Effects of hot melt extrusion processed nano-iron on growth
                    performance, blood composition, and iron bioavailability in weanling
                    pigs

Lee, JunHyung; Hosseindoust, Abdolreza; Kim, Min-Ju; Kim, KwangYeol; Choi, Youngin; Moturi, Joseph; Song, Chang‐Hyun; Lee, Song Yi; Cho, HyunJong; Chae, B. J.

doi:10.5187/jast.2019.61.4.216

Cited by 21 publications

(21 citation statements)

References 21 publications

(40 reference statements)

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“…Through the HME process, inorganic Cu (CuSO 4 ) was spread out, mixed with insolvent, and prepared for the present study. As known in the previous study, the HME technique already used in the drug industry via solid dispersion formulation even product as low level in water-soluble drugs [ 12 , 13 ]. Moreover, the soluplus as the main polymer matrix was applied in the HME process to optimize the solubility and bioavailability due to high amphiphilic characteristics [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens

et al. 2021

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This study was aimed to investigate the Cu bioavailability, growth response, digestibility of nutrients, and blood metabolites of broiler chicks fed CuSO 4 in nano or common forms. A total of 720 broiler chickens were distributed between eight treatments according to a completely randomized design. There were 8 treatments and 6 replicates in each treatment with 15 birds/replicate. The treatments were divided into common copper sulfate at the doses of 16 ppm, 40 ppm, 80 ppm, and 120 ppm (INO) and hot-melt extruded copper sulfate at the doses of 16 ppm, 40 ppm, 80 ppm, and 120 ppm (HME-Cu). The experiment was operated for 35 days in 2 phases (phase 1, d 0 to 14; and phase 2, d 15 to 35). No significant differences were shown in growth performance, feed intake, FCR, and nutrient digestibility among the treatments. The concentration of Cu in the serum was increased in the HME-Cu broilers compared with the INO broilers at phase 2. A linear increase was observed in the concentration of Cu in the liver in broilers fed INO diets, however, no significant differences were observed by the supplementation of HME-Cu levels. The linear increase was detected in the content of Cu in excreta in the INO and HME-Cu treatments by increasing the dietary Cu content. The HME-Cu treatments showed a lower Cu concentration in the excreta compared with the INO treatments. The higher bioavailability of Cu in HME form can decrease the recommended dose of Cu in broiler diets.

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Section: Introductionmentioning

confidence: 99%

Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens

et al. 2021

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“…The opposite of our results was obtained using nano-iron by hot melt extrusion (HME, 100 ppm Fe) as an alternative to ferrous sulphate. In many studies, the feed concentration of iron contained in nano particles ranges from 100 to 350 mg/kg feed [ 49 , 50 ]. It has been shown that the dietary nano-iron supplementation does not significantly improve the growth performance of weanling pigs [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…In many studies, the feed concentration of iron contained in nano particles ranges from 100 to 350 mg/kg feed [ 49 , 50 ]. It has been shown that the dietary nano-iron supplementation does not significantly improve the growth performance of weanling pigs [ 50 ]. Similarly, in our experiment, the growth of IONPs-supplemented piglets in the first days of life was relatively high but not significantly different from anemic animals, in which significant growth stunting was observed in comparison to FeDex-supplemented piglets.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Sucrosomial Iron and Iron Oxide Nanoparticles as Oral Supplements in Iron Deficiency Anemia in Piglets

Mazgaj

Lipiński

Szudzik

et al. 2021

IJMS

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Iron deficiency is the most common mammalian nutritional disorder. However, among mammalian species iron deficiency anemia (IDA), occurs regularly only in pigs. To cure IDA, piglets are routinely injected with high amounts of iron dextran (FeDex), which can lead to perturbations in iron homeostasis. Here, we evaluate the therapeutic efficacy of non-invasive supplementation with Sucrosomial iron (SI), a highly bioavailable iron supplement preventing IDA in humans and mice and various iron oxide nanoparticles (IONPs). Analysis of red blood cell indices and plasma iron parameters shows that not all iron preparations used in the study efficiently counteracted IDA comparable to FeDex-based supplementation. We found no signs of iron toxicity of any tested iron compounds, as evaluated based on the measurement of several toxicological markers that could indicate the occurrence of oxidative stress or inflammation. Neither SI nor IONPs increased hepcidin expression with alterations in ferroportin (FPN) protein level. Finally, the analysis of the piglet gut microbiota indicates the individual pattern of bacterial diversity across taxonomic levels, independent of the type of supplementation. In light of our results, SI but not IONPs used in the experiment emerges as a promising nutritional iron supplement, with a high potential to correct IDA in piglets.

