confidence: 99%

“…All animals were then anesthetized with ether and each animal received rectally 1 mL of acetic acid (5%, v/v) solution except for the normal control group which received 1 mL of distilled water instead. After administration, the rats were kept in an upright position for 30 seconds to limit reflux of the acetic acid solution or distilled water (Fokam Tagne et al 2021a;Fokam Tagne et al 2021b). The animals were observed for forty eight hours for the establishment of colitis.…”

Section: Induction Of Colitis and Treatment Of Animalsmentioning

confidence: 99%

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Assessment of Pharmacological Properties of Hydroethanolic Extract of Bixa orellana (Bixaceae) Leaves on Acetic Acid-induced Colitis in Rat

Tagne¹,

Kom²,

Fondjo³

et al. 2021

Preprint

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Ulcerative colitis is one of the inflammatory bowel diseases that is increasing in incidence worldwide. The objective of this work was to evaluate the activities of the hydroethanolic extract of the leaves of Bixa orellana on colitis in rats. Thirty-six rats were anesthetized with ether after 18 hours of fasting and ulcerative colitis was induced by intrarectal administration of 1 mL of acetic acid (5%) in all animals except the normal control group which received instead distilled water (1 mL). 48 hours after induction, the normal control and the negative control received distilled water (10 mL/kg), the positive control received loperamide (5 mg/kg) and three test groups received hydroethanolic extract Bixa orellana leaves at 100, 200 and 400 mg/kg per day for seven days. Administration of the extract significantly (P <0.01) reduced the number of diarrheal stools, nitric oxide and malonedialdheide levels, anemia and the number of colon lesions. The extract significantly (P <0.01) improved body weight loss as well as antioxidant parameters (superoxide dismutase, catalase, gluthation). These results would justify the use of Bixa orellana in the treatment of inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

Section: Induction Of Colitis and Treatment Of Animalsmentioning

confidence: 99%

Assessment of Pharmacological Properties of Hydroethanolic Extract of Bixa orellana (Bixaceae) Leaves on Acetic Acid-induced Colitis in Rat

Tagne¹,

Kom²,

Fondjo³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

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“… Hematological diseases: lymphoma, leukemia, autoimmune hemolytic anemia and idiopathic thrombocytopenia (Malpica and Moll 2020 ). Rheumatological disorders: rheumatoid arthritis, systemic lupus erythematosus, polymyositis, vasculitis and polymyalgia rheumatica (Fokam et al 2021 ). Ophthalmological disorders: optic neuritis, uveitis, and keratoconjunctivitis (Scherer et al 2014 ).…”

Section: Pharmacology Of Corticosteroidsmentioning

confidence: 99%

“…Rheumatological disorders: rheumatoid arthritis, systemic lupus erythematosus, polymyositis, vasculitis and polymyalgia rheumatica (Fokam et al 2021 ).…”

Section: Pharmacology Of Corticosteroidsmentioning

confidence: 99%

COVID-19 and corticosteroids: a narrative review

et al. 2022

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It has been reported that corticosteroid therapy was effective in the management of severe acute respiratory syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), and recently in coronavirus disease 2019 (COVID-19). Corticosteroids are potent anti-inflammatory drugs that mitigate the risk of acute respiratory distress syndrome (ARDS) in COVID-19 and other viral pneumonia, despite a reduction of viral clearance; corticosteroids inhibit the development of cytokine storm and multi-organ damage. The risk–benefit ratio should be assessed for critical COVID-19 patients. In conclusion, corticosteroid therapy is an effective way in the management of COVID-19, it reduces the risk of complications primarily acute lung injury and the development of ARDS. Besides, corticosteroid therapy mainly dexamethasone and methylprednisolone are effective in reducing the severity of COVID-19 and associated comorbidities such as chronic obstructive pulmonary diseases (COPD), rheumatoid arthritis, and inflammatory bowel disease (IBD).

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“…The acetone extract of M. lanceolata leaves showed a good safety profile, excellent in vitro antibacterial activity, and relatively low antioxidant activity [ 35 , 36 ]. An investigational work has shown that the hydroethanolic leaf extract of M. lanceolata alleviates the manifestations of chemical-induced ulcerative colitis in laboratory rats [ 37 ]. Research done in East Africa revealed that the chloroform extract of M. lanceolata leaves showed in vitro antiplasmodial activity [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Suppressive, Curative, and Prophylactic Effects of Maesa lanceolata Forssk. against Rodent Malaria Parasite Plasmodium berghei

Tekalign

Tadege

Fisseha

et al. 2022

BioMed Research International

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The artemisinin partial resistance is believed to be spread to artemisinin-based combination therapy partner drugs. As a result, new antiplasmodial compounds are required to treat resistant malaria infections. In the invention of antimalarial substances, claimed medical plants are precious resources. So, the current study was designed to assess the antiplasmodial effects of Maesa lanceolata in mice. In this study, preliminary phytoconstituent and in vivo acute oral toxicity tests were done. Early infection, established infection, and residual infection tests were employed to determine the antimalarial effects of the test drugs. Three doses (200, 400, and 600 mg/kg) of the extracts were provided orally to the test mice. Analysis of variance (one-way) followed by post hoc Tukey’s test was used to analyze the difference between and within groups. Terpenoids, tannins, saponins, flavonoids, and alkaloids were detected in the phytochemical constituent analysis. Both 80% methanolic crude extract and solvent fractions had no toxic result at the 2000 mg/kg dose. All test drug doses suppressed parasite levels in a significant manner at all tests. The activity of chloroform fraction (maximum percentage suppression, 81.28%) overwhelms the crude extract activity. The curative effects of 80% methanolic crude extract, with a maximum of 80.22% parasitemia suppression, were greater than its suppressive and prophylactic effects. The 400 mg/kg dose of chloroform fraction resulted in a maximum survival period (18 days) than other doses of tested materials. The results of this investigation provide support for the activity of M. lanceolata leaf extract against malaria.

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Effects of hydro-ethanolic extract of leaves of Maesa lanceolata (Mursinaceae) on acetic acid-induced ulcerative colitis in rats

Cited by 10 publications

References 39 publications

Assessment of Pharmacological Properties of Hydroethanolic Extract of Bixa orellana (Bixaceae) Leaves on Acetic Acid-induced Colitis in Rat

Assessment of Pharmacological Properties of Hydroethanolic Extract of Bixa orellana (Bixaceae) Leaves on Acetic Acid-induced Colitis in Rat

COVID-19 and corticosteroids: a narrative review

Suppressive, Curative, and Prophylactic Effects of Maesa lanceolata Forssk. against Rodent Malaria Parasite Plasmodium berghei

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