Effects of human growth hormone on immune functions: In vitro studies on cells of normal and growth hormone-deficient children

Rapaport, Robert; Oleske, James M.; Ahdieh, Harry; Skuza, Kathryn A.; Holland, Bart; Passannante, Marian R.; Denny, Thomas N.

doi:10.1016/0024-3205(87)90545-5

Cited by 45 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In hGH-deficient children, several studies did not find any difference in the percentage of lymphocytes Thelper and T-suppressor/cytotoxicity lymphocytes lymphocytes and NK cells in comparison to normal controls (101)(102)(103)(104)(105). During long-term hGH (101-103) or short-term GHRH (105) substitution therapy, no changes in the number of lymphocytes, T-helper and T-suppressor/cytotoxicity lymphocytes and NK cells were seen.…”

mentioning

confidence: 87%

“…In hGH-deficient children, several studies did not find any significant difference in basal and PHA-, Con A-or PWM-stimulated lymphocyte proliferation in compar¬ ison to controls (101-103), but during hGH replace¬ ment therapy an increase of basal or PHA-stimulated proliferation was reported (101,102). Furthermore, the proliferation of immortalized human cells of Larontype dwarfs could be stimulated by IGF-I but not by GH (69).…”

mentioning

confidence: 91%

See 1 more Smart Citation

Effects of growth hormone and insulin-like growth factor I on the immune system

Auernhammer

Strasburger²

1995

European Journal of Endocrinology

139

View full text Add to dashboard Cite

Growth hormone-releasing hormone (GHRH), growth hormone (GH), prolactin (PRL) and insulin-like growth factor I (IGF-I) are synthesized and secreted by various immunocompetent cells. In addition, GHRH, GH, PRL and IGF-I receptors are expressed on immune cells. Growth hormone, PRL and IGF-I stimulate the proliferation of immunocompetent cells and modulate humoral and cellular immune functions, i.e. immunoglobuline secretion of B cells, thymulin secretion of thymic epithelial cells, natural killer cell activity, phagocytosis, oxidative burst and killing capacity of neutrophils and macrophages. No clinically significant cellular or humoral immunodeficiency has been found in GH-deficient patients. However, several immunological parameters and functions are altered in GH-deficient patients when compared to normal controls. The data available to date indicate that endocrine and pleiotropic para- and autocrine mechanisms of action are involved in a neuropeptide immune network, including GH, PRL and IGF-I as modulators of immune function.

show abstract

mentioning

confidence: 87%

mentioning

confidence: 91%

Effects of growth hormone and insulin-like growth factor I on the immune system

Auernhammer

Strasburger²

1995

European Journal of Endocrinology

139

View full text Add to dashboard Cite

show abstract

“…1977;Berczi and Nagy 1987;Tapson and Berman 1987;Gruler et al 1988;Kelley 1988Kelley , 1989Baxter et al , 1991Blalock 1989; Guarcello et al 1989;Rothe and Falanga 1989;Green and Berman 1990;Sara and Hall 1990;Blalock 1990, 1991;Gelato 1993 responses that are T cell-dependent (Fabris et al 1971a;van Buul-Offers et al 1981;Roth et al 1984;reviewed by Berczi 1986;Kelley 1989). Observed effects of GH deficiency on the human immune system have been less consistent (Crist et al 1987;Rapaport et al 1987;Bozzola et al 1988bBozzola et al 1989Kiess et al 1988;Spadoni et al 1989 (Roth et al 1984) were treated with GH. Similarly, the deficient cellular responses of lymphocytes from hypophysectomized rodents were reversed to normal levels by GH administration (Berczi et al 1985).…”

Section: Effects Of Growth Hormone On Body Conditionmentioning

confidence: 99%

A review of bovine growth hormone

Burton¹,

McBride²,

Block³

et al. 1994

Can. J. Anim. Sci.

