Effects of human growth hormone therapy on melanocytic naevi

Bourguignon, J P; Ernould, C; Arrese, Jorge E.; Franchimont, Claudine; Piérard, G.E.; Heinrichs, Claudine; Craen, M.; Rochiccioli, P

doi:10.1016/0140-6736(93)90636-u

Cited by 92 publications

(49 citation statements)

References 6 publications

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“…In another series no increase was found in the number of large nevi [4]and, as observed in the general population, the number of nevi increased with age and was increased in individuals with fair skin. Histologic studies have reported no increase in dysplastic features [10, 11]. The presumption therefore would be that whatever genetic factor(s) are operative they simply cause an increase in the number of typical nevi.…”

Section: Discussionmentioning

confidence: 99%

Nevi and Melanoma: Lessons from Turner’s Syndrome

Gibbs

Brady²,

González³

et al. 2001

Dermatology

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Females with Turner’s syndrome (TS) have a markedly increased number of cutaneous nevi. While this is a well-recognized risk factor for cutaneous melanoma (CM), the incidence of this tumor in TS and the implications for our understanding of nevi and melanoma have not previously been considered. Here we report a case of an anorectal melanoma in a woman with TS and a review of the literature. Overall, there appears to be a lower than expected incidence of CM. Possible explanations are discussed and in particular the possible relationship between sex hormones and melanoma development as these girls fail to undergo normal pubertal development. Further study of this syndrome may provide important insights into the genetic factors involved in normal melanocyte and nevus development, the potential influence of sex hormones on melanoma development and the relationship between the presence of nevi and the risk of developing CM.

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Section: Discussionmentioning

confidence: 99%

Nevi and Melanoma: Lessons from Turner’s Syndrome

Gibbs

Brady²,

González³

et al. 2001

Dermatology

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“…Therapy with GH may trigger melanocyte growth, but it has been shown neither to increase the number of nevi nor to trigger malignant transformation (393, 408,409). No clear relationship has been found between GH therapy and other skin lesions (399).…”

Section: Dermatologymentioning

confidence: 99%

Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting

Gravholt¹,

Andersen

Conway

et al. 2017

European Journal of Endocrinology

876

1,259

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Turner syndrome affects 25-50 per 100,000 females and can involve multiple organs through all stages of life, necessitating multidisciplinary approach to care. Previous guidelines have highlighted this, but numerous important advances have been noted recently. These advances cover all specialty fields involved in the care of girls and women with TS. This paper is based on an international effort that started with exploratory meetings in 2014 in both Europe and the USA, and culminated with a Consensus Meeting held in Cincinnati, Ohio, USA in July 2016. Prior to this meeting, five groups each addressed important areas in TS care: 1) diagnostic and genetic issues, 2) growth and development during childhood and adolescence, 3) congenital and acquired cardiovascular disease, 4) transition and adult care, and 5) other comorbidities and neurocognitive issues. These groups produced proposals for the present guidelines. Additionally, four pertinent questions were submitted for formal GRADE (Grading of Recommendations, Assessment, Development and Evaluation) evaluation with a separate systematic review of the literature. These four questions related to the efficacy and most optimal treatment of short stature, infertility, hypertension, and hormonal replacement therapy. The guidelines project was initiated by the European Society of Endocrinology and the Pediatric Endocrine Society, in collaboration with the European Society for Paediatric Endocrinology, the Endocrine Society, the European Society of Human Reproduction and Embryology, the American Heart Association, the Society for Endocrinology, and the European Society of Cardiology. The guideline has been formally endorsed by the European Society of Endocrinology, the Pediatric Endocrine Society, the European Society for Paediatric Endocrinology, the European Society of Human Reproduction and Embryology and Summary of recommendationsThe recommendations (R) are worded as recommend (strong recommendation) and suggest (weak recommendation). We formally graded only the evidence underlying recommendations for therapeutic choices. The quality of evidence behind the recommendations is classified as very low (⨁◯◯◯), low (⨁⨁◯◯), moderate (⨁⨁⨁◯) and strong (⨁⨁⨁⨁). See further section 'Summary of methods used for guideline development'. Diagnosis and geneticsR 1.1. We recommend considering a diagnosis of TS in phenotypic females with a karyotype containing one X chromosome and complete or partial absence of the second sex chromosome, associated with one or more typical clinical manifestations of TS (⨁⨁⨁⨁). R 1.2. We recommend against considering a diagnosis of TS in females with one X chromosome and a deletion distal to Xq24 on the other X chromosome, and in women over the age of 50 years with less than 5% 45,X mosaicism (⨁⨁◯◯). R 1.3. We suggest that the new general surveillance management guideline applies to TS patients with any karyotype (⨁⨁◯◯). R 1.4. We recommend to consider testing for Turner syndrome (TS) in a female with typical signs (Table 2) (⨁⨁⨁⨁). R 1.5. We ...

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“…Thus, not only systemic but also paracrine and/or autocrine cutaneous activity of the GH-IGF system contributes to skin homeostasis [11][12][13][14][15]. GH supplementation induces skin changes [16][17][18][19][20][21], a part of which may correspond to some corrective effects on ageing skin [22].…”

Section: Ageing Of the Endocrine Systemmentioning

confidence: 99%

Skin in maturity: the endocrine and neuroendocrine pathways

Quatresooz

Piérard‐Franchimont

Kharfi

et al. 2007

Intern J of Cosmetic Sci

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SynopsisIrrespective of age, most of the skin components are under the physiological control of endocrine and neuroendocrine factors. There is evidence that skin ageing appears complex showing much interindividual variability. Conceptually, ageing is a single biological process that is influenced and modulated by a series of various internal and exogenous factors. Among them, hormones and neuroendocrine signals play key roles in several ways. Ageing of most endocrine glands will in turn alter the skin biology. In addition, the age-related reduction in the intrinsic neuroendocrine activity of the skin will also alter the ageing rate of this organ. At last, various endocrinopathies will boost or conversely decrease the severity of the signs of cutaneous ageing. Ré suméIndépendamment de l'âge, la plupart des composants de la peau sont sous le contrôle physiologique de facteurs endocriniens et neuroendocriniens. Il semble évident, que le vieillissement cutané apparaît complexe, révélant une grande variabilité interindividuelle. Conceptuellement, le vieillissement est un processus biologique unique qui est influencé et modulé par une ensemble de divers facteurs internes et externes. Parmi eux, les hormones et les signaux neuroendocriniens jouent des rôles clés de diverses manières. D'une part, le vieillissement de la plupart des glandes endocrines va, par voie de conséquence, altérer la biologie cutanée. D'autre part, la réduction liée à l'âge de l'activité neuroendocrinienne intrinsèque de la peau altère aussi la progression du vieillissement de cet organe. Enfin, diverses endocrinopathies peuvent accélérer ou, en revanche, réduire la sévérité des signes du vieillissement cutané.

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Effects of human growth hormone therapy on melanocytic naevi

Cited by 92 publications

References 6 publications

Nevi and Melanoma: Lessons from Turner’s Syndrome

Nevi and Melanoma: Lessons from Turner’s Syndrome

Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting

Skin in maturity: the endocrine and neuroendocrine pathways

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