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“…In addition, HME-Cu increased the Cu content of the liver compared to the control, and reduced the Cu content of the feces compared to the IN-Cu-supplemented diets. Our previous studies reported that HME improved the bioavailability and metabolic function of minerals, which in turn decreased the fecal mineral output in weanling pigs and broiler chickens [23,24,25,26,27,28]. Similarly, in chickens, diet supplementation with 20 mg/kg of inorganic and organic Cu increased the Cu content of their liver; and in weanling pigs, diet supplementation with 50 mg/kg of nano-Cu reduced their fecal Cu content compared to diet supplementation with 50 mg/kg of inorganic Cu [41,52].…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

“…Previous studies showed that HME-processed trace elements had the reduced particle size to nano by the addition of pharmaceutical excipients in order to increase the solubility and dispersion of trace elements [21,22]. Our previous studies have shown the improved bioavailability and metabolic function of HME-processed trace minerals in weanling pigs and broilers [23,24,25,26,27,28]. To evaluate the extent of the nano-process effect on minerals bioavailability in broiler chickens many studies are required, particularly that there are insufficient reports about these technologies at present.…”

Section: Introductionmentioning

confidence: 99%

Hot-melt extruded copper sulfate affects the growth performance, meat quality, and copper bioavailability of broiler chickens

et al. 2022

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Objective: This study was conducted to evaluate the effects of the supplementation of diets of broiler chickens with hot-melt extruded CuSO 4 (HME-Cu) on their growth performance, nutrient digestibility, gut microbiota, small intestinal morphology, meat quality, and copper (Cu) bioavailability.Methods: A total of 225 broilers (Ross 308), one-day old and initial weight 39.14 g, were weighed and distributed between 15 cages (15 birds per cage) in a completely randomized experimental design with 3 treatments (diets) and 5 replicates per treatment. Cages were allotted to three treatments including control (without supplemental Cu), IN-Cu (16 mg/kg of CuSO 4 ), and HME-Cu (16 mg/kg of HME processed CuSO 4 ). Results: The HME-Cu treatment tended to increase the overall body weight gain (BWG) (p<0.10). The apparent digestibility of Cu was increased by supplementation of HME-Cu at phase 2 (p<0.05). The Escherichia coli (E. coli) count in cecum tended to decrease with the supplementation with Cu (p<0.10). In addition, the HME-Cu treatment had a higher pH of breast meat than the control and IN-Cu treatments (p<0.05). Significant increases in the cooking loss (CL), water-holding capacity (WHC), and lightness in the breast were observed in the HME-Cu treatment compared to the control (p<0.05). The Cu content of excreta increased with the Cu supplementation (p<0.05). The concentration of excreta Cu in broilers was decreased in the HME-Cu compared to the IN-Cu in phase 2 (p<0.05). The Cu concentration in the liver was increased with the HME-Cu supplementation, compared with the control diets (p<0.05). Conclusion:This study showed that HME-Cu supplementation at the requirement level (16 mg/kg diets) in broiler diets did not affect the growth performance and the physiological function of Cu in broilers. However, supplementation of Cu in HME form improved the meat quality and the bioavailability of Cu.

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Effects of hot melt extrusion processed nano-iron on growth performance, blood composition, and iron bioavailability in weanling pigs

Cited by 21 publications

References 21 publications

Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens

Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens

Comparative Evaluation of Sucrosomial Iron and Iron Oxide Nanoparticles as Oral Supplements in Iron Deficiency Anemia in Piglets

Hot-melt extruded copper sulfate affects the growth performance, meat quality, and copper bioavailability of broiler chickens

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