132

View full text Add to dashboard Cite

. 74: 16'7-201. Unprecedented numbers of technical papers, abstracts, and short communications have been published in the past decade regarding the effects of exogenous bovine growth hormone on milk production, health, and reproductive efficiency of treated dairy cows. In well-managed dairy herds, exogenous growth hormone increases milk production without altering normal variability in milk composition. This has held true regardless of dairy breed tested, geographical location studied, or feeding management system used. Also consistent across studies is the rapidity of the galactopoietic effect of administered bovine growth hormone, which arises from altered partitioning and use of post-absorptive nutrients and increased synthetic capacity of the mammary gland. Growth hormone and its associated peptide, insulin-like growth factor-I, are now known to provide chronic lipolytic, diabetogenic, and gluconeogenic signals to target tissues culminating in increased mammary gland availability of glucose and nonesterified fatty acids. Together with yet ill-defined effects on mammary secretory tissue, this homeorhetic control of metabolism elicited by exogenous growth hormone is so efficient that treated cows are not more susceptible to metabolic disorders than untreated cows. However, some studies have reported an increased frequency of mastitis in groups of treated cows. This has been attributed mainly to increased milk volume in the mammary glands of treated cows and no convincing data are available that show decreased mammary gland immunity as a result of growth hormone treatments. On the contrary, an expanding body of evidence implicates growth hormone as a key neuroendocrine factor that is required for immunological competence. Trends of decreased reproductive efficiency in cows treated with growth hormone have also been reported, but available data imply that this is probably an indirect effect via prolonged negative energy balance in cows treated in early lactation rather than a direct negative effect on estrous cycling via altered reproductive hormone profiles. The objectives of the present review are to bring into focus and summarize pertinent biological discoveries regarding the treatment of dairy cows with recombinant bovine growth hormone, and to explore areas where additional growth hormone research is needed or warranted.Key words: Growth hormone, somatotropin, dairy cows, insulin-like growth factor-I Burton, J. L., McBride, B. W., Block, E., Glimm, D. et Kennelly,E. 1994. L'horrnone de croissance bovinemais au point bibliographique. Can. J. Anim. Sci. 74: . D'innombrables m6moires techniques, r6sum6s analytiques et communications brdves ont 6t6 publi6s dans la dernidre d6cennie au sujet des effets de I'hormone de croissance bovine exogdne sur la production laitidre, sur la sant6 et sur les fonctions de reproduction des vaches laitidres trait6es. Dans les 6levages laitiers bien conduits, la GH exogbne accroit la production de lait sans modifier la variabilit6 normale de sa composition, et cela inddpendamme...

show abstract

“…Exogenous GH can partly revert thymic involution and thymulin secretion in aged animals [100]. Furthermore, GH has immunoenhancing effects when administered to animals with hypopituitarism [101] and GH-deficient children [102]. These effects may be partly mediated by insulinlike growth factor 1, the liver synthesis of which is induced by GH.…”

Section: Mechanisms Of Immunoneuroendocrine Interactions and Their Momentioning

confidence: 99%

Psychoneuroimmunology and Aging

et al. 1998

View full text Add to dashboard Cite

Background: The senescence of the immune system is a complex phenomenon, characterized by impairment of several lymphocyte activities and generally considered a state of immune dysregulation. Aging is a condition associated with many social changes likely to induce psychological stress, which is often perceived as uncontrollable and can lead, in some cases, to clinically relevant depression. In the recent years a growing interest has been raised for the study of bidirectional interactions between the central nervous system and the immunological network (psychoneuroimmunology). Objective and Methods: We analyzed the possibility that chronic psychological distress and depression could worsen some immune functions in the aged. We postulate the neuroendocrine mechanisms of psychoimmune interaction, analyzing both the human and animal studies focused on aging. Results: The data from the literature reviewed suggest a significant impact of affective disorders on immune functions in the elderly subjects. This psychoimmune imbalance appears particularly important when the studies are carried out in otherwise healthy aged people. Conclusions: Here we reviewed the relationships between psychological stress and depression and immunological functions, with particular regard to those aspects pertinent to the aging process. The clinical relevance of these interactions remains to be elucidated, but the high frequency in the aged of autoimmune, infectious, and neoplastic diseases suggests to focus on the psychoneuroimmune interactions in the old age. We also propose some outlines for future studies concerning psychoneuroimmunology and aging.

show abstract

Effects of human growth hormone on immune functions: In vitro studies on cells of normal and growth hormone-deficient children

Cited by 45 publications

References 15 publications

Effects of growth hormone and insulin-like growth factor I on the immune system

Effects of growth hormone and insulin-like growth factor I on the immune system

A review of bovine growth hormone

Psychoneuroimmunology and Aging

Contact Info

Product

Resources

About