Effects of human interleukin 3, macrophage and granulocyte-macrophage colony-stimulating factor on monocyte function following autologous bone marrow transplantation

Fabian, Ina; Shapira, Etya; Gadish, M.; Kletter, Yehudith; Nagler, Arnon; Flidel, Orna; Slavin, Shimon

doi:10.1016/0145-2126(92)90021-x

Cited by 16 publications

(5 citation statements)

References 27 publications

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“…The reasons for the maturation of monocytes in asthma are unclear, but may be related to chemotactic factors present in the peripheral blood of asthmatic patients and demonstrated for eosinophils and neutrophils [2,4]. Alternatively, cytokines present in the serum of asthmatics may have increased the oxidative burst of the cells [25][26][27]. The maturation of monocytes in asthma may be of importance for their increased recruitment into the airways [28,29].…”

Section: Discussionmentioning

confidence: 99%

Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages

Rivier

Pène

Rabesandratana

et al. 1995

Clinical and Experimental Immunology

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SUMMARY Airway macrophages are activated in asthmatic subjects. Peripheral blood monocytes from these subjects present some functional features of activation, but their membrane markers are not known. Recently a new subtype of blood monocytes, CD14+/CD16+, has been identified which possesses the characteristics of tissue macrophages. A study was carried out on nine normal subjects and 11 untreated asthmatics having variable severities of the disease to examine the phenotypic characteristics of monocytes. CD14, CD16, HLA‐DR, CD11a, CD11b, CD44 and CD54 were studied using double fluorescence flow cytometry since these antigens have been defined in the CD14+/CD16+ monocytes. The functional activation of monocytes was examined using the release of superoxide anion. The co‐expression of CD14 and CD16 by monocytes in terms of percentage and mean fluorescence intensity was significantly higher in asthmatics (P < 0·002 and P < 0·0001, respectively, Mann‐Whitney U‐test). There was no difference for the other membrane markers between asthmatics and normal subjects. Superoxide anion release was significantly increased in asthmatic subjects (P < 0·01). This study shows that most blood monocytes of asthmatics are CD14+/CD16+ and are likely to present features of tissue macrophages.

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Section: Discussionmentioning

confidence: 99%

Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages

Rivier

Pène

Rabesandratana

et al. 1995

Clinical and Experimental Immunology

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“…Superoxide anion (OF) production by granulocytes and monocytes was determined by measuring superoxide dismutase inhibitable reduction of ferricytochrome C [6,7,14,17].…”

Section: Killing Of Candidamentioning

confidence: 99%

A kindred with Griscelli disease: Spectrum of neurological involvement

et al. 1993

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We report four members of a highly consanguineous family with silver-grey pigmentation of hair, two of whom had skin histology compatible with Griscelli disease. Unlike previously reported patients, they did not suffer from recurrent infections. In addition, there was a spectrum of neurological involvement varying from mild cognitive delay with a convulsive disorder in one patient, to a fatal degenerative course in three others. One patient developed a prolonged febrile illness with histological evidence of florid lymphoid hyperplasia.

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“…Repopulation of the myelomonocytic GM-CFU occurs in the presence of IL-3 or granulocyte-macrophage colony stimulating factor (GM-CSF) [37]. Commitment toward the macrophage lineage requires the presence of macrophage colony stimulating factor (M-CSF), along with IL-3 or GM-CSF [44,45]. The committed promonocytic cells mature into smaller monocytic cells that can enter the blood.…”

Section: Cells Of the Monocyte-macrophage Lineagementioning

confidence: 99%

Myelomonocytic Cell Lines in Modeling HIV-1 Infection of the Bone Marrow

Nonnemacher¹,

Quiterio²,

Allen³

et al. 2017

Biology of Myelomonocytic Cells

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Human immunodeficiency virus type 1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS), primarily infects T cells and cells of the monocyte-macrophage lineage. This is due to the presence of the cell surface receptor CD4 and the coreceptors, CXCR4, and CCR5. While the T-cell has classically been the cell type associated with HIV-1 disease progression, cells of the monocyte-macrophage lineage have also been shown to play a major role in this viral pathologic process. Classically, this has involved monocytic cells in the peripheral blood and tissue macrophages, however, over the course of HIV disease, the promyelomonocytic cells of the bone marrow (BM) have also been shown to play a role in pathogenesis retroviral disease in that they play an integral role in the reseeding of the periphery and end-organ tissues. This has involved an initial infection of the bone marrow hematopoietic progenitor cells. Given this observation, over the years there have been a number of cell lines that have been developed and provided valuable insights into research questions surrounding HIV-1 infection of the monocyte-macrophage cell lineage. In this regard, we will examine the biological and immunological properties of these BM-derived cell lines with respect to their utility in exploring the pathogenesis of HIV-1 in humans.

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Effects of human interleukin 3, macrophage and granulocyte-macrophage colony-stimulating factor on monocyte function following autologous bone marrow transplantation

Cited by 16 publications

References 27 publications

Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages

Blood monocytes of untreated asthmatics exhibit some features of tissue macrophages

A kindred with Griscelli disease: Spectrum of neurological involvement

Myelomonocytic Cell Lines in Modeling HIV-1 Infection of the Bone Marrow

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