Effects of Hydralazine and High Molecular Weight Dextran upon the Circulatory Responses to Severe Thermal Burns

Pathophysiology of burns

“…However, there are also sustained increases in catecholamine secretion and elevated systemic vascular resistance for up to five days after burn injury [50,65]. Michie et al measured CO and SVR in anesthetized dogs resuscitated after burn injury [66]. They found that CO fell shortly after injury and then returned normal; however, reduced CO did not parallel the blood volume deficit.…”

“…Hilton et al performed experiments in anesthetized dogs in which infusion of various peripheral vasodilators improved CO after burn injury [66,83]. They demonstrated a reduction in the peripheral vascular resistance and augmented CO after verapamil, but the myocardial force of contraction remained depressed.…”