Effects of hot-water extract of <i>Paecilomyces hepiali</i> on hypertension parameters in Spontaneously Hypertensive Rats

Abstract

In this study, effects of hot water extract of Paecilomyces hepiali mycelia on hypertension parameters in spontaneously hypertensive rats (SHR) were investigated. The tested parameters included blood pressure, blood and urine biochemical composition, renin and angiotensin II levels in the blood. Prior to these tests, the extract was examined for toxicity. The fungus was cultivated in a solid medium composed of 40 g brown rice, 0.32 g glucose, 0.65 g sucrose, 2 g peptone and 65 ml corn steep liquor. No abnormality or harmful effects were observed in the toxicity test. Administration of a continuous-dose, once daily, to SHR for 27 weeks (from 13 weeks of age) decreased the systolic blood pressure (SBP) significantly. Levels of blood urea nitrogen, β-lipoprotein lipid peroxides and low density lipoprotein were significantly lower in the treated groups when compared to the control group. Urinary protein was significantly reduced in the middle and high dose groups. In comparison with the control group (0 mg/kg/10ml/day), significantly higher values were obtained for total cholesterol in groups that were given middle (170 mg/kg/10ml/day) and high (250 mg/kg/10ml/day) dosages. In all dosages (low, middle and high) the values for triglyceride were significantly higher than value found in the control group. In terms of angiotensin II levels, the value in the control group was markedly higher than values in the other groups. The results suggest that oral administration of hot water extract of P. hepiali mycelia has ability to control hypertension in rats.

Nutritional Requirements for Mycelial Growth of <i>Ophiocordyceps sinensis</i> on Agar Media

“…First cultivation method is to use the liquid-state cultivation and the other type of method is using the solid-state cultivation [16]. However, on the industrial level, cultivation production for the fruiting bodies has not been developed successfully in both cultivation methods and the production of the fermented mycelia is only limited to liquid cultivation [17] [18].…”

A Comparative Study on Chemical Composition and Pharmacological Effects of <i>Paecilomyces hepiali</i> and Wild <i>Ophiocordyceps sinensis</i>

“…Hirsutella sinensis is currently receiving general acceptance as the true anamorph of this mushroom [6]- [8]. Using spontaneously hypertensive rats, Chioza and Ohga [9] demonstrates that hot water extract of P. hepiali has antihypertensive effects.…”