Abstract:Growth hormone (GH) replacement therapy has been proved to show beneficial effects on abnormalities of lipid metabolism in adult growth hormone deficiency (GHD) patients. To support this clinical evidence, we studied the effects of recombinant human growth hormone (rhGH) in combination with L-thyroxine (T4) and corticosterone (CS) on lipid metabolism in hypophysectomized (HPX) mature rats. Hypophysectomy resulted in marked increases of body fat and serum low density lipoprotein (LDL)-cholesterol similarly to t… Show more